Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched
Zhang, Yunxiao, Bulkley, David P., Xin, Yao, Roberts, Kelsey J., Asarnow, Daniel E., Sharma, Ashutosh, Myers, Benjamin R., Cho, Wonhwa, Cheng, Yifan, Beachy, Philip A.
Published in Cell (15.11.2018)
Published in Cell (15.11.2018)
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Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
Myers, Benjamin R., Neahring, Lila, Zhang, Yunxiao, Roberts, Kelsey J., Beachy, Philip A.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2017)
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Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types
Loh, Kyle M., Chen, Angela, Koh, Pang Wei, Deng, Tianda Z., Sinha, Rahul, Tsai, Jonathan M., Barkal, Amira A., Shen, Kimberle Y., Jain, Rajan, Morganti, Rachel M., Shyh-Chang, Ng, Fernhoff, Nathaniel B., George, Benson M., Wernig, Gerlinde, Salomon, Rachel E.A., Chen, Zhenghao, Vogel, Hannes, Epstein, Jonathan A., Kundaje, Anshul, Talbot, William S., Beachy, Philip A., Ang, Lay Teng, Weissman, Irving L.
Published in Cell (14.07.2016)
Published in Cell (14.07.2016)
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Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors
Shin, Kunyoo, Lim, Agnes, Zhao, Chen, Sahoo, Debashis, Pan, Ying, Spiekerkoetter, Edda, Liao, Joseph C., Beachy, Philip A.
Published in Cancer cell (13.10.2014)
Published in Cancer cell (13.10.2014)
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Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma
KIM, Daniel J, KIM, James, TANG, Jean Y, SPAUNHURST, Katrina, MONTOYA, Javier, KHODOSH, Rita, CHANDRA, Kalyani, FU, Teresa, GILLIAM, Anita, MOLGO, Monserrat, BEACHY, Philip A
Published in Journal of clinical oncology (10.03.2014)
Published in Journal of clinical oncology (10.03.2014)
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Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response
Myers, Benjamin R., Sever, Navdar, Chong, Yong Chun, Kim, James, Belani, Jitendra D., Rychnovsky, Scott, Bazan, J. Fernando, Beachy, Philip A.
Published in Developmental cell (26.08.2013)
Published in Developmental cell (26.08.2013)
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The Hedgehog Response Network: Sensors, Switches, and Routers
Lum, Lawrence, Beachy, Philip A.
Published in Science (American Association for the Advancement of Science) (18.06.2004)
Published in Science (American Association for the Advancement of Science) (18.06.2004)
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Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
Kim, Jynho, Lee, John J., Kim, James, Gardner, Dale, Beachy, Philip A.
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
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Stromal response to Hedgehog signaling restrains pancreatic cancer progression
Lee, John J, Perera, Rushika M, Wang, Huaijun, Wu, Dai-Chen, Liu, X Shawn, Han, Shiwei, Fitamant, Julien, Jones, Phillip D, Ghanta, Krishna S, Kawano, Sally, Nagle, Julia M, Deshpande, Vikram, Boucher, Yves, Kato, Tomoyo, Chen, James K, Willmann, Jürgen K, Bardeesy, Nabeel, Beachy, Philip A
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
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Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
Kim, James, Aftab, Blake T., Tang, Jean Y., Kim, Daniel, Lee, Alex H., Rezaee, Melika, Kim, Jynho, Chen, Baozhi, King, Emily M., Borodovsky, Alexandra, Riggins, Gregory J., Epstein, Ervin H., Beachy, Philip A., Rudin, Charles M.
Published in Cancer cell (14.01.2013)
Published in Cancer cell (14.01.2013)
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Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein
Strating, Jeroen R.P.M., van der Linden, Lonneke, Albulescu, Lucian, Bigay, Joëlle, Arita, Minetaro, Delang, Leen, Leyssen, Pieter, van der Schaar, Hilde M., Lanke, Kjerstin H.W., Thibaut, Hendrik Jan, Ulferts, Rachel, Drin, Guillaume, Schlinck, Nina, Wubbolts, Richard W., Sever, Navdar, Head, Sarah A., Liu, Jun O., Beachy, Philip A., De Matteis, Maria A., Shair, Matthew D., Olkkonen, Vesa M., Neyts, Johan, van Kuppeveld, Frank J.M.
Published in Cell reports (Cambridge) (03.02.2015)
Published in Cell reports (Cambridge) (03.02.2015)
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Identification of recurrent SMO and BRAF mutations in ameloblastomas
Sweeney, Robert T, McClary, Andrew C, Myers, Benjamin R, Biscocho, Jewison, Neahring, Lila, Kwei, Kevin A, Qu, Kunbin, Gong, Xue, Ng, Tony, Jones, Carol D, Varma, Sushama, Odegaard, Justin I, Sugiyama, Toshihiro, Koyota, Souichi, Rubin, Brian P, Troxell, Megan L, Pelham, Robert J, Zehnder, James L, Beachy, Philip A, Pollack, Jonathan R, West, Robert B
Published in Nature genetics (01.07.2014)
Published in Nature genetics (01.07.2014)
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Journal Article
Cilia-Associated Oxysterols Activate Smoothened
Raleigh, David R., Sever, Navdar, Choksi, Pervinder K., Sigg, Monika Abedin, Hines, Kelly M., Thompson, Bonne M., Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R., Krup, Alexis Leigh, Eberl, Markus, Byrne, Eamon F.X., Siebold, Christian, Wong, Sunny Y., Renslo, Adam R., Grabe, Michael, McDonald, Jeffrey G., Xu, Libin, Beachy, Philip A., Reiter, Jeremy F.
Published in Molecular cell (18.10.2018)
Published in Molecular cell (18.10.2018)
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Control of inflammation by stromal Hedgehog pathway activation restrains colitis
Lee, John J., Rothenberg, Michael E., Seeley, E. Scott, Zimdahl, Bryan, Kawano, Sally, Lu, Wan-Jin, Shin, Kunyoo, Sakata-Kato, Tomoyo, Chen, James K., Diehn, Maximilian, Clarke, Michael F., Beachy, Philip A.
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
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Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration
Lu, Wan-Jin, Mann, Randall K., Nguyen, Allison, Bi, Tingting, Silverstein, Max, Tang, Jean Y., Chen, Xiaoke, Beachy, Philip A.
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2018)
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