Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor
Palmer, Brian D, Kraker, Alan J, Hartl, Brian G, Panopoulos, Athanasia D, Panek, Robert L, Batley, Brian L, Lu, Gina H, Trumpp-Kallmeyer, Susanne, Showalter, H. D. Hollis, Denny, William A
Published in Journal of medicinal chemistry (01.07.1999)
Published in Journal of medicinal chemistry (01.07.1999)
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In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor
Panek, R L, Lu, G H, Klutchko, S R, Batley, B L, Dahring, T K, Hamby, J M, Hallak, H, Doherty, A M, Keiser, J A
Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity
Schroeder, Mel C, Hamby, James M, Connolly, Cleo J. C, Grohar, Patrick J, Winters, R. Thomas, Barvian, Mark R, Moore, Charles W, Boushelle, Stacey L, Crean, Sheila M, Kraker, Alan J, Driscoll, Denise L, Vincent, Patrick W, Elliott, William L, Lu, Gina H, Batley, Brian L, Dahring, Tawny K, Major, Terry C, Panek, Robert L, Doherty, Annette M, Showalter, H. D. Hollis
Published in Journal of medicinal chemistry (07.06.2001)
Published in Journal of medicinal chemistry (07.06.2001)
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In Vitro Biological Characterization and Antiangiogenic Effects of PD 166866, a Selective Inhibitor of the FGF-1 Receptor Tyrosine Kinase
Panek, R L, Lu, G H, Dahring, T K, Batley, B L, Connolly, C, Hamby, J M, Brown, K J
Published in The Journal of pharmacology and experimental therapeutics (01.07.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1998)
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Inhibition of Growth Factor-Mediated Tyrosine Phosphorylation in Vascular Smooth Muscle by PD 089828, a New Synthetic Protein Tyrosine Kinase Inhibitor
Dahring, T K, Lu, G H, Hamby, J M, Batley, B L, Kraker, A J, Panek, R L
Published in The Journal of pharmacology and experimental therapeutics (01.06.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.06.1997)
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Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as Selective Inhibitors of pp60 c -src
Thompson, Andrew M, Rewcastle, Gordon W, Boushelle, Stacey L, Hartl, Brian G, Kraker, Alan J, Lu, Gina H, Batley, Brian L, Panek, Robert L, Showalter, H. D. Hollis, Denny, William A
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors
Doherty, Annette M, Sircar, Ila, Kornberg, Brian E, Quin, John, Winters, R. Thomas, Kaltenbronn, James S, Taylor, Michael D, Batley, Brian L, Rapundalo, Stephen R
Published in Journal of medicinal chemistry (01.01.1992)
Published in Journal of medicinal chemistry (01.01.1992)
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INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR
Batley, Brian L, Doherty, Annette M, Hamby, James M, Lu, Gina H, Keller, Paul, Dahring, Tawny K, Hwang, Ok, Crickard, Kent, Panek, Robert L
Published in Life sciences (1973) (1998)
Published in Life sciences (1973) (1998)
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Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors
Patt, William C, Hamilton, Harriet W, Taylor, Michael D, Ryan, Michael J, Taylor, David G, Connolly, Cleo J. C, Doherty, Annette M, Klutchko, Sylvester R, Sircar, Ila
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as Selective Inhibitors of pp60c-src
THOMPSON, Andrew M., REWCASTLE, Gordon W., BOUSHELLE, Stacey L., HARTL, Brian G., KRAKER, Alan J., LU, Gina H., BATLEY, Brian L., PANEK, Robert L., SHOWALTER, H. D. Hollis, DENNY, William A.
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors
Shahripour, Aurash, Kaltenbronn, James S, Lunney, Elizabeth A, Steinbaugh, Bruce A, Hamby, James M, Hamilton, Harriet W, Sawyer, Tomi K, Humblet, Christine, Doherty, Annette M
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P 1(→ P 3)-P 1' sites
Plummer, Mark, Hamby, James M., Hingorani, Gary, Batley, Brian L., Rapundalo, Stephen T.
Published in Bioorganic & medicinal chemistry letters (01.10.1993)
Published in Bioorganic & medicinal chemistry letters (01.10.1993)
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New inhibitors of human renin that contain novel replacements at the P2 site
Doherty, Annette M, Kaltenbronn, James S, Hudspeth, James P, Repine, Joseph T, Roark, William H, Sircar, Ila, Tinney, Frank J, Connolly, Cleo J, Hodges, John C
Published in Journal of medicinal chemistry (01.04.1991)
Published in Journal of medicinal chemistry (01.04.1991)
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Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues
Repine, Joseph T, Kaltenbronn, James S, Doherty, Annette M, Hamby, James M, Himmelsbach, Richard J, Kornberg, Brian E, Taylor, Michael D, Lunney, ELizabeth A, Humblet, Christine
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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Disparity between blood pressure and PRA inhibition after administration of a renin inhibitor to anesthetized dogs: methodological considerations
Palmer, R K, Rapundalo, S T, Batley, B L, Barnes, A E, Singh, S, Ryan, M J, Taylor, Jr, D G
Published in Clinical and experimental hypertension (1993) (01.01.1993)
Published in Clinical and experimental hypertension (1993) (01.01.1993)
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