Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
Brinkmann, Volker, Billich, Andreas, Baumruker, Thomas, Heining, Peter, Schmouder, Robert, Francis, Gordon, Aradhye, Shreeram, Burtin, Pascale
Published in Nature reviews. Drug discovery (01.11.2010)
Published in Nature reviews. Drug discovery (01.11.2010)
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Journal Article
Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo
Urtz, Nicole, Gaertner, Florian, von Bruehl, Marie-Luise, Chandraratne, Sue, Rahimi, Faridun, Zhang, Lin, Orban, Mathias, Barocke, Verena, Beil, Johannes, Schubert, Irene, Lorenz, Michael, Legate, Kyle R, Huwiler, Andrea, Pfeilschifter, Josef M, Beerli, Christian, Ledieu, David, Persohn, Elke, Billich, Andreas, Baumruker, Thomas, Schnitzler, Michael Mederos y, Massberg, Steffen
Published in Circulation research (31.07.2015)
Published in Circulation research (31.07.2015)
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Journal Article
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
Zemann, Barbara, Kinzel, Bernd, Müller, Matthias, Reuschel, Roland, Mechtcheriakova, Diana, Urtz, Nicole, Bornancin, Frédéric, Baumruker, Thomas, Billich, Andreas
Published in Blood (15.02.2006)
Published in Blood (15.02.2006)
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Journal Article
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
Brinkmann, Volker, Davis, Michael D, Heise, Christopher E, Albert, Rainer, Cottens, Sylvain, Hof, Robert, Bruns, Christian, Prieschl, Eva, Baumruker, Thomas, Hiestand, Peter, Foster, Carolyn A, Zollinger, Markus, Lynch, Kevin R
Published in The Journal of biological chemistry (14.06.2002)
Published in The Journal of biological chemistry (14.06.2002)
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Journal Article
FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage
Foster, Carolyn A., Mechtcheriakova, Diana, Storch, Maria K., Balatoni, Balázs, Howard, Laurence M., Bornancin, Frédéric, Wlachos, Alexander, Sobanov, Jury, Kinnunen, Anu, Baumruker, Thomas
Published in Brain pathology (Zurich, Switzerland) (01.04.2009)
Published in Brain pathology (Zurich, Switzerland) (01.04.2009)
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Journal Article
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis
Billich, Andreas, Baumruker, Thomas, Beerli, Christian, Bigaud, Marc, Bruns, Christian, Calzascia, Thomas, Isken, Andrea, Kinzel, Bernd, Loetscher, Erika, Metzler, Barbara, Mueller, Matthias, Nuesslein-Hildesheim, Barbara, Kleylein-Sohn, Bernadette
Published in PloS one (27.03.2013)
Published in PloS one (27.03.2013)
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Journal Article
Targeting Ceramide Metabolism with a Potent and Specific Ceramide Kinase Inhibitor
Graf, Christine, Klumpp, Martin, Habig, Michael, Rovina, Philipp, Billich, Andreas, Baumruker, Thomas, Oberhauser, Berndt, Bornancin, Frédéric
Published in Molecular pharmacology (01.10.2008)
Published in Molecular pharmacology (01.10.2008)
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Journal Article
IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses
Olivera, Ana, Urtz, Nicole, Mizugishi, Kiyomi, Yamashita, Yumi, Gilfillan, Alasdair M., Furumoto, Yasuko, Gu, Haihua, Proia, Richard L., Baumruker, Thomas, Rivera, Juan
Published in The Journal of biological chemistry (03.02.2006)
Published in The Journal of biological chemistry (03.02.2006)
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Journal Article
Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses
Mechtcheriakova, Diana, Wlachos, Alexander, Sobanov, Jury, Kopp, Tamara, Reuschel, Roland, Bornancin, Frederic, Cai, Richard, Zemann, Barbara, Urtz, Nicole, Stingl, Georg, Zlabinger, Gerhard, Woisetschläger, Maximilian, Baumruker, Thomas, Billich, Andreas
Published in Cellular signalling (01.04.2007)
Published in Cellular signalling (01.04.2007)
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Journal Article
The role of sphingosine and ceramide kinases in inflammatory responses
Baumruker, Thomas, Bornancin, Frédéric, Billich, Andreas
Published in Immunology letters (31.01.2005)
Published in Immunology letters (31.01.2005)
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Journal Article
Characterization of a ceramide kinase-like protein
Bornancin, Frédéric, Mechtcheriakova, Diana, Stora, Samantha, Graf, Christine, Wlachos, Alexander, Dévay, Piroska, Urtz, Nicole, Baumruker, Thomas, Billich, Andreas
Published in Biochimica et biophysica acta (21.02.2005)
Published in Biochimica et biophysica acta (21.02.2005)
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Journal Article
Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcεRI Are Mediated by Its Interaction with Lyn Kinase
Urtz, Nicole, Olivera, Ana, Bofill-Cardona, Elisa, Csonga, Robert, Billich, Andreas, Mechtcheriakova, Diana, Bornancin, Frederic, Woisetschläger, Max, Rivera, Juan, Baumruker, Thomas
Published in Molecular and Cellular Biology (01.10.2004)
Published in Molecular and Cellular Biology (01.10.2004)
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Journal Article
A critical β6–β7 loop in the pleckstrin homology domain of ceramide kinase
Rovina, Philipp, Jaritz, Markus, Höfinger, Siegfried, Graf, Christine, Dévay, Piroska, Billich, Andreas, Baumruker, Thomas, Bornancin, Frédéric
Published in Biochemical journal (01.12.2006)
Published in Biochemical journal (01.12.2006)
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Journal Article
Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain
Carré, Adeline, Graf, Christine, Stora, Samantha, Mechtcheriakova, Diana, Csonga, Robert, Urtz, Nicole, Billich, Andreas, Baumruker, Thomas, Bornancin, Frédéric
Published in Biochemical and biophysical research communications (26.11.2004)
Published in Biochemical and biophysical research communications (26.11.2004)
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Journal Article
Effects of ceramide-1-phosphate on cultured cells: dependence on dodecane in the vehicle
Tauzin, Loïc, Graf, Christine, Sun, Mei, Rovina, Philipp, Bouveyron, Nicolas, Jaritz, Markus, Winiski, Anthony, Hartmann, Nicole, Staedtler, Frank, Billich, Andreas, Baumruker, Thomas, Zhang, Mei, Bornancin, Frédéric
Published in Journal of lipid research (2007)
Published in Journal of lipid research (2007)
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Journal Article
The Synthesis and Biological Characterization of a Ceramide Library
Chang, Young-Tae, Choi, Jaehwa, Ding, Sheng, Prieschl, Eva E, Baumruker, Thomas, Lee, Jae-Mok, Chung, Sung-Kee, Schultz, Peter G
Published in Journal of the American Chemical Society (06.03.2002)
Published in Journal of the American Chemical Society (06.03.2002)
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Journal Article
Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5 Gene Expression in Th2 Cells
Klein-Hessling, Stefan, Jha, Mithilesh Kumar, Santner-Nanan, Brigitte, Berberich-Siebelt, Friederike, Baumruker, Thomas, Schimpl, Anneliese, Serfling, Edgar
Published in The Journal of immunology (1950) (15.03.2003)
Published in The Journal of immunology (1950) (15.03.2003)
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Journal Article
Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells
Jung, In Duk, Lee, Jun Sik, Kim, Yong Joo, Jeong, Young-Il, Lee, Chang-Min, Baumruker, Thomas, Billlich, Andreas, Banno, Yoshiko, Lee, Min Goo, Ahn, Soon-Choel, Park, Won Sun, Han, Jin, Park, Yeong-Min
Published in International immunology (01.04.2007)
Published in International immunology (01.04.2007)
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