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Published in Science (American Association for the Advancement of Science) (27.07.2007)
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Mouse and Human Granzyme B Have Distinct Tetrapeptide Specificities and Abilities to Recruit the Bid Pathway
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Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
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Singh, Sheo B, Ondeyka, John G, Herath, Kithsiri B, Zhang, Chaowei, Jayasuriya, Hiranthi, Zink, Deborah L, Parthasarathy, Gopalakrishnan, Becker, Joseph W, Wang, Jun, Soisson, Stephen M
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Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase
Asante-Appiah, Ernest, Patel, Sangita, Desponts, Caroline, Taylor, Jillian M., Lau, Cheuk, Dufresne, Claude, Therien, Michel, Friesen, Rick, Becker, Joseph W., Leblanc, Yves, Kennedy, Brian P., Scapin, Giovanna
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Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Colwell, Lawrence, Becker, Joseph W, Parthasarathy, Gopalakrishnan, Tang, Yui S, Basilio, Ángela, Cummings, Richard, Hermes, Jeffery D, Lee, Sang Ho, Dorso, Karen, Motyl, Mary, Soisson, Stephen M, Shoop, Wesley, Genilloud, Olga, Vicente, Francisca, Silver, Lynn L, Singh, Sheo B, Kodali, Srinivas, Jayasuriya, Hiranthi, Bartizal, Ken, Cully, Doris, Barrett, John, Allocco, John, Pelaez, Fernando, Wang, Jun, Young, Katherine, Painter, Ronald, Michael, Bruce, Hernandez, Lorraine, Felcetto, Thomas, Galgoci, Andrew, Gill, Charles, Tormo, José R, Schmatz, Dennis, Zhang, Chaowei, Ondeyka, John, Herath, Kithsiri, Ha, Sookhee
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Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
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Published in Nature structural biology (01.09.2003)
Published in Nature structural biology (01.09.2003)
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The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
Rotonda, J, Nicholson, D W, Fazil, K M, Gallant, M, Gareau, Y, Labelle, M, Peterson, E P, Rasper, D M, Ruel, R, Vaillancourt, J P, Thornberry, N A, Becker, J W
Published in Nature structural biology (01.07.1996)
Published in Nature structural biology (01.07.1996)
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Functional Characterization and Crystal Structure of the C215D Mutant of Protein-tyrosine Phosphatase-1B
Romsicki, Yolanda, Scapin, Giovanna, Beaulieu-Audy, Veronique, Patel, Sangita, Becker, Joseph W., Kennedy, Brian P., Asante-Appiah, Ernest
Published in The Journal of biological chemistry (01.08.2003)
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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities
Einstein, Monica, Akiyama, Taro E, Castriota, Gino A, Wang, Chuanlin F, McKeever, Brian, Mosley, Ralph T, Becker, Joseph W, Moller, David E, Meinke, Peter T, Wood, Harold B, Berger, Joel P
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Isolation, enzyme-bound structure and antibacterial activity of platencin from Streptomyces platensis
SINGH, Sheo B, ONDEYKA, John G, HERATH, Kithsiri B, CHAOWEI ZHANG, JAYASURIYA, Hiranthi, ZINK, Deborah L, PARTHASARATHY, Gopalakrishnan, BECKER, Joseph W, JUN WANG, SOISSON, Stephen M
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The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B
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Published in Biochemistry (Easton) (07.10.2003)
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Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis
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Published in Journal of medicinal chemistry (06.05.2004)
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Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
Shi, Guo Q, Dropinski, James F, McKeever, Brian M, Xu, Shihua, Becker, Joseph W, Berger, Joel P, MacNaul, Karen L, Elbrecht, Alex, Zhou, Gaochao, Doebber, Thomas W, Wang, Peiran, Chao, Yu-Sheng, Forrest, Mike, Heck, James V, Moller, David E, Jones, A. Brian
Published in Journal of medicinal chemistry (30.06.2005)
Published in Journal of medicinal chemistry (30.06.2005)
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Surface-entropy reduction approaches to manipulate crystal forms of β-ketoacyl acyl carrier protein synthase II from Streptococcus pneumoniae
Parthasarathy, Gopalakrishnan, Cummings, Richard, Becker, Joseph W., Soisson, Stephen M.
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2008)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2008)
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The Structure of PTP-1B in Complex with a Peptide Inhibitor Reveals an Alternative Binding Mode for Bisphosphonates
Asante-Appiah, Ernest, Patel, Sangita, Dufresne, Claude, Roy, Patrick, Wang, Qingping, Patel, Vira, Friesen, Richard W, Ramachandran, Chidambaram, Becker, Joseph W, Leblanc, Yves, Kennedy, Brian P, Scapin, Giovanna
Published in Biochemistry (Easton) (23.07.2002)
Published in Biochemistry (Easton) (23.07.2002)
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Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme
Becker, Joseph W., Marcy, Alice I., Rokosz, Laura L., Axel, Melinda G., Burbaum, Jonathan J., Fitzgerald, Paula M.D., Cameron, Patricia M., Esser, Craig K., Hagmann, William K., Hermes, Jeffrey D., Springer, James P.
Published in Protein science (01.10.1995)
Published in Protein science (01.10.1995)
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