Evaluation of drug‐induced QT interval prolongation in animal and human studies: a literature review of concordance
Vargas, Hugo M, Bass, Alan S, Koerner, John, Matis‐Mitchell, Sherri, Pugsley, Michael K, Skinner, Matthew, Burnham, Matthew, Bridgland‐Taylor, Matthew, Pettit, Syril, Valentin, Jean‐Pierre
Published in British journal of pharmacology (01.08.2015)
Published in British journal of pharmacology (01.08.2015)
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Journal Article
ILSI-HESI cardiovascular safety subcommittee initiative: Evaluation of three non-clinical models of QT prolongation
Hanson, Laurie A., Bass, Alan S., Gintant, Gary, Mittelstadt, Scott, Rampe, David, Thomas, Karluss
Published in Journal of pharmacological and toxicological methods (01.09.2006)
Published in Journal of pharmacological and toxicological methods (01.09.2006)
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Journal Article
Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry
Bass, Alan S., Pugsley, Michael K., Sannajust, Frederick, Yoshinaga, Takashi, Valentin, Jean-Pierre
Published in Journal of pharmacological and toxicological methods (01.07.2019)
Published in Journal of pharmacological and toxicological methods (01.07.2019)
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Journal Article
Is there a role for the no observed adverse effect level in safety pharmacology?
Mow, Tomas, Andersen, Ninette K., Dragsted, Nils, Lassen, Anders B., Laursen, Morten, Bass, Alan S., Valentin, Jean-Pierre, Markgraf, Carrie, Authier, Simon, Baird, Theodore J., Bhatt, Siddhartha, Traebert, Martin, Leishman, Derek J., Jones, David, Curtis, Michael J.
Published in Journal of pharmacological and toxicological methods (01.09.2020)
Published in Journal of pharmacological and toxicological methods (01.09.2020)
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Journal Article
Benchmarking Safety Pharmacology regulatory packages and best practice
Lindgren, Silvana, Bass, Alan S., Briscoe, Richard, Bruse, Kristy, Friedrichs, Gregory S., Kallman, Mary Jeanne, Markgraf, Carrie, Patmore, Leslie, Pugsley, Michael K.
Published in Journal of pharmacological and toxicological methods (01.09.2008)
Published in Journal of pharmacological and toxicological methods (01.09.2008)
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Journal Article
Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics
Vargas, Hugo M., Bass, Alan S., Breidenbach, Alexander, Feldman, Hal S., Gintant, Gary A., Harmer, Alexander R., Heath, Bronagh, Hoffmann, Peter, Lagrutta, Armando, Leishman, Derek, McMahon, Nick, Mittelstadt, Scott, Polonchuk, Liudmila, Pugsley, Michael K., Salata, Joseph J., Valentin, Jean-Pierre
Published in Journal of pharmacological and toxicological methods (01.09.2008)
Published in Journal of pharmacological and toxicological methods (01.09.2008)
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Journal Article
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1)
Deng, Yongqi, Yang, Zhiwei, Shipps, Gerald W., Lo, Sie-Mun, West, Robert, Hwa, Joyce, Zheng, Shuqin, Farley, Constance, Lachowicz, Jean, van Heek, Margaret, Bass, Alan S., Sinha, Dinesh P., Mahon, Craig R., Cartwright, Mark E.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
Exploratory drug safety: A discovery strategy to reduce attrition in development
Bass, Alan S., Cartwright, Mark E., Mahon, Craig, Morrison, Richard, Snyder, Ronald, McNamara, Paul, Bradley, Prudence, Zhou, Ying-Ying, Hunter, John
Published in Journal of pharmacological and toxicological methods (01.07.2009)
Published in Journal of pharmacological and toxicological methods (01.07.2009)
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Journal Article
Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society
Bass, Alan S, Vargas, Hugo M, Valentin, Jean-Pierre, Kinter, Lewis B, Hammond, Tim, Wallis, Rob, Siegl, Peter K S, Yamamoto, Keiji
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
Measuring the risk of torsades de pointes: Electrocardiographic evaluation of PNU-142093 in conscious cynomolgus non-human primates using restraint and non-restraint procedures
Bass, Alan S., Hanson, Laurie A., Jackson, Terry A.
Published in Journal of pharmacological and toxicological methods (01.07.2009)
Published in Journal of pharmacological and toxicological methods (01.07.2009)
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Journal Article
Drugs effects on ventricular repolarization: A critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices
Bass, Alan S., Tomaselli, Gordon, Bullingham, Roy, Kinter, Lewis B.
Published in Journal of pharmacological and toxicological methods (01.07.2005)
Published in Journal of pharmacological and toxicological methods (01.07.2005)
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Journal Article
ILSI–HESI cardiovascular safety subcommittee dataset: An analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc)
Chiang, Alan Y., Bass, Alan S., Cooper, Murray M., Engwall, Michael J., Menton, Ronald G., Thomas, Karluss
Published in Journal of pharmacological and toxicological methods (01.09.2007)
Published in Journal of pharmacological and toxicological methods (01.09.2007)
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Journal Article
Safety pharmacology in 2010 and beyond: Survey of significant events of the past 10years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society
Bass, Alan S., Vargas, Hugo M., Valentin, Jean-Pierre, Kinter, Lewis B., Hammond, Tim, Wallis, Rob, Siegl, Peter K.S., Yamamoto, Keiji
Published in Journal of pharmacological and toxicological methods (01.07.2011)
Published in Journal of pharmacological and toxicological methods (01.07.2011)
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Journal Article
Evaluation of QTc prolongation in animal and human studies: A qualitative assessment of nonclinical and clinical concordance based on the literature
Vargas, Hugo M., Bass, Alan S., Koerner, John, Matis-Mitchell, Sherri, Pugsley, Michael K., Skinner, Matt, Burnham, Matthew, Pettit, Syril, Valentin, Jean Pierre
Published in Journal of pharmacological and toxicological methods (01.09.2012)
Published in Journal of pharmacological and toxicological methods (01.09.2012)
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Journal Article
Cardiac toxicity assessment and its relation to plasma level in various conscious animals
Gao, Yu-Jing, Zhou, Ying-Ying, Yvon, Alexandra, Sorota, Steve, Tedesco, Rechard, Pula, Kathryn, Beaughard, Michele, Kaijser, Gerry, Bass, Alan S., Friendrichs, Gregory S.
Published in Journal of pharmacological and toxicological methods (01.09.2010)
Published in Journal of pharmacological and toxicological methods (01.09.2010)
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Journal Article