Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target
Krystof, Vladimír, Baumli, Sonja, Fürst, Robert
Published in Current pharmaceutical design (01.07.2012)
Published in Current pharmaceutical design (01.07.2012)
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Journal Article
A structural perspective of CTD function
Meinhart, Anton, Kamenski, Tomislav, Hoeppner, Sabine, Baumli, Sonja, Cramer, Patrick
Published in Genes & development (15.06.2005)
Published in Genes & development (15.06.2005)
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Journal Article
Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation
Zaborowska, Justyna, Baumli, Sonja, Laitem, Clelia, O'Reilly, Dawn, Thomas, Peter H, O'Hare, Peter, Murphy, Shona
Published in PloS one (18.09.2014)
Published in PloS one (18.09.2014)
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Journal Article
Structure and VP16 binding of the Mediator Med25 activator interaction domain
Sattler, Michael, Cramer, Patrick, Vojnic, Erika, Mourão, André, Seizl, Martin, Simon, Bernd, Wenzeck, Larissa, Larivière, Laurent, Baumli, Sonja, Baumgart, Karen, Meisterernst, Michael
Published in Nature structural & molecular biology (01.04.2011)
Published in Nature structural & molecular biology (01.04.2011)
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Journal Article
Functional Architecture of RNA Polymerase I
Kuhn, Claus-D., Geiger, Sebastian R., Baumli, Sonja, Gartmann, Marco, Gerber, Jochen, Jennebach, Stefan, Mielke, Thorsten, Tschochner, Herbert, Beckmann, Roland, Cramer, Patrick
Published in Cell (28.12.2007)
Published in Cell (28.12.2007)
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Journal Article
Preparation and topology of the Mediator middle module
Koschubs, Tobias, Lorenzen, Kristina, Baumli, Sonja, Sandström, Saana, Heck, Albert J.R, Cramer, Patrick
Published in Nucleic acids research (01.06.2010)
Published in Nucleic acids research (01.06.2010)
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Journal Article
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Baumli, Sonja, Lolli, Graziano, Lowe, Edward D, Troiani, Sonia, Rusconi, Luisa, Bullock, Alex N, Debreczeni, Judit É, Knapp, Stefan, Johnson, Louise N
Published in The EMBO journal (09.07.2008)
Published in The EMBO journal (09.07.2008)
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Journal Article
Substituted 4‑(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X‑ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities
Shao, Hao, Shi, Shenhua, Huang, Shiliang, Hole, Alison J, Abbas, Abdullahi Y, Baumli, Sonja, Liu, Xiangrui, Lam, Frankie, Foley, David W, Fischer, Peter M, Noble, Martin, Endicott, Jane A, Pepper, Chris, Wang, Shudong
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Journal Article
A Conserved Mediator Hinge Revealed in the Structure of the MED7·MED21 (Med7·Srb7) Heterodimer
Baumli, Sonja, Hoeppner, Sabine, Cramer, Patrick
Published in The Journal of biological chemistry (06.05.2005)
Published in The Journal of biological chemistry (06.05.2005)
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Journal Article
Comparative Structural and Functional Studies of 4‑(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity
Hole, Alison J, Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M, Wang, Shudong, Endicott, Jane A, Noble, Martin E
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Journal Article
Identification, structure, and functional requirement of the Mediator submodule Med7N/31
Koschubs, Tobias, Seizl, Martin, Larivière, Laurent, Kurth, Fabian, Baumli, Sonja, Martin, Dietmar E, Cramer, Patrick
Published in The EMBO journal (07.01.2009)
Published in The EMBO journal (07.01.2009)
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Journal Article
Herpes Simplex Virus 1
Zaborowska, Justyna, Baumli, Sonja, Laitem, Clelia, O'Reilly, Dawn, Thomas, Peter H, O'Hare, Peter, Murphy, Shona
Published in PloS one (18.09.2014)
Published in PloS one (18.09.2014)
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Journal Article
Herpes Simplex Virus 1 9 to Inhibit RNA Polymerase II Transcription Elongation
Zaborowska, Justyna, Baumli, Sonja, Laitem, Clelia, O'Reilly, Dawn, Thomas, Peter H, O'Hare, Peter, Murphy, Shona
Published in PloS one (18.09.2014)
Published in PloS one (18.09.2014)
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Journal Article
The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508
Baumli, Sonja, Hole, Alison J, Noble, Martin E. M, Endicott, Jane A
Published in ACS chemical biology (18.05.2012)
Published in ACS chemical biology (18.05.2012)
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Journal Article
The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b
Baumli, Sonja, Hole, Alison J., Wang, Lan-Zhen, Noble, Martin E.M., Endicott, Jane A.
Published in Structure (London) (10.10.2012)
Published in Structure (London) (10.10.2012)
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Journal Article
Structure of the Mediator Subunit Cyclin C and its Implications for CDK8 Function
Hoeppner, Sabine, Baumli, Sonja, Cramer, Patrick
Published in Journal of molecular biology (29.07.2005)
Published in Journal of molecular biology (29.07.2005)
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Journal Article
CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Bettayeb, Karima, Baunbæk, Dianne, Delehouze, Claire, Loaëc, Nadège, Hole, Alison J, Baumli, Sonja, Endicott, Jane A, Douc-Rasy, Setha, Bénard, Jean, Oumata, Nassima, Galons, Hervé, Meijer, Laurent
Published in Genes & cancer (01.04.2010)
Published in Genes & cancer (01.04.2010)
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Journal Article
The binding of flavopiridol to blood serum albumin
Myatt, Daniel, Johnson, Louise, Baumli, Sonja, Siligardi, Giuliano
Published in Chirality (New York, N.Y.) (2010)
Published in Chirality (New York, N.Y.) (2010)
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Journal Article
Abstract 697: Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as highly selective CDK9 inhibitors for cancer treatment
Shao, Hao, Foley, David, Abbas, Abdullahi Y., Hole, Alison J., Huang, Shiliang, Shi, Shenhua, Baumli, Sonja, Bradshaw, Tracey D., Noble, Martin, Endicott, Jane A., Pepper, Chris, Wang, Shudong, Fischer, Peter M.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
A Conserved Mediator Hinge Revealed in the Structure of the MED7·MED21 (Med7·Srb7) Heterodimer
Sonja Baumli, Sabine Hoeppner, Patrick Cramer
Published in The Journal of biological chemistry (06.05.2005)
Published in The Journal of biological chemistry (06.05.2005)
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Journal Article