Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential
Aleo, Michael D, Shah, Falgun, Allen, Scott, Barton, Hugh A, Costales, Chester, Lazzaro, Sarah, Leung, Louis, Nilson, Andrea, Obach, R. Scott, Rodrigues, A. David, Will, Yvonne
Published in Chemical research in toxicology (21.01.2020)
Published in Chemical research in toxicology (21.01.2020)
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Journal Article
Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data
Jones, Hannah M, Barton, Hugh A, Lai, Yurong, Bi, Yi-An, Kimoto, Emi, Kempshall, Sarah, Tate, Sonya C, El-Kattan, Ayman, Houston, J Brian, Galetin, Aleksandra, Fenner, Katherine S
Published in Drug metabolism and disposition (01.05.2012)
Published in Drug metabolism and disposition (01.05.2012)
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Journal Article
Physiologically based pharmacokinetic prediction of telmisartan in human
Li, Rui, Ghosh, Avijit, Maurer, Tristan S, Kimoto, Emi, Barton, Hugh A
Published in Drug metabolism and disposition (01.10.2014)
Published in Drug metabolism and disposition (01.10.2014)
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Journal Article
A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data
Jones, Hannah M., Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Avery, Lindsay B., King, Lindsay E., Neubert, Hendrik, Barton, Hugh A., Betts, Alison M., Webster, Robert
Published in CPT: pharmacometrics and systems pharmacology (01.10.2019)
Published in CPT: pharmacometrics and systems pharmacology (01.10.2019)
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Journal Article
A “middle-out” approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling
Li, Rui, Barton, Hugh A., Yates, Phillip D., Ghosh, Avijit, Wolford, Angela C., Riccardi, Keith A., Maurer, Tristan S.
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2014)
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2014)
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Journal Article
In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation
Bi, Yi-An, Kimoto, Emi, Sevidal, Samantha, Jones, Hannah M, Barton, Hugh A, Kempshall, Sarah, Whalen, Kevin M, Zhang, Hui, Ji, Chengjie, Fenner, Katherine S, El-Kattan, Ayman F, Lai, Yurong
Published in Drug metabolism and disposition (01.06.2012)
Published in Drug metabolism and disposition (01.06.2012)
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Journal Article
On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach
Haddish-Berhane, Nahor, Shah, Dhaval K., Ma, Dangshe, Leal, Mauricio, Gerber, Hans-Peter, Sapra, Puja, Barton, Hugh A., Betts, Alison M.
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2013)
Published in Journal of pharmacokinetics and pharmacodynamics (01.10.2013)
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Journal Article
Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice
Lou, Inchio, Wambaugh, John F., Lau, Christopher, Hanson, Roger G., Lindstrom, Andrew B., Strynar, Mark J., Zehr, R. Dan, Setzer, R. Woodrow, Barton, Hugh A.
Published in Toxicological sciences (01.02.2009)
Published in Toxicological sciences (01.02.2009)
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Journal Article
The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance
Fenner, Katherine S., Jones, Hannah M., Ullah, Mohammed, Kempshall, Sarah, Dickins, Maurice, Lai, Yurong, Morgan, Paul, Barton, Hugh A.
Published in Xenobiotica (01.01.2012)
Published in Xenobiotica (01.01.2012)
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Journal Article
Evaluation of Oral and Intravenous Route Pharmacokinetics, Plasma Protein Binding, and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach
Teeguarden, Justin G., Waechter, John M., Clewell, Harvey J., Covington, Tammie R., Barton, Hugh A.
Published in Toxicological sciences (01.06.2005)
Published in Toxicological sciences (01.06.2005)
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Journal Article
Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment
Meek, M.E. (Bette), Barton, Hugh A., Bessems, Jos G., Lipscomb, John C., Krishnan, Kannan
Published in Regulatory toxicology and pharmacology (01.06.2013)
Published in Regulatory toxicology and pharmacology (01.06.2013)
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Journal Article
Database for Physiologically Based Pharmacokinetic (PBPK) Modeling: Physiological Data for Healthy and Health-Impaired Elderly
Thompson, Chad M., Johns, Douglas O., Sonawane, Babasaheb, Barton, Hugh A., Hattis, Dale, Tardif, Robert, Krishnan, Kannan
Published in Journal of toxicology and environmental health. Part B, Critical reviews (01.01.2009)
Published in Journal of toxicology and environmental health. Part B, Critical reviews (01.01.2009)
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Journal Article
Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity
Generaux, Grant, Lakhani, Vinal V., Yang, Yuching, Nadanaciva, Sashi, Qiu, Luping, Riccardi, Keith, Di, Li, Howell, Brett A., Siler, Scott Q., Watkins, Paul B., Barton, Hugh A., Aleo, Michael D., Shoda, Lisl K. M.
Published in Pharmacology research & perspectives (01.12.2019)
Published in Pharmacology research & perspectives (01.12.2019)
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Journal Article
Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays
Shah, Falgun, Leung, Louis, Barton, Hugh A, Will, Yvonne, Rodrigues, A David, Greene, Nigel, Aleo, Michael D
Published in Toxicological sciences (01.10.2015)
Published in Toxicological sciences (01.10.2015)
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