Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
Batt, Sarah M, Jabeen, Talat, Bhowruth, Veemal, Quill, Lee, Lund, Peter A, Eggeling, Lothar, Alderwick, Luke J, Fütterer, Klaus, Besra, Gurdyal S
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2012)
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Journal Article
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M, Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E, Franzblau, Scott, Chatterjee, Arnab K, Johnsson, Kai, Johnson, Kai, Mikusova, Katarina, Besra, Gurdyal S, Fütterer, Klaus, Robbins, Scott H, Barnes, S Whitney, Walker, John R, Jacobs, Jr, William R, Schultz, Peter G
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
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Journal Article
Top five unanswered questions in bacterial cell wall research
Batt, Sarah M., Abrahams, Katherine A., Besra, Gurdyal S.
Published in Cell surface (Amsterdam) (01.06.2024)
Published in Cell surface (Amsterdam) (01.06.2024)
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Journal Article
Vanoxerine kills mycobacteria through membrane depolarization and efflux inhibition
Kingdon, Alexander D H, Meosa-John, Asti-Rochelle, Batt, Sarah M, Besra, Gurdyal S
Published in Frontiers in microbiology (26.01.2023)
Published in Frontiers in microbiology (26.01.2023)
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Journal Article
Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis
Singh, Manisha, Batt, Sarah M, Canales, Christian S C, Pavan, Fernando R, Kumar, Sethu Arun, Akshatha, Handattu S, Bhagyalalitha, Meduri, Pujar, Karthik G, Bidye, Durgesh, Pujar, Gurubasavaraj V, Besra, Gurdyal S
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2024)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2024)
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Journal Article
Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall
Batt, Sarah M., Burke, Christopher E., Moorey, Alice R., Besra, Gurdyal S.
Published in Cell surface (Amsterdam) (01.12.2020)
Published in Cell surface (Amsterdam) (01.12.2020)
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Journal Article
Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2
Zhang, Lu, Zhao, Yao, Gao, Ruogu, Li, Jun, Yang, Xiuna, Gao, Yan, Zhao, Wei, Gurcha, Sudagar S., Veerapen, Natacha, Batt, Sarah M., Besra, Kajelle Kaur, Xu, Wenqing, Bi, Lijun, Zhang, Xian’en, Guddat, Luke W., Yang, Haitao, Wang, Quan, Besra, Gurdyal S., Rao, Zihe
Published in Protein & cell (01.07.2020)
Published in Protein & cell (01.07.2020)
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Journal Article
The ppm operon is essential for acylation and glycosylation of lipoproteins in Corynebacterium glutamicum
Mohiman, Niloofar, Argentini, Manuela, Batt, Sarah M, Cornu, David, Masi, Muriel, Eggeling, Lothar, Besra, Gurdyal, Bayan, Nicolas
Published in PloS one (28.09.2012)
Published in PloS one (28.09.2012)
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Journal Article
The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation
Moorey, Alice R., Cabanillas, Alejandro, Batt, Sarah M., Ghidelli-Disse, Sonja, Urones, Beatriz, Sanz, Olalla, Lelievre, Joel, Bantscheff, Marcus, Cox, Liam R., Besra, Gurdyal S.
Published in Cell surface (Amsterdam) (01.12.2021)
Published in Cell surface (Amsterdam) (01.12.2021)
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Journal Article
Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities
Wang, Pengxu, Batt, Sarah M, Wang, Bin, Fu, Lei, Qin, Rongfei, Lu, Yu, Li, Gang, Besra, Gurdyal S, Huang, Haihong
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Journal Article
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol
Zhang, Lu, Zhao, Yao, Gao, Yan, Wu, Lijie, Gao, Ruogu, Zhang, Qi, Wang, Yinan, Wu, Chengyao, Wu, Fangyu, Gurcha, Sudagar S, Veerapen, Natacha, Batt, Sarah M, Zhao, Wei, Qin, Ling, Yang, Xiuna, Wang, Manfu, Zhu, Yan, Zhang, Bing, Bi, Lijun, Zhang, Xian'en, Yang, Haitao, Guddat, Luke W, Xu, Wenqing, Wang, Quan, Li, Jun, Besra, Gurdyal S, Rao, Zihe
Published in Science (American Association for the Advancement of Science) (12.06.2020)
Published in Science (American Association for the Advancement of Science) (12.06.2020)
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Journal Article
Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones
Li, Peng, Wang, Bin, Zhang, Xinwei, Batt, Sarah M., Besra, Gurdyal S., Zhang, Tingting, Ma, Chen, Zhang, Dongfeng, Lin, Ziyun, Li, Gang, Huang, Haihong, Lu, Yu
Published in European journal of medicinal chemistry (05.12.2018)
Published in European journal of medicinal chemistry (05.12.2018)
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Journal Article
Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis
Qin, Rongfei, Wang, Pengxu, Wang, Bin, Fu, Lei, Batt, Sarah M., Besra, Gurdyal S., Wu, Chengwei, Wang, Yanan, Huang, Haihong, Lu, Yu, Li, Gang
Published in European journal of medicinal chemistry (05.03.2022)
Published in European journal of medicinal chemistry (05.03.2022)
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Journal Article
Restriction Enzyme Kinetics Monitored by UV Linear Dichroism
Hicks, Matthew R, Rodger, Alison, Thomas, Christopher M, Batt, Sarah M, Dafforn, Timothy R
Published in Biochemistry (Easton) (25.07.2006)
Published in Biochemistry (Easton) (25.07.2006)
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Journal Article
Structure of the priming arabinosyltransferase AftA required for AG biosynthesis of Mycobacterium tuberculosis
Gong, Yicheng, Wei, Chuancun, Wang, Jun, Mu, Nengjiang, Lu, Qinhong, Wu, Chengyao, Yan, Ning, Yang, Huifang, Zhao, Yao, Yang, Xiuna, Gurcha, Sudagar S, Veerapen, Natacha, Batt, Sarah M, Hao, Zhiqiang, Da, Lintai, Besra, Gurdyal S, Rao, Zihe, Zhang, Lu
Published in Proceedings of the National Academy of Sciences - PNAS (06.06.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (06.06.2023)
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Journal Article
Assay development and inhibition of the Mt -DprE2 essential reductase from Mycobacterium tuberculosis
Batt, Sarah M, Toth, Szilvi, Rodriguez, Beatriz, Abrahams, Katherine A, Veerapen, Natacha, Chiodarelli, Giacomo, Cox, Liam R, Moynihan, Patrick J, Lelievre, Joel, Fütterer, Klaus, Besra, Gurdyal S
Published in Microbiology (Society for General Microbiology) (01.01.2023)
Published in Microbiology (Society for General Microbiology) (01.01.2023)
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Journal Article
A multi-targeting pre-clinical candidate against drug-resistant tuberculosis
Kaur, Parvinder, Potluri, Vijay, Ahuja, Vijay Kamal, Naveenkumar, C.N., Krishnamurthy, Ramya Vadageri, Gangadharaiah, Shruthi Thimmalapura, Shivarudraiah, Prasad, Eswaran, Sumesh, Nirmal, Christy Rosaline, Mahizhaveni, Balasubramanian, Dusthackeer, Azger, Mondal, Rajesh, Batt, Sarah M., Richardson, Emily J., Loman, Nicholas J., Besra, Gurdyal Singh, Shandil, Radha Krishan, Narayanan, Shridhar
Published in Tuberculosis (Edinburgh, Scotland) (01.07.2021)
Published in Tuberculosis (Edinburgh, Scotland) (01.07.2021)
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Journal Article
Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes
Liu, Renhe, Lyu, Xiaoxuan, Batt, Sarah M, Hsu, Mei‐Hui, Harbut, Michael B, Vilchèze, Catherine, Cheng, Bo, Ajayi, Kehinde, Yang, Baiyuan, Yang, Yun, Guo, Hui, Lin, Changyou, Gan, Fei, Wang, Chen, Franzblau, Scott G., Jacobs, William R., Besra, Gurdyal S., Johnson, Eric F., Petrassi, Mike, Chatterjee, Arnab K., Fütterer, Klaus, Wang, Feng
Published in Angewandte Chemie International Edition (09.10.2017)
Published in Angewandte Chemie International Edition (09.10.2017)
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Journal Article