Randomized Trial of 2 Delayed-Release Formulations of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
Chey, William D, Sayuk, Gregory S, Bartolini, Wilmin, Reasner, David S, Fox, Susan M, Bochenek, Wieslaw, Boinpally, Ramesh, Shea, Elizabeth, Tripp, Kenneth, Borgstein, Niels
Published in The American journal of gastroenterology (01.02.2021)
Published in The American journal of gastroenterology (01.02.2021)
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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
Busby, Robert W., Bryant, Alexander P., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Mahajan-Miklos, Shalina, Pierce, Christine M., Solinga, Robert M., Sun, Li Jing, Tobin, Jenny V., Kurtz, Caroline B., Currie, Mark G.
Published in European journal of pharmacology (15.12.2010)
Published in European journal of pharmacology (15.12.2010)
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Journal Article
Linaclotide Reduced Response Time for Irritable Bowel Syndrome With Constipation Symptoms: Analysis of 4 Randomized Controlled Trials
Brenner, Darren M, Lacy, Brian E, Ford, Alexander C, Bartolini, Wilmin, Wu, James, Shea, Elizabeth P, Bochenek, Wieslaw, Boinpally, Ramesh, Almansa, Cristina
Published in The American journal of gastroenterology (01.05.2023)
Published in The American journal of gastroenterology (01.05.2023)
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S529 Linaclotide Improves Symptoms of Irritable Bowel Syndrome With Constipation, Irrespective of Severity and Age: A Post-Hoc Analysis of Pooled Trials
Chang, Lin, Houghton, Lesley A., Ford, Alexander C., Bartolini, Wilmin, Wu, James, Shea, Elizabeth P., Bochenek, Wieslaw, Boinpally, Ramesh, Almansa, Cristina
Published in The American journal of gastroenterology (01.10.2021)
Published in The American journal of gastroenterology (01.10.2021)
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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation
Busby, Robert W, Kessler, Marco M, Bartolini, Wilmin P, Bryant, Alexander P, Hannig, Gerhard, Higgins, Carolyn S, Solinga, Robert M, Tobin, Jenny V, Wakefield, James D, Kurtz, Caroline B, Currie, Mark G
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2013)
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S510 Time to Relief of Key Abdominal and Bowel Symptoms of Irritable Bowel Syndrome with Constipation: A Post-Hoc Analysis of Randomized Controlled Trials of Linaclotide
Brenner, Darren M., Lacy, Brian E., Ford, Alexander C., Bartolini, Wilmin, Wu, James, Shea, Elizabeth P., Bochenek, Wieslaw, Boinpally, Ramesh, Almansa, Cristina
Published in The American journal of gastroenterology (01.10.2021)
Published in The American journal of gastroenterology (01.10.2021)
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Journal Article
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
Bryant, Alexander P., Busby, Robert W., Bartolini, Wilmin P., Cordero, Etchell A., Hannig, Gerhard, Kessler, Marco M., Pierce, Christine M., Solinga, Robert M., Tobin, Jenny V., Mahajan-Miklos, Shalina, Cohen, Mitchell B., Kurtz, Caroline B., Currie, Mark G.
Published in Life sciences (1973) (08.05.2010)
Published in Life sciences (1973) (08.05.2010)
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Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease
Johnston, Tom H, Huot, Philippe, Fox, Susan H, Wakefield, James D, Sykes, Kristine A, Bartolini, Wilmin P, Milne, G Todd, Pearson, James P, Brotchie, Jonathan M
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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497 MD-7246, a Delayed-Release Formulation of Linaclotide Targeting Visceral Pain Associated With IBS-D, Does Not Impact Bowel Frequency or Stool Consistency in Healthy Volunteers: Results From Phase I Trial
Kuo, Braden, Bartolini, Wilmin, Tripp, Kenneth, Boinpally, Ramesh, Borgstein, Niels
Published in The American journal of gastroenterology (01.10.2019)
Published in The American journal of gastroenterology (01.10.2019)
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A first-in-human study of IK-595, an oral MEK/RAF molecular glue, in patients with RAS- or RAF-altered advanced solid tumors
Lakhani, Nehal J., Spira, Alexander I., Tolcher, Anthony W., Lingaraj, Trupti, Timothy, Marissa, Bartolini, Wilmin, Ortiz-Otero, Nerymar, Kacena, Katherine, Santillana, Sergio
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
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Efficacy of Linaclotide in Reducing Abdominal Symptoms of Bloating, Discomfort, and Pain: A Phase 3B Trial Using a Novel Abdominal Scoring System
Chang, Lin, Lacy, Brian E, Moshiree, Baha, Kassebaum, Amy, Abel, Jessica L, Hanlon, Jennifer, Bartolini, Wilmin, Boinpally, Ramesh, Bochenek, Wieslaw, Fox, Susan M, Mallick, Madhuja, Tripp, Ken, Omniewski, Nicholas, Shea, Elizabeth, Borgstein, Niels
Published in The American journal of gastroenterology (01.09.2021)
Published in The American journal of gastroenterology (01.09.2021)
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S0469 Linaclotide Improves Abdominal Symptoms Regardless of Baseline IBS Symptom Severity: A Post-Hoc Analysis of a Phase 3b Trial
Sayuk, Gregory S., Chang, Lin, Bartolini, Wilmin, Li, Ella, Fox, Susan, Shea, Elizabeth, Boinpally, Ramesh, Bochenek, Wieslaw, Borgstein, Niels
Published in The American journal of gastroenterology (01.10.2020)
Published in The American journal of gastroenterology (01.10.2020)
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Intestinal Guanylate Cyclase‐C mRNA Expression in Duodenum and Colon of Children
Cohen, Mitchell B., Gold, Benjamin D., Xanthakos, Stavra A., CaJacob, Nicholas, Weissman, Taryn, Bartolini, Wilmin, Boinpally, Ramesh, Mallick, Madhuja, Reasner, David S., O'Dea, Christopher R., Kwak, Hanna, Ge, Pei
Published in Journal of pediatric gastroenterology and nutrition (01.12.2021)
Published in Journal of pediatric gastroenterology and nutrition (01.12.2021)
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Mo1550 A NOVEL SCORE TO EVALUATE ABDOMINAL SYMPTOM IMPROVEMENT IN PATIENTS WITH CONSTIPATION-PREDOMINANT IBS DEMONSTRATES EFFICACY OF LINACLOTIDE FOR IMPROVING ABDOMINAL BLOATING, DISCOMFORT, AND PAIN IN A PHASE 3B TRIAL
Chang, Lin, Lacy, Brian E., Moshiree, Baha, Kassebaum, Amy, Abel, Jessica L., Hanlon, Jennifer, Bartolini, Wilmin, Boinpally, Ramesh, Bochenek, Wieslaw, Fox, Susan M., Mallick, Madhuja, Tripp, Ken, Omniewski, Nicholas, Shea, Elizabeth P., Borgstein, Niels
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
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Tu1638 - Reliabilty of, and Agreement Between, Rome III and Rome IV Irritable Bowel Syndrome (IBS) Subtyping by Means of Stool Diary
Palsson, Olafur S., Simren, Magnus, Higgins, Carolyn S., Fox, Susan M., Johnston, Jeffrey M., Bochenek, Wieslaw, Bartolini, Wilmin, Tripp, Kenneth J., Whitehead, William E.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
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Identification of single stranded regions of DNA by enzymatic digestion with matrix-assisted laser desorption/ionization analysis
Bartolini, Wilmin P., Bentzley, Catherine M., Johnston, Murray V., Larsen, Barbara S.
Published in Journal of the American Society for Mass Spectrometry (01.06.1999)
Published in Journal of the American Society for Mass Spectrometry (01.06.1999)
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Abstract 2156: IK-930 is a novel TEAD inhibitor for the treatment of cancers harboring mutations in the Hippo signal transduction pathway
Amidon, Benjamin S., Sanchez-Martin, Marta, Bartolini, Wilmin, Syed, Sakeena, McGovern, Karen, Xu, Lan, Ecsedy, Jeffrey, Zhang, X. Michelle, Constan, Alex, Castro, Alfredo C.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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