Cross Talk between the Akt and p38α Pathways in Macrophages Downstream of Toll-Like Receptor Signaling
McGuire, Victoria A., Gray, Alexander, Monk, Claire E., Santos, Susana G., Lee, Keunwook, Aubareda, Anna, Crowe, Jonathan, Ronkina, Natalia, Schwermann, Jessica, Batty, Ian H., Leslie, Nick R., Dean, Jonathan L. E., O'Keefe, Stephen J., Boothby, Mark, Gaestel, Matthias, Arthur, J. Simon C.
Published in Molecular and Cellular Biology (01.11.2013)
Published in Molecular and Cellular Biology (01.11.2013)
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Journal Article
The Lipid Phosphatase Activity of PTEN is Critical for Its Tumor Supressor Function
Myers, Michael P., Pass, Ian, Batty, Ian H., Van Der Kaay, Jeroen, Stolarov, Javor P., Hemmings, Brian A., Wigler, Michael H., Downes, C. Peter, Tonks, Nicholas K.
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.1998)
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Journal Article
Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts
Gray, Alexander, Olsson, Henric, Batty, Ian H, Priganica, Larisa, Peter Downes, C
Published in Analytical biochemistry (15.02.2003)
Published in Analytical biochemistry (15.02.2003)
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Journal Article
The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2
Batty, Ian H, van der Kaay, Jeroen, Gray, Alex, Telfer, Joan F, Dixon, Miles J, Downes, C Peter
Published in Biochemical journal (15.10.2007)
Published in Biochemical journal (15.10.2007)
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Journal Article
Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
Fleming, Ian N, Batty, Ian H, Prescott, Alan R, Gray, Alex, Kular, Gursant S, Stewart, Hazel, Downes, C Peter
Published in Biochemical journal (15.09.2004)
Published in Biochemical journal (15.09.2004)
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Journal Article
Binding of Influenza A Virus NS1 Protein to the Inter-SH2 Domain of p85β Suggests a Novel Mechanism for Phosphoinositide 3-Kinase Activation
Hale, Benjamin G., Batty, Ian H., Downes, C. Peter, Randall, Richard E.
Published in The Journal of biological chemistry (18.01.2008)
Published in The Journal of biological chemistry (18.01.2008)
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Journal Article
IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold
Dixon, Miles J., Gray, Alexander, Schenning, Martijn, Agacan, Mark, Tempel, Wolfram, Tong, Yufeng, Nedyalkova, Lyudmila, Park, Hee-Won, Leslie, Nicholas R., van Aalten, Daan M.F., Downes, C. Peter, Batty, Ian H.
Published in The Journal of biological chemistry (29.06.2012)
Published in The Journal of biological chemistry (29.06.2012)
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Journal Article
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif
Walker, Steven M, Leslie, Nick R, Perera, Nevin M, Batty, Ian H, Downes, C Peter
Published in Biochemical journal (15.04.2004)
Published in Biochemical journal (15.04.2004)
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Journal Article
A Screen for Novel Phosphoinositide 3-kinase Effector Proteins
Dixon, Miles J., Gray, Alexander, Boisvert, François-Michel, Agacan, Mark, Morrice, Nicholas A., Gourlay, Robert, Leslie, Nicholas R., Downes, C. Peter, Batty, Ian H.
Published in Molecular & cellular proteomics (01.04.2011)
Published in Molecular & cellular proteomics (01.04.2011)
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Journal Article
Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases
Leslie, Nick R., Dixon, Miles J., Schenning, Martijn, Gray, Alex, Batty, Ian H.
Published in Advances in biological regulation (01.01.2012)
Published in Advances in biological regulation (01.01.2012)
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Journal Article
Distinct Signalling Pathways Mediate Insulin and Phorbol Ester-stimulated Eukaryotic Initiation Factor 4F Assembly and Protein Synthesis in HEK 293 Cells
Herbert, Terence P., Kilhams, Gordon R., Batty, Ian H., Proud, Christopher G.
Published in The Journal of biological chemistry (14.04.2000)
Published in The Journal of biological chemistry (14.04.2000)
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Journal Article
A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets
Banfić, Hrvoje, Tang, Xiu-wen, Batty, Ian H., Downes, C. Peter, Chen, Ching-shih, Rittenhouse, Susan E.
Published in The Journal of biological chemistry (02.01.1998)
Published in The Journal of biological chemistry (02.01.1998)
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Journal Article
Mass measurements of inositol(1,4,5)trisphosphate in rat cerebral cortex slices using a radioreceptor assay: Effects of neurotransmitters and depolarization
Challiss, R.A. John, Batty, Ian H., Nahorski, Stefan R.
Published in Biochemical and biophysical research communications (15.12.1988)
Published in Biochemical and biophysical research communications (15.12.1988)
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Journal Article
A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in Vivo
van der Kaay, Jeroen, Batty, Ian H., Cross, Darren A.E., Watt, Pete W., Downes, C.Peter
Published in The Journal of biological chemistry (28.02.1997)
Published in The Journal of biological chemistry (28.02.1997)
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Journal Article
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling
LACKEY, J, BARNETT, J, DAVIDSON, L, BATTY, I. H, LESLIE, N. R, DOWNES, C. P
Published in Oncogene (01.11.2007)
Published in Oncogene (01.11.2007)
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Journal Article
Binding of Influenza A Virus NS1 Protein to the Inter-SH2 Domain of p85β Suggests a Novel Mechanism for Phosphoinositide 3-Kinase Activation
Benjamin G. Hale, Ian H. Batty, C. Peter Downes, Richard E. Randall
Published in The Journal of biological chemistry (18.01.2008)
Published in The Journal of biological chemistry (18.01.2008)
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Journal Article