Abstract C086: NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples
Blagg, Julian, Riou, Philippe, Hervieu, Alexia, Piumatti, Eleonora, Rospo, Giuseppe, Arunachalam, Sasi, Meier, Bettina, Weeks, Sam, Rodriguez, Maria, Parmar, Kalpesh, Patel, Pradip, Peall, Adam, Tongue, Paige, McLaren, Tess, Workman, Robert, Bago, Ruzica, Robjohns, Stuart, Beaumont, Rebecca, Briggs, Mike, Langley, Gareth, Nichols, Charles, Clark, David, Winship, Paul, Rousseau, Benoit, Baker, Matthew, Drysdale, Martin, Germano, Giovanni, Bardelli, Alberto
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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