Genomics of disease risk in globally diverse populations
Gurdasani, Deepti, Barroso, Inês, Zeggini, Eleftheria, Sandhu, Manjinder S
Published in Nature reviews. Genetics (01.09.2019)
Published in Nature reviews. Genetics (01.09.2019)
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Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila
Agrawal, Neha, Lawler, Katherine, Davidson, Catherine M, Keogh, Julia M, Legg, Robert, Barroso, Inês, Farooqi, I Sadaf, Brand, Andrea H
Published in PLoS biology (01.11.2021)
Published in PLoS biology (01.11.2021)
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Prospective functional classification of all possible missense variants in PPARG
Majithia, Amit R, Tsuda, Ben, Agostini, Maura, Gnanapradeepan, Keerthana, Rice, Robert, Peloso, Gina, Patel, Kashyap A, Zhang, Xiaolan, Broekema, Marjoleine F, Patterson, Nick, Duby, Marc, Sharpe, Ted, Kalkhoven, Eric, Rosen, Evan D, Barroso, Inês, Ellard, Sian, Kathiresan, Sekar, O'Rahilly, Stephen, Chatterjee, Krishna, Florez, Jose C, Mikkelsen, Tarjei, Savage, David B, Altshuler, David
Published in Nature genetics (01.12.2016)
Published in Nature genetics (01.12.2016)
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Genetic architecture of human thinness compared to severe obesity
Riveros-McKay, Fernando, Mistry, Vanisha, Bounds, Rebecca, Hendricks, Audrey, Keogh, Julia M, Thomas, Hannah, Henning, Elana, Corbin, Laura J, O'Rahilly, Stephen, Zeggini, Eleftheria, Wheeler, Eleanor, Barroso, Inês, Farooqi, I Sadaf
Published in PLoS genetics (24.01.2019)
Published in PLoS genetics (24.01.2019)
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Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations
Nica, Alexandra C, Montgomery, Stephen B, Dimas, Antigone S, Stranger, Barbara E, Beazley, Claude, Barroso, Inês, Dermitzakis, Emmanouil T
Published in PLoS genetics (01.04.2010)
Published in PLoS genetics (01.04.2010)
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A linear mixed-model approach to study multivariate gene-environment interactions
Moore, Rachel, Casale, Francesco Paolo, Jan Bonder, Marc, Horta, Danilo, Franke, Lude, Barroso, Inês, Stegle, Oliver
Published in Nature genetics (01.01.2019)
Published in Nature genetics (01.01.2019)
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Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance
van der Klaauw, Agatha A., Croizier, Sophie, Mendes de Oliveira, Edson, Stadler, Lukas K.J., Park, Soyoung, Kong, Youxin, Banton, Matthew C., Tandon, Panna, Hendricks, Audrey E., Keogh, Julia M., Riley, Susanna E., Papadia, Sofia, Henning, Elana, Bounds, Rebecca, Bochukova, Elena G., Mistry, Vanisha, O’Rahilly, Stephen, Simerly, Richard B., Minchin, James E.N., Barroso, Inês, Jones, E. Yvonne, Bouret, Sebastien G., Farooqi, I. Sadaf
Published in Cell (07.02.2019)
Published in Cell (07.02.2019)
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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
BONNEFOND, Amélie, CLEMENT, Nathalie, HERCBERG, Serge, HADJADJ, Samy, BALKAU, Beverley, MARRE, Michel, LANTIERI, Olivier, LANGENBERG, Claudia, BOUATIA-NAJI, Nabila, CHARPENTIER, Guillaume, VAXILLAIRE, Martine, ROCHELEAU, Ghislain, FAWCETT, Katherine, WAREHAM, Nicholas J, SLADEK, Robert, MCCARTHY, Mark I, DINA, Christian, BARROSO, Ines, JOCKERS, Ralf, FROGUEL, Philippe, YENGO, Loïc, VAILLANT, Emmanuel, GUILLAUME, Jean-Luc, DECHAUME, Aurélie, PAYNE, Felicity, ROUSSEL, Ronan, CZERNICHOW, Sébastien
Published in Nature genetics (01.03.2012)
Published in Nature genetics (01.03.2012)
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Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis
Murphy, Neil, Song, Mingyang, Papadimitriou, Nikos, Carreras-Torres, Robert, Langenberg, Claudia, Martin, Richard M, Tsilidis, Konstantinos K, Barroso, Inês, Chen, Ji, Frayling, Timothy M, Bull, Caroline J, Vincent, Emma E, Cotterchio, Michelle, Gruber, Stephen B, Pai, Rish K, Newcomb, Polly A, Perez-Cornago, Aurora, van Duijnhoven, Franzel J B, Van Guelpen, Bethany, Vodicka, Pavel, Wolk, Alicja, Wu, Anna H, Peters, Ulrike, Chan, Andrew T, Gunter, Marc J
Published in JNCI : Journal of the National Cancer Institute (09.05.2022)
Published in JNCI : Journal of the National Cancer Institute (09.05.2022)
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Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
Lotta, Luca A, Gulati, Pawan, Day, Felix R, Payne, Felicity, Ongen, Halit, van de Bunt, Martijn, Gaulton, Kyle J, Eicher, John D, Sharp, Stephen J, Luan, Jian'an, De Lucia Rolfe, Emanuella, Stewart, Isobel D, Wheeler, Eleanor, Willems, Sara M, Adams, Claire, Yaghootkar, Hanieh, Forouhi, Nita G, Khaw, Kay-Tee, Johnson, Andrew D, Semple, Robert K, Frayling, Timothy, Perry, John R B, Dermitzakis, Emmanouil, McCarthy, Mark I, Barroso, Inês, Wareham, Nicholas J, Savage, David B, Langenberg, Claudia, O'Rahilly, Stephen, Scott, Robert A
Published in Nature genetics (01.01.2017)
Published in Nature genetics (01.01.2017)
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Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities
Sonoyama, Takuhiro, Stadler, Lukas K J, Zhu, Mingyan, Keogh, Julia M, Henning, Elana, Hisama, Fuki, Kirwan, Peter, Jura, Magdalena, Blaszczyk, Beata K, DeWitt, David C, Brouwers, Bas, Hyvönen, Marko, Barroso, Inês, Merkle, Florian T, Appleyard, Suzanne M, Wayman, Gary A, Farooqi, I Sadaf
Published in Scientific reports (03.06.2020)
Published in Scientific reports (03.06.2020)
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Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy
Gandotra, Sheetal, Le Dour, Caroline, Bottomley, William, Cervera, Pascale, Giral, Philippe, Reznik, Yves, Charpentier, Guillaume, Auclair, Martine, Delépine, Marc, Barroso, Inês, Semple, Robert K, Lathrop, Mark, Lascols, Olivier, Capeau, Jacqueline, O'Rahilly, Stephen, Magré, Jocelyne, Savage, David B, Vigouroux, Corinne
Published in The New England journal of medicine (24.02.2011)
Published in The New England journal of medicine (24.02.2011)
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Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease
Payne, Felicity, Lim, Koini, Girousse, Amandine, Brown, Rebecca J., Kory, Nora, Robbins, Ann, Xue, Yali, Sleigh, Alison, Cochran, Elaine, Adams, Claire, Borman, Arundhati Dev, Russel-Jones, David, Gorden, Phillip, Semple, Robert K., Saudek, Vladimir, O'Rahilly, Stephen, Walther, Tobias C., Barroso, Inês, Savage, David B.
Published in Proceedings of the National Academy of Sciences - PNAS (17.06.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (17.06.2014)
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Genetic Factors in Type 2 Diabetes: The End of the Beginning?
O'Rahilly, Stephen, Barroso, Inês, Wareham, Nicholas J.
Published in Science (American Association for the Advancement of Science) (21.01.2005)
Published in Science (American Association for the Advancement of Science) (21.01.2005)
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Mendelian Randomization Analysis of Hemoglobin A1c as a Risk Factor for Coronary Artery Disease
Leong, Aaron, Chen, Ji, Wheeler, Eleanor, Hivert, Marie-France, Liu, Ching-Ti, Merino, Jordi, Dupuis, Josée, Tai, E Shyong, Rotter, Jerome I., Florez, Jose C., Barroso, Inês, Meigs, James B.
Published in Diabetes care (01.07.2019)
Published in Diabetes care (01.07.2019)
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Obesity-Associated GNAS Mutations and the Melanocortin Pathway
Mendes de Oliveira, Edson, Keogh, Julia M, Talbot, Fleur, Henning, Elana, Ahmed, Rachel, Perdikari, Aliki, Bounds, Rebecca, Wasiluk, Natalia, Ayinampudi, Vikram, Barroso, Inês, Mokrosiński, Jacek, Jyothish, Deepthi, Lim, Sharon, Gupta, Sanjay, Kershaw, Melanie, Matei, Cristina, Partha, Praveen, Randell, Tabitha, McAulay, Antoinette, Wilson, Louise C, Cheetham, Tim, Crowne, Elizabeth C, Clayton, Peter, Farooqi, I. Sadaf
Published in The New England journal of medicine (21.10.2021)
Published in The New England journal of medicine (21.10.2021)
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Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance
Payne, Felicity, Colnaghi, Rita, Rocha, Nuno, Seth, Asha, Harris, Julie, Carpenter, Gillian, Bottomley, William E, Wheeler, Eleanor, Wong, Stephen, Saudek, Vladimir, Savage, David, O'Rahilly, Stephen, Carel, Jean-Claude, Barroso, Inês, O'Driscoll, Mark, Semple, Robert
Published in The Journal of clinical investigation (01.09.2014)
Published in The Journal of clinical investigation (01.09.2014)
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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Lotta, Luca A, Scott, Robert A, Sharp, Stephen J, Burgess, Stephen, Luan, Jian'an, Tillin, Therese, Schmidt, Amand F, Imamura, Fumiaki, Stewart, Isobel D, Perry, John R B, Marney, Luke, Koulman, Albert, Karoly, Edward D, Forouhi, Nita G, Sjögren, Rasmus J O, Näslund, Erik, Zierath, Juleen R, Krook, Anna, Savage, David B, Griffin, Julian L, Chaturvedi, Nishi, Hingorani, Aroon D, Khaw, Kay-Tee, Barroso, Inês, McCarthy, Mark I, O'Rahilly, Stephen, Wareham, Nicholas J, Langenberg, Claudia
Published in PLoS medicine (29.11.2016)
Published in PLoS medicine (29.11.2016)
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