High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
Das, Kalyan, Bauman, Joseph D, Clark, Arthur D. Jr, Frenkel, Yulia V, Lewi, Paul J, Shatkin, Aaron J, Hughes, Stephen H, Arnold, Eddy
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
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Journal Article
Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase
Kuroda, Daniel G., Bauman, Joseph D., Challa, J. Reddy, Patel, Disha, Troxler, Thomas, Das, Kalyan, Arnold, Eddy, Hochstrasser, Robin M.
Published in Nature chemistry (01.03.2013)
Published in Nature chemistry (01.03.2013)
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Journal Article
Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach
Mansouri, Mahta, Rumrill, Shawn, Dawson, Shane, Johnson, Adam, Pinson, Jo-Anne, Gunzburg, Menachem J, Latham, Catherine F, Barlow, Nicholas, Mbogo, George W, Ellenberg, Paula, Headey, Stephen J, Sluis-Cremer, Nicolas, Tyssen, David, Bauman, Joseph D, Ruiz, Francesc X, Arnold, Eddy, Chalmers, David K, Tachedjian, Gilda
Published in Molecules (Basel, Switzerland) (30.03.2023)
Published in Molecules (Basel, Switzerland) (30.03.2023)
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Journal Article
Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase
Fang, Chong, Bauman, Joseph D, Das, Kalyan, Remorino, Amanda, Arnold, Eddy, Hochstrasser, Robin M
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
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Journal Article
Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors
Bauman, Joseph D, Patel, Disha, Baker, Steven F, Vijayan, R. S. K, Xiang, Amy, Parhi, Ajit K, Martínez-Sobrido, Luis, LaVoie, Edmond J, Das, Kalyan, Arnold, Eddy
Published in ACS chemical biology (15.11.2013)
Published in ACS chemical biology (15.11.2013)
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Journal Article
Structural basis of HIV-1 resistance to AZT by excision
Arnold, Eddy, Tu, Xiongying, Das, Kalyan, Han, Qianwei, Bauman, Joseph D, Clark, Arthur D, Hou, Xiaorong, Frenkel, Yulia V, Gaffney, Barbara L, Jones, Roger A, Boyer, Paul L, Hughes, Stephen H, Sarafianos, Stefan G
Published in Nature structural & molecular biology (01.10.2010)
Published in Nature structural & molecular biology (01.10.2010)
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Journal Article
Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)
Harrison, Jerry Joe E K, Tuske, Steve, Das, Kalyan, Ruiz, Francesc X, Bauman, Joseph D, Boyer, Paul L, DeStefano, Jeffrey J, Hughes, Stephen H, Arnold, Eddy
Published in Viruses (29.07.2021)
Published in Viruses (29.07.2021)
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Journal Article
Structure of the guanylyltransferase domain of human mRNA capping enzyme
Chu, Chun, Das, Kalyan, Tyminski, James R, Bauman, Joseph D, Guan, Rongjin, Qiu, Weihua, Montelione, Gaetano T, Arnold, Eddy, Shatkin, Aaron J
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2011)
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Journal Article
Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies
Felts, Anthony K, LaBarge, Krystal, Bauman, Joseph D, Patel, Dishaben V, Himmel, Daniel M, Arnold, Eddy, Parniak, Michael A, Levy, Ronald M
Published in Journal of chemical information and modeling (22.08.2011)
Published in Journal of chemical information and modeling (22.08.2011)
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Journal Article
A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants
Johnson, Barry C, Pauly, Gary T, Rai, Ganesha, Patel, Disha, Bauman, Joseph D, Baker, Heather L, Das, Kalyan, Schneider, Joel P, Maloney, David J, Arnold, Eddy, Thomas, Craig J, Hughes, Stephen H
Published in Retrovirology (05.12.2012)
Published in Retrovirology (05.12.2012)
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Journal Article
Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer
Tuske, Steve, Zheng, Jie, Olson, Erik D., Ruiz, Francesc X., Pascal, Bruce D., Hoang, Anthony, Bauman, Joseph D., Das, Kalyan, DeStefano, Jeffrey J., Musier-Forsyth, Karin, Griffin, Patrick R., Arnold, Eddy
Published in Current research in structural biology (01.01.2020)
Published in Current research in structural biology (01.01.2020)
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Phenyl Substituted 4‑Hydroxypyridazin-3(2H)‑ones and 5‑Hydroxypyrimidin-4(3H)‑ones: Inhibitors of Influenza A Endonuclease
Sagong, Hye Yeon, Bauman, Joseph D, Patel, Disha, Das, Kalyan, Arnold, Eddy, LaVoie, Edmond J
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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Journal Article
Detecting Allosteric Sites of HIV‑1 Reverse Transcriptase by X‑ray Crystallographic Fragment Screening
Bauman, Joseph D, Patel, Disha, Dharia, Chhaya, Fromer, Marc W, Ahmed, Sameer, Frenkel, Yulia, Vijayan, R. S. K, Eck, J. Thomas, Ho, William C, Das, Kalyan, Shatkin, Aaron J, Arnold, Eddy
Published in Journal of medicinal chemistry (11.04.2013)
Published in Journal of medicinal chemistry (11.04.2013)
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Journal Article
Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site
Himmel, Daniel M., Maegley, Karen A., Pauly, Tom A., Bauman, Joseph D., Das, Kalyan, Dharia, Chhaya, Clark, Arthur D., Ryan, Kevin, Hickey, Michael J., Love, Robert A., Hughes, Stephen H., Bergqvist, Simon, Arnold, Eddy
Published in Structure (London) (09.12.2009)
Published in Structure (London) (09.12.2009)
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