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Ogawa, Mina, Ogawa, Shinichiro, Bear, Christine E, Ahmadi, Saumel, Chin, Stephanie, Li, Bin, Grompe, Markus, Keller, Gordon, Kamath, Binita M, Ghanekar, Anand
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Published in Nature biotechnology (01.08.2015)
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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (Ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner
Eckford, Paul D.W., Li, Canhui, Ramjeesingh, Mohabir, Bear, Christine E.
Published in The Journal of biological chemistry (26.10.2012)
Published in The Journal of biological chemistry (26.10.2012)
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ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel
Wu, Yu-Sheng, Jiang, Janet, Ahmadi, Saumel, Lew, Alexandria, Laselva, Onofrio, Xia, Sunny, Bartlett, Claire, Ip, Wan, Wellhauser, Leigh, Ouyang, Hong, Gonska, Tanja, Moraes, Theo J., Bear, Christine E.
Published in Molecular pharmacology (01.10.2019)
Published in Molecular pharmacology (01.10.2019)
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Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells
Wong, Amy P, Chin, Stephanie, Xia, Sunny, Garner, Jodi, Bear, Christine E, Rossant, Janet
Published in Nature protocols (01.03.2015)
Published in Nature protocols (01.03.2015)
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Activity of a novel antimicrobial peptide against Pseudomonas aeruginosa biofilms
Beaudoin, Trevor, Stone, Tracy A., Glibowicka, Miroslawa, Adams, Christina, Yau, Yvonne, Ahmadi, Saumel, Bear, Christine E., Grasemann, Hartmut, Waters, Valerie, Deber, Charles M.
Published in Scientific reports (03.10.2018)
Published in Scientific reports (03.10.2018)
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Generation of functional ciliated cholangiocytes from human pluripotent stem cells
Ogawa, Mina, Jiang, Jia-Xin, Xia, Sunny, Yang, Donghe, Ding, Avrilynn, Laselva, Onofrio, Hernandez, Marcela, Cui, Changyi, Higuchi, Yuichiro, Suemizu, Hiroshi, Dorrell, Craig, Grompe, Markus, Bear, Christine E., Ogawa, Shinichiro
Published in Nature communications (11.11.2021)
Published in Nature communications (11.11.2021)
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Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans
Shojaie, Sharareh, Ermini, Leonardo, Ackerley, Cameron, Wang, Jinxia, Chin, Stephanie, Yeganeh, Behzad, Bilodeau, Mélanie, Sambi, Manpreet, Rogers, Ian, Rossant, Janet, Bear, Christine E., Post, Martin
Published in Stem cell reports (10.03.2015)
Published in Stem cell reports (10.03.2015)
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Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and Morphogenesis
Rizwan, Muhammad, Ling, Christopher, Guo, Chengyu, Liu, Tracy, Jiang, Jia-Xin, Bear, Christine E, Ogawa, Shinichiro, Shoichet, Molly S
Published in Advanced healthcare materials (01.12.2022)
Published in Advanced healthcare materials (01.12.2022)
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Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity
Quach, Henry, Farrell, Spencer, Wu, Ming Jia Michael, Kanagarajah, Kayshani, Leung, Joseph Wai-Hin, Xu, Xiaoqiao, Kallurkar, Prajkta, Turinsky, Andrei L., Bear, Christine E., Ratjen, Felix, Kalish, Brian, Goyal, Sidhartha, Moraes, Theo J., Wong, Amy P.
Published in Nature communications (13.07.2024)
Published in Nature communications (13.07.2024)
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Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue
Molinski, Steven V, Ahmadi, Saumel, Ip, Wan, Ouyang, Hong, Villella, Adriana, Miller, John P, Lee, Po‐Shun, Kulleperuma, Kethika, Du, Kai, Di Paola, Michelle, Eckford, Paul DW, Laselva, Onofrio, Huan, Ling Jun, Wellhauser, Leigh, Li, Ellen, Ray, Peter N, Pomès, Régis, Moraes, Theo J, Gonska, Tanja, Ratjen, Felix, Bear, Christine E
Published in EMBO molecular medicine (01.09.2017)
Published in EMBO molecular medicine (01.09.2017)
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Photochemically Activated Notch Signaling Hydrogel Preferentially Differentiates Human Derived Hepatoblasts to Cholangiocytes
Rizwan, Muhammad, Fokina, Ana, Kivijärvi, Tove, Ogawa, Mina, Kufleitner, Markus, Laselva, Onofrio, Smith, Laura J., Bear, Christine E., Ogawa, Shinichiro, Keller, Gordon, Shoichet, Molly S.
Published in Advanced functional materials (01.01.2021)
Published in Advanced functional materials (01.01.2021)
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A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells
Cuevas-Ocaña, Sara, Yang, Jin Ye, Aushev, Magomet, Schlossmacher, George, Bear, Christine E, Hannan, Nicholas R F, Perkins, Neil D, Rossant, Janet, Wong, Amy P, Gray, Michael A
Published in International journal of molecular sciences (01.06.2023)
Published in International journal of molecular sciences (01.06.2023)
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Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity
Malik, Firhan A, Meissner, Anja, Semenkov, Illya, Molinski, Steven, Pasyk, Stan, Ahmadi, Saumel, Bui, Hai H, Bear, Christine E, Lidington, Darcy, Bolz, Steffen-Sebastian
Published in PloS one (16.06.2015)
Published in PloS one (16.06.2015)
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CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system
Lim, Sang Hyun, Snider, Jamie, Birimberg‐Schwartz, Liron, Ip, Wan, Serralha, Joana C, Botelho, Hugo M, Lopes‐Pacheco, Miquéias, Pinto, Madalena C, Moutaoufik, Mohamed Taha, Zilocchi, Mara, Laselva, Onofrio, Esmaeili, Mohsen, Kotlyar, Max, Lyakisheva, Anna, Tang, Priscilla, López Vázquez, Lucía, Akula, Indira, Aboualizadeh, Farzaneh, Wong, Victoria, Grozavu, Ingrid, Opacak‐Bernardi, Teuta, Yao, Zhong, Mendoza, Meg, Babu, Mohan, Jurisica, Igor, Gonska, Tanja, Bear, Christine E, Amaral, Margarida D, Stagljar, Igor
Published in Molecular systems biology (01.02.2022)
Published in Molecular systems biology (01.02.2022)
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Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells
Tanjala, Adrian Constantin, Jiang, Jia Xin, Eckford, Paul D W, Ramjeesingh, Mohabir, Li, Canhui, Huan, Ling Jun, Langeveld, Gabrielle, Townsend, Claire, Paone, Daniel V, Busch-Petersen, Jakob, Pekhletski, Roman, Tang, LiPing, Raju, Vamsee, Rowe, Steven M, Bear, Christine E
Published in Respiratory research (10.07.2024)
Published in Respiratory research (10.07.2024)
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Perspectives on the translation of in-vitro studies to precision medicine in Cystic Fibrosis
Dumas, Marie-Pier, Xia, Sunny, Bear, Christine E., Ratjen, Felix
Published in EBioMedicine (01.11.2021)
Published in EBioMedicine (01.11.2021)
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Anti-Infectives Restore ORKAMBI ® Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of P. aeruginosa
Laselva, Onofrio, Stone, Tracy A, Bear, Christine E, Deber, Charles M
Published in Biomolecules (Basel, Switzerland) (19.02.2020)
Published in Biomolecules (Basel, Switzerland) (19.02.2020)
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A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients
Jiang, Jia Xin, Wellhauser, Leigh, Laselva, Onofrio, Utkina, Irina, Bozoky, Zoltan, Gunawardena, Tarini, Ngan, Zoe, Xia, Sunny, Di Paola, Michelle, Eckford, Paul D.W., Ratjen, Felix, Moraes, Theo J., Parkinson, John, Wong, Amy P., Bear, Christine E.
Published in Stem cell reports (09.11.2021)
Published in Stem cell reports (09.11.2021)
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SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion
Ahmadi, Saumel, Xia, Sunny, Wu, Yu-Sheng, Di Paola, Michelle, Kissoon, Randolph, Luk, Catherine, Lin, Fan, Du, Kai, Rommens, Johanna, Bear, Christine E
Published in eLife (13.07.2018)
Published in eLife (13.07.2018)
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