Discovery, SAR, and X‑ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library
Deng, Hongfeng, Zhou, Jingye, Sundersingh, Flora S, Summerfield, Jennifer, Somers, Don, Messer, Jeffrey A, Satz, Alexander L, Ancellin, Nicolas, Arico-Muendel, Christopher C, (Sargent) Bedard, Katie L, Beljean, Arthur, Belyanskaya, Svetlana L, Bingham, Ryan, Smith, Sarah E, Boursier, Eric, Carter, Paul, Centrella, Paolo A, Clark, Matthew A, Chung, Chun-wa, Davie, Christopher P, Delorey, Jennifer L, Ding, Yun, Franklin, G. Joseph, Grady, LaShadric C, Herry, Kenny, Hobbs, Clare, Kollmann, Christopher S, Morgan, Barry A, (Pothier) Kaushansky, Laura J, Zhou, Quan
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
Get full text
Journal Article
Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)
Deng, Hongfeng, O’Keefe, Heather, Davie, Christopher P, Lind, Kenneth E, Acharya, Raksha A, Franklin, G. Joseph, Larkin, Jonathan, Matico, Rosalie, Neeb, Michael, Thompson, Monique M, Lohr, Thomas, Gross, Jeffrey W, Centrella, Paolo A, O’Donovan, Gary K, Bedard, Katie L. (Sargent), van Vloten, Kurt, Mataruse, Sibongile, Skinner, Steven R, Belyanskaya, Svetlana L, Carpenter, Tiffany Y, Shearer, Todd W, Clark, Matthew A, Cuozzo, John W, Arico-Muendel, Christopher C, Morgan, Barry A
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
Get full text
Journal Article
Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor
Wu, Zining, Graybill, Todd L, Zeng, Xin, Platchek, Michael, Zhang, Jean, Bodmer, Vera Q, Wisnoski, David D, Deng, Jianghe, Coppo, Frank T, Yao, Gang, Tamburino, Alex, Scavello, Genaro, Franklin, G. Joseph, Mataruse, Sibongile, Bedard, Katie L, Ding, Yun, Chai, Jing, Summerfield, Jennifer, Centrella, Paolo A, Messer, Jeffrey A, Pope, Andrew J, Israel, David I
Published in ACS combinatorial science (14.12.2015)
Published in ACS combinatorial science (14.12.2015)
Get full text
Journal Article
DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry
Xia, Bing, Franklin, G. Joseph, Lu, Xiaojie, Bedard, Katie L, Grady, LaShadric C, Summerfield, Jennifer D, Shi, Eric X, King, Bryan W, Lind, Kenneth E, Chiu, Cynthia, Watts, Eleanor, Bodmer, Vera, Bai, Xiaopeng, Marcaurelle, Lisa A
Published in ACS medicinal chemistry letters (08.07.2021)
Published in ACS medicinal chemistry letters (08.07.2021)
Get full text
Journal Article