Search Results - "Bauman, Jonathan N." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

by White, Tina R, Renzelman, Chad M, Rand, Arthur C, Rezai, Taha, McEwen, Cayla M, Gelev, Vladimir M, Turner, Rushia A, Linington, Roger G, Leung, Siegfried S F, Kalgutkar, Amit S, Bauman, Jonathan N, Zhang, Yizhong, Liras, Spiros, Price, David A, Mathiowetz, Alan M, Jacobson, Matthew P, Lokey, R Scott
Published in Nature chemical biology (25.09.2011)

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Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors

Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors

by Walsky, Robert L, Bauman, Jonathan N, Bourcier, Karine, Giddens, Georgina, Lapham, Kimberly, Negahban, Andre, Ryder, Tim F, Obach, R Scott, Hyland, Ruth, Goosen, Theunis C
Published in Drug metabolism and disposition (01.05.2012)

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Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug

by BAUMAN, Jonathan N, FREDERICK, Kosea S, SAWANT, Aarti, WALSKY, Robert L, COX, Loretta M, OBACH, Ronald S, KALGUTKAR, Amit S
Published in Drug metabolism and disposition (01.06.2008)

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Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen−Induced Hepatotoxicity

Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen−Induced Hepatotoxicity

by Mutlib, Abdul E, Goosen, Theunis C, Bauman, Jonathan N, Williams, J. Andrew, Kulkarni, Shaila, Kostrubsky, Seva
Published in Chemical research in toxicology (01.05.2006)

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Atorvastatin Glucuronidation Is Minimally and Nonselectively Inhibited by the Fibrates Gemfibrozil, Fenofibrate, and Fenofibric Acid

Atorvastatin Glucuronidation Is Minimally and Nonselectively Inhibited by the Fibrates Gemfibrozil, Fenofibrate, and Fenofibric Acid

by GOOSEN, Theunis C, BAUMAN, Jonathan N, DAVIS, John A, YU, Chongwoo, HURST, Susan I, WILLIAMS, J. Andrew, LOI, Cho-Ming
Published in Drug metabolism and disposition (01.08.2007)

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Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide

Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide

by Boyer, David, Bauman, Jonathan N, Walker, Daniel P, Kapinos, Brendon, Karki, Kapil, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.05.2009)

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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Ritlecitinib, a Janus Kinase 3 and Tyrosine-Protein Kinase Family Inhibitor, in Humans

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Ritlecitinib, a Janus Kinase 3 and Tyrosine-Protein Kinase Family Inhibitor, in Humans

by Bauman, Jonathan N, Doran, Angela C, Gualtieri, Gabrielle M, Hee, Brian, Strelevitz, Timothy, Cerny, Matthew A, Banfield, Christopher, Plotka, Anna, Wang, Xiaoxing, Purohit, Vivek S, Dowty, Martin E
Published in Drug metabolism and disposition (07.08.2024)

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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

by Bauman, Jonathan N, Doran, Angela C, King-Ahmad, Amanda, Sharma, Raman, Walker, Gregory S, Lin, Jian, Lin, Tsung H, Telliez, Jean-Baptiste, Tripathy, Sakambari, Goosen, Theunis C, Banfield, Christopher, Malhotra, Bimal K, Dowty, Martin E
Published in Drug metabolism and disposition (01.08.2022)

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Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies

Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies

by Walker, Gregory S, Bauman, Jonathan N, Ryder, Tim F, Smith, Evan B, Spracklin, Douglas K, Obach, R Scott
Published in Drug metabolism and disposition (01.10.2014)

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UDP-GLUCURONOSYLTRANSFERASE 2B7 IS THE MAJOR ENZYME RESPONSIBLE FOR GEMCABENE GLUCURONIDATION IN HUMAN LIVER MICROSOMES

UDP-GLUCURONOSYLTRANSFERASE 2B7 IS THE MAJOR ENZYME RESPONSIBLE FOR GEMCABENE GLUCURONIDATION IN HUMAN LIVER MICROSOMES

by BAUMAN, Jonathan N, GOOSEN, Theunis C, TUGNAIT, Meera, PETERKIN, Vincent, HURST, Susan I, MENNING, Lee C, MILAD, Mark, COURT, Michael H, WILLIAMS, J. Andrew
Published in Drug metabolism and disposition (01.09.2005)

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In Vitro Kinetic Characterization of Axitinib Metabolism

In Vitro Kinetic Characterization of Axitinib Metabolism

by Zientek, Michael A, Goosen, Theunis C, Tseng, Elaine, Lin, Jian, Bauman, Jonathan N, Walker, Gregory S, Kang, Ping, Jiang, Ying, Freiwald, Sascha, Neul, David, Smith, Bill J
Published in Drug metabolism and disposition (01.01.2016)

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The Effect of Bergamottin on Diazepam Plasma Levels and P450 Enzymes in Beagle Dogs

The Effect of Bergamottin on Diazepam Plasma Levels and P450 Enzymes in Beagle Dogs

by SAHI, Jasminder, REYNER, Eric L, BAUMAN, Jonathan N, GUENEVA-BOUCHEVA, Kristina, BURLEIGH, James E, THOMAS, V. Hayden
Published in Drug metabolism and disposition (01.02.2002)

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Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists

Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists

by KALGUTKAR, Amit S, BAUMAN, Jonathan N, MCCLURE, Kim F, AUBRECHT, Jiri, CORTINA, Santo R, PARALKAR, Janvi
Published in Bioorganic & medicinal chemistry letters (15.03.2009)

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Limited influence of UGT1A128 and no effect of UGT2B72 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

Limited influence of UGT1A128 and no effect of UGT2B72 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

by Peterkin, Vincent C., Bauman, Jonathan N., Goosen, Theunis C., Menning, Lee, Man, Michael Z., Paulauskis, Joseph D., Williams, J. Andrew, Myrand, Scott P.
Published in British journal of clinical pharmacology (01.10.2007)

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Undesired versus designed enzymatic cleavage of linkers for liver targeting

Undesired versus designed enzymatic cleavage of linkers for liver targeting

by Chirapu, Srinivas R., Bauman, Jonathan N., Eng, Heather, Goosen, Theunis C., Strelevitz, Timothy J., Sinha, Subhash C., Dow, Robert L., Finn, M. G.
Published in Bioorganic & medicinal chemistry letters (15.02.2014)

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Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2) : Structure-activity relationships and strategies for the elimination of reactive metabolite formation

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2) : Structure-activity relationships and strategies for the elimination of reactive metabolite formation

by WALKER, Daniel P, BI, F. Christopher, MCGLYNN, Molly A, OLIVER, Robert, DUNN, Matthew, LI, Jian-Cheng, RICHTER, Daniel T, COOPER, Beth A, KATH, John C, HULFORD, Catherine A, AUTRY, Christopher L, LUZZIO, Michael J, KALGUTKAR, Amit S, UNG, Ethan J, ROBERTS, W. Gregory, BONNETTE, Peter C, BUCKBINDER, Leonard, MISTRY, Anil, GRIFFOR, Matthew C, HAN, Seungil, GUZMAN-PEREZ, Angel, BAUMAN, Jonathan N, ZHAO, Sabrina X, SOGLIA, John R, ASPNES, Gary E, KUNG, Daniel W, KLUG-MCLEOD, Jacquelyn, ZAWISTOSKI, Michael P
Published in Bioorganic & medicinal chemistry (01.12.2008)

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Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis

Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis

by Kalgutkar, Amit S, Griffith, David A, Ryder, Tim, Sun, Hao, Miao, Zhuang, Bauman, Jonathan N, Didiuk, Mary T, Frederick, Kosea S, Zhao, Sabrina X, Prakash, Chandra, Soglia, John R, Bagley, Scott W, Bechle, Bruce M, Kelley, Ryan M, Dirico, Kenneth, Zawistoski, Michael, Li, Jianke, Oliver, Robert, Guzman-Perez, Angel, Liu, Kevin K. C, Walker, Daniel P, Benbow, John W, Morris, Joel
Published in Chemical research in toxicology (21.06.2010)

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Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1 -(4-Chlorobenzoyl)-5-methoxy-2-methyl-1 H-indol-3-yl)-N-phenethyl-acetamide

Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1 -(4-Chlorobenzoyl)-5-methoxy-2-methyl-1 H-indol-3-yl)-N-phenethyl-acetamide

by BOYER, David, BAUMAN, Jonathan N, WALKER, Daniel P, KAPINOS, Brendon, KARKI, Kapil, KALGUTKAR, Amit S
Published in Drug metabolism and disposition (01.05.2009)

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Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists

Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists

by Southers, James A, Bauman, Jonathan N, Price, David A, Humphries, Paul S, Balan, Gayatri, Sagal, John F, Maurer, Tristan S, Zhang, Yan, Oliver, Robert, Herr, Michael, Healy, David R, Li, Mei, Kapinos, Brendon, Fate, Gwendolyn D, Riccardi, Keith A, Paralkar, Vishwas M, Brown, Thomas A, Kalgutkar, Amit S
Published in ACS medicinal chemistry letters (12.08.2010)

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Undesired vs. Designed Enzymatic Cleavage of Linkers for Liver Targeting

Undesired vs. Designed Enzymatic Cleavage of Linkers for Liver Targeting

by Chirapu, Srinivas R., Bauman, Jonathan N., Eng, Heather, Goosen, Theunis C., Strelevitz, Timothy J., Sinha, Subhash C., Dow, Robert L., Finn, M.G.
Published in Bioorganic & medicinal chemistry letters (08.01.2014)

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