Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea‐pig model
Yao, X, Anderson, D L, Ross, S A, Lang, D G, Desai, B Z, Cooper, D C, Wheelan, P, McIntyre, M S, Bergquist, M L, MacKenzie, K I, Becherer, J D, Hashim, M A
Published in British journal of pharmacology (01.08.2008)
Published in British journal of pharmacology (01.08.2008)
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Journal Article
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
Moss, Marcia L, Jin, S.-L. Catherine, Milla, Marcos E, Burkhart, William, Carter, H. Luke, Chen, Wen-Ji, Clay, William C, Didsbury, John R, Hassler, Daniel, Hoffman, Christine R, Kost, Thomas A, Lambert, Millard H, Leesnitzer, M. Anthony, McCauley, Philip, McGeehan, Gerard, Mitchell, Justin, Moyer, Mary, Pahel, Gregory, Rocque, Warren, Overton, Laurie K, Schoenen, Frank, Seaton, Theresa, Su, Jui-Lan, Warner, Janet, Willard, Derril, Becherer, J. David
Published in Nature (London) (20.02.1997)
Published in Nature (London) (20.02.1997)
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Involvement of the proteasome in the programmed cell death of NGF‐deprived sympathetic neurons
Sadoul, R., Fernandez, P. A., Quiquerez, A. L., Martinou, I., Maki, M., Schröter, M., Becherer, J. D., Irmler, M., Tschopp, J., Martinou, J. C.
Published in The EMBO journal (01.08.1996)
Published in The EMBO journal (01.08.1996)
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Journal Article
Granzyme A is an interleukin 1 beta-converting enzyme
Irmler, M, Hertig, S, MacDonald, H R, Sadoul, R, Becherer, J D, Proudfoot, A, Solari, R, Tschopp, J
Published in The Journal of experimental medicine (01.05.1995)
Published in The Journal of experimental medicine (01.05.1995)
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Journal Article
Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor
McGeehan, Gerard M, Becherer, J. David, Bast, Robert C, Boyer, Cinda M, Champion, Brian, Connolly, Kevin M, Conway, James G, Furdon, Paul, Karp, Stephen, Kidao, Sudha, McElroy, Andrew B, Nichols, James, Pryzwansky, Katherine M, Schoenen, Frank, Sekut, Les, Truesdale, Anne, Verghese, Margrith, Warner, Janet, Ways, Judy P
Published in Nature (London) (18.08.1994)
Published in Nature (London) (18.08.1994)
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Journal Article
Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE)
Rabinowitz, Michael H, Andrews, Robert C, Becherer, J. David, Bickett, D. Mark, Bubacz, Dulce G, Conway, James G, Cowan, David J, Gaul, Micheal, Glennon, Kimberly, Lambert, Millard H, Leesnitzer, M. Anthony, McDougald, Darryl L, Moss, Marcia L, Musso, David L, Rizzolio, Michele C
Published in Journal of medicinal chemistry (22.11.2001)
Published in Journal of medicinal chemistry (22.11.2001)
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Journal Article
Structural features and biochemical properties of TNF- α converting enzyme (TACE)
Moss, M.L., Jin, S.-L.C., Becherer, J.D., Bickett, D.M., Burkhart, W., Chen, W.-J., Hassler, D., Leesnitzer, M.T., McGeehan, G., Milla, M., Moyer, M., Rocque, W., Seaton, T., Schoenen, F., Warner, J., Willard, D.
Published in Journal of neuroimmunology (01.02.1997)
Published in Journal of neuroimmunology (01.02.1997)
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Journal Article
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
Ludwig, Andreas, Hundhausen, Christian, Lambert, Millard H, Broadway, Neil, Andrews, Robert C, Bickett, D Mark, Leesnitzer, M Anthony, Becherer, J David
Published in Combinatorial chemistry & high throughput screening (01.03.2005)
Published in Combinatorial chemistry & high throughput screening (01.03.2005)
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Journal Article
Evidence for a Critical Role of the Tumor Necrosis Factor α Convertase (TACE) in Ectodomain Shedding of the p75 Neurotrophin Receptor (p75NTR)
Weskamp, Gisela, Schlöndorff, Johannes, Lum, Lawrence, Becherer, J. David, Kim, Tae-Wan, Saftig, Paul, Hartmann, Dieter, Murphy, Gillian, Blobel, Carl P.
Published in The Journal of biological chemistry (06.02.2004)
Published in The Journal of biological chemistry (06.02.2004)
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Journal Article
Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival
Lum, Lawrence, Wong, Brian R., Josien, Régis, Becherer, J. David, Erdjument-Bromage, Hediye, Schlöndorff, Johannes, Tempst, Paul, Choi, Yongwon, Blobel, Carl P.
Published in The Journal of biological chemistry (07.05.1999)
Published in The Journal of biological chemistry (07.05.1999)
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Journal Article
Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity
Roghani, Monireh, Becherer, J. David, Moss, Marcia L., Atherton, Ruth E., Erdjument-Bromage, Hediye, Arribas, Joaquin, Blackburn, R. Kevin, Weskamp, Gisela, Tempst, Paul, Blobel, Carl P.
Published in The Journal of biological chemistry (05.02.1999)
Published in The Journal of biological chemistry (05.02.1999)
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Journal Article
Sequencing and characterization of the soybean leaf metalloproteinase: Structural and functional similarity to the matrix metalloproteinase family
McGeehan, G. (Glaxco Research Institute, Research Triangle Park, NC), Burkhart, W, Anderegg, R, Becherer, J.D, Gillikin, J.W, Graham, J.S
Published in Plant physiology (Bethesda) (01.07.1992)
Published in Plant physiology (Bethesda) (01.07.1992)
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Journal Article
Specific Sequence Elements Are Required for the Expression of Functional Tumor Necrosis Factor-α-converting Enzyme (TACE)
Milla, Marcos E., Leesnitzer, M. Anthony, Moss, Marcia L., Clay, William C., Carter, H. Luke, Miller, Ann B., Su, Jui-Lan, Lambert, Millard H., Willard, Derril H., Sheeley, Douglas M., Kost, Thomas A., Burkhart, William, Moyer, Mary, Blackburn, R. Kevin, Pahel, Gregory L., Mitchell, Justin L., Hoffman, Christine R., Becherer, J. David
Published in The Journal of biological chemistry (22.10.1999)
Published in The Journal of biological chemistry (22.10.1999)
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