Synthesis of Rhazinicine by a Metal-Catalyzed CH Bond Functionalization Strategy
Beck, Elizabeth M., Hatley, Richard, Gaunt, Matthew J.
Published in Angewandte Chemie (International ed.) (07.04.2008)
Published in Angewandte Chemie (International ed.) (07.04.2008)
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Journal Article
Mild Aerobic Oxidative Palladium (II) Catalyzed C−H Bond Functionalization: Regioselective and Switchable C−H Alkenylation and Annulation of Pyrroles
Beck, Elizabeth M, Grimster, Neil P, Hatley, Richard, Gaunt, Matthew J
Published in Journal of the American Chemical Society (01.03.2006)
Published in Journal of the American Chemical Society (01.03.2006)
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Journal Article
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
Zuhl, Andrea M, Nolan, Charles E, Brodney, Michael A, Niessen, Sherry, Atchison, Kevin, Houle, Christopher, Karanian, David A, Ambroise, Claude, Brulet, Jeffrey W, Beck, Elizabeth M, Doran, Shawn D, O'Neill, Brian T, Am Ende, Christopher W, Chang, Cheng, Geoghegan, Kieran F, West, Graham M, Judkins, Joshua C, Hou, Xinjun, Riddell, David R, Johnson, Douglas S
Published in Nature communications (11.10.2016)
Published in Nature communications (11.10.2016)
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Journal Article
Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase
Butler, Christopher R., Beck, Elizabeth M., Harris, Anthony, Huang, Zhen, McAllister, Laura A., am Ende, Christopher W., Fennell, Kimberly, Foley, Timothy L., Fonseca, Kari, Hawrylik, Steven J., Johnson, Douglas S., Knafels, John D., Mente, Scot, Noell, G. Stephen, Pandit, Jayvardhan, Phillips, Tracy B., Piro, Justin R., Rogers, Bruce N., Samad, Tarek A., Wang, Jane, Wan, Shuangyi, Brodney, Michael A.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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Journal Article
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging
Zhang, Lei, Chen, Laigao, Beck, Elizabeth M, Chappie, Thomas A, Coelho, Richard V, Doran, Shawn D, Fan, Kuo-Hsien, Helal, Christopher J, Humphrey, John M, Hughes, Zoe, Kuszpit, Kyle, Lachapelle, Erik A, Lazzaro, John T, Lee, Chewah, Mather, Robert J, Patel, Nandini C, Skaddan, Marc B, Sciabola, Simone, Verhoest, Patrick R, Young, Joseph M, Zasadny, Kenneth, Villalobos, Anabella
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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Journal Article
Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1
Beck, Elizabeth M, Parnell, Euan, Cowley, Angela, Porter, Alison, Gillespie, Jonathan, Robinson, John, Robinson, Lindsay, Pannifer, Andrew D, Hamon, Veronique, Jones, Philip, Morrison, Angus, McElroy, Stuart, Timmerman, Martin, Rutjes, Helma, Mahajan, Pravin, Wiejak, Jolanta, Luchowska-Stańska, Urszula, Morgan, David, Barker, Graeme, Rehmann, Holger, Yarwood, Stephen J
Published in Cells (Basel, Switzerland) (12.11.2019)
Published in Cells (Basel, Switzerland) (12.11.2019)
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Journal Article
Biased representation of disturbance rates in the roadside sampling frame in boreal forests: implications for monitoring design
Van Wilgenburg, Steven L., Beck, Elizabeth M., Obermayer, Brennan, Joyce, Timothy, Weddle, Brett
Published in Avian conservation and ecology (01.12.2015)
Published in Avian conservation and ecology (01.12.2015)
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Journal Article
Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand
Zhang, Lei, Villalobos, Anabella, Beck, Elizabeth M, Bocan, Thomas, Chappie, Thomas A, Chen, Laigao, Grimwood, Sarah, Heck, Steven D, Helal, Christopher J, Hou, Xinjun, Humphrey, John M, Lu, Jiemin, Skaddan, Marc B, McCarthy, Timothy J, Verhoest, Patrick R, Wager, Travis T, Zasadny, Kenneth
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Journal Article
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor
Butler, Christopher R., Popiolek, Michael, McAllister, Laura A., LaChapelle, Erik A., Kramer, Melissa, Beck, Elizabeth M., Mente, Scot, Brodney, Michael A., Brown, Matthew, Gilbert, Adam, Helal, Chris, Ogilvie, Kevin, Starr, Jeremy, Uccello, Daniel, Grimwood, Sarah, Edgerton, Jeremy, Garst-Orozco, Jonathan, Kozak, Rouba, Lotarski, Susan, Rossi, Amie, Smith, Deborah, O’Connor, Rebecca, Lazzaro, John, Steppan, Claire, Steyn, Stefanus J.
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
Brodney, Michael A, Beck, Elizabeth M, Butler, Christopher R, Barreiro, Gabriela, Johnson, Eric F, Riddell, David, Parris, Kevin, Nolan, Charles E, Fan, Ying, Atchison, Kevin, Gonzales, Cathleen, Robshaw, Ashley E, Doran, Shawn D, Bundesmann, Mark W, Buzon, Leanne, Dutra, Jason, Henegar, Kevin, LaChapelle, Erik, Hou, Xinjun, Rogers, Bruce N, Pandit, Jayvardhan, Lira, Ricardo, Martinez-Alsina, Luis, Mikochik, Peter, Murray, John C, Ogilvie, Kevin, Price, Loren, Sakya, Subas M, Yu, Aijia, Zhang, Yong, O’Neill, Brian T
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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Journal Article
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
Butler, Christopher R, Ogilvie, Kevin, Martinez-Alsina, Luis, Barreiro, Gabriela, Beck, Elizabeth M, Nolan, Charles E, Atchison, Kevin, Benvenuti, Eric, Buzon, Leanne, Doran, Shawn, Gonzales, Cathleen, Helal, Christopher J, Hou, Xinjun, Hsu, Mei-Hui, Johnson, Eric F, Lapham, Kimberly, Lanyon, Lorraine, Parris, Kevin, O’Neill, Brian T, Riddell, David, Robshaw, Ashley, Vajdos, Felix, Brodney, Michael A
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Journal Article
Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6
De Vita, Elena, Smits, Niels, Hurk, Helma, Beck, Elizabeth M., Hewitt, Joanne, Baillie, Gemma, Russell, Emily, Pannifer, Andrew, Hamon, Véronique, Morrison, Angus, McElroy, Stuart P., Jones, Philip, Ignatenko, Natalia A., Gunkel, Nikolas, Miller, Aubry K.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
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Journal Article
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
Butler, Christopher R, Brodney, Michael A, Beck, Elizabeth M, Barreiro, Gabriela, Nolan, Charles E, Pan, Feng, Vajdos, Felix, Parris, Kevin, Varghese, Alison H, Helal, Christopher J, Lira, Ricardo, Doran, Shawn D, Riddell, David R, Buzon, Leanne M, Dutra, Jason K, Martinez-Alsina, Luis A, Ogilvie, Kevin, Murray, John C, Young, Joseph M, Atchison, Kevin, Robshaw, Ashley, Gonzales, Cathleen, Wang, Jinlong, Zhang, Yong, O’Neill, Brian T
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Journal Article
Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain
Zhang, Lei, Chen, Laigao, Dutra, Jason K, Beck, Elizabeth M, Nag, Sangram, Takano, Akihiro, Amini, Nahid, Arakawa, Ryosuke, Brodney, Michael A, Buzon, Leanne M, Doran, Shawn D, Lanyon, Lorraine F, McCarthy, Timothy J, Bales, Kelly R, Nolan, Charles E, O’Neill, Brian T, Schildknegt, Klaas, Halldin, Christer, Villalobos, Anabella
Published in Journal of medicinal chemistry (26.04.2018)
Published in Journal of medicinal chemistry (26.04.2018)
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