Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases
Silacci, Michela, Lembke, Wibke, Woods, Richard, Attinger-Toller, Isabella, Baenziger-Tobler, Nadja, Batey, Sarah, Santimaria, Roger, von der Bey, Ulrike, Koenig-Friedrich, Susann, Zha, Wenjuan, Schlereth, Bernd, Locher, Mathias, Bertschinger, Julian, Grabulovski, Dragan
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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Different Members of a Simple Three-Helix Bundle Protein Family Have Very Different Folding Rate Constants and Fold by Different Mechanisms
Wensley, Beth G., Gärtner, Martina, Choo, Wan Xian, Batey, Sarah, Clarke, Jane
Published in Journal of molecular biology (31.07.2009)
Published in Journal of molecular biology (31.07.2009)
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Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain
Schlatter, Daniel, Brack, Simon, Banner, David W., Batey, Sarah, Benz, Jörg, Bertschinger, Julian, Huber, Walter, Joseph, Catherine, Rufer, Arne C., van der Klooster, Anita, Weber, Martin, Grabulovski, Dragan, Hennig, Michael
Published in mAbs (01.07.2012)
Published in mAbs (01.07.2012)
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Cooperative Folding in a Multi-domain Protein
Batey, Sarah, Randles, Lucy G., Steward, Annette, Clarke, Jane
Published in Journal of molecular biology (24.06.2005)
Published in Journal of molecular biology (24.06.2005)
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FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity
Kraman, Matthew, Faroudi, Mustapha, Allen, Natalie L, Kmiecik, Katarzyna, Gliddon, Daniel, Seal, Claire, Koers, Alexander, Wydro, Mateusz M, Batey, Sarah, Winnewisser, Julia, Young, Lesley, Tuna, Mihriban, Doody, Jacqueline, Morrow, Michelle, Brewis, Neil
Published in Clinical cancer research (01.07.2020)
Published in Clinical cancer research (01.07.2020)
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FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Exhibits Low Toxicity and Antitumor Activity in Colorectal Cancer Models
Lakins, Matthew A, Koers, Alexander, Giambalvo, Raffaella, Munoz-Olaya, Jose, Hughes, Robert, Goodman, Emma, Marshall, Sylwia, Wollerton, Francisca, Batey, Sarah, Gliddon, Daniel, Tuna, Mihriban, Brewis, Neil
Published in Clinical cancer research (01.08.2020)
Published in Clinical cancer research (01.08.2020)
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Linker Length Matters, Fynomer-Fc Fusion with an Optimized Linker Displaying Picomolar IL-17A Inhibition Potency
Silacci, Michela, Baenziger-Tobler, Nadja, Lembke, Wibke, Zha, Wenjuan, Batey, Sarah, Bertschinger, Julian, Grabulovski, Dragan
Published in The Journal of biological chemistry (16.05.2014)
Published in The Journal of biological chemistry (16.05.2014)
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The folding and evolution of multidomain proteins
Teichmann, Sarah A, Clarke, Jane, Han, Jung-Hoon, Batey, Sarah, Nickson, Adrian A
Published in Nature reviews. Molecular cell biology (01.04.2007)
Published in Nature reviews. Molecular cell biology (01.04.2007)
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Abstract 4547: Clustering CD137 via cell-expressed PD-L1 crosslinking avoided Fc-mediated agonism and resulted in safe and potent conditional lymphocyte activation
Lakins, Matthew A., Koers, Alexander, Giambalvo, Raffaella, Hughes, Robert, Marshall, Sylwia, Wydro, Mateusz, Gradinaru, Cristian, Batey, Sarah, Gliddon, Daniel, Morrow, Michelle, Brewis, Neil
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family
Clarke, Jane, Wensley, Beth G, Batey, Sarah, Bone, Fleur A. C, Chan, Zheng Ming, Tumelty, Nuala R, Steward, Annette, Kwa, Lee Gyan, Borgia, Alessandro
Published in Nature (London) (04.02.2010)
Published in Nature (London) (04.02.2010)
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Abstract 1540: FS222 mAb2, a bispecific conditional agonist antibody targeting CD137 and PD-L1, induces potent lymphocyte activation and has a favorable safety profile
Lakins, Matthew A., Koers, Alexander, Olaya, Jose Munoz, Giambalvo, Raffaella, Jones, Daniel, Pechouckova, Sarka, Goodman, Emma, Marshall, Sylwia, Wydro, Mateusz, Gradinaru, Cristian, Wollerton, Francisca, Batey, Sarah, Gliddon, Daniel, Davies, Michael, Morrow, Michelle, Tuna, Mihriban, Brewis, Neil
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis
Leung, Kin-Mei, Batey, Sarah, Rowlands, Robert, Isaac, Samine J, Jones, Phil, Drewett, Victoria, Carvalho, Joana, Gaspar, Miguel, Weller, Sarah, Medcalf, Melanie, Wydro, Mateusz M, Pegram, Robert, Mudde, Geert C, Bauer, Anton, Moulder, Kevin, Woisetschläger, Max, Tuna, Mihriban, Haurum, John S, Sun, Haijun
Published in Molecular therapy (01.11.2015)
Published in Molecular therapy (01.11.2015)
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PD-L1 및 CD137에 결합하는 항체 분자
MUNOZ OLAYA JOSE, WOLLERTON FRANCISCA, BATEY SARAH, KOERS ALEXANDER, TUNA MIHRIBAN, LAKINS MATTHEW
Year of Publication 18.03.2021
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Year of Publication 18.03.2021
Patent
Distinguishing Specific and Nonspecific Interdomain Interactions in Multidomain Proteins
Randles, Lucy G., Batey, Sarah, Steward, Annette, Clarke, Jane
Published in Biophysical journal (15.01.2008)
Published in Biophysical journal (15.01.2008)
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