Application of structure-metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties
Humphreys, W. G., Obermeier, M. T., Barrish, J. C., Chong, S., Marino, A. M., Murugesan, N., Wang-Iverson, D., Morrison, R. A.
Published in Xenobiotica (01.11.2003)
Published in Xenobiotica (01.11.2003)
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Discovery and Preclinical Studies of (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an In Vivo Active Potent VEGFR-2 Inhibitor
Bhide, Rajeev S, Cai, Zhen-Wei, Zhang, Yong-Zheng, Qian, Ligang, Wei, Donna, Barbosa, Stephanie, Lombardo, Louis J, Borzilleri, Robert M, Zheng, Xiaoping, Wu, Laurence I, Barrish, Joel C, Kim, Soong-Hoon, Leavitt, Kenneth, Mathur, Arvind, Leith, Leslie, Chao, Sam, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Kukral, Daniel, Hunt, John T, Kamath, Amrita, Fura, Aberra, Vyas, Viral, Marathe, Punit, D'Arienzo, Celia, Derbin, George, Fargnoli, Joseph
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Antiviral properties of aminodiol inhibitors against human immunodeficiency virus and protease
BECHTOLD, C. M, PATICK, A. K, COLONNO, R, GREYTOK, J, TINO, J. A, CHEN, P, GORDON, E, AHMAD, S, BARRISH, J. C, ZAHLER, R, LIN, P.-F
Published in Antimicrobial Agents and Chemotherapy (01.02.1995)
Published in Antimicrobial Agents and Chemotherapy (01.02.1995)
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Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor
Patick, A K, Rose, R, Greytok, J, Bechtold, C M, Hermsmeier, M A, Chen, P T, Barrish, J C, Zahler, R, Colonno, R J, Lin, P F
Published in Journal of Virology (01.04.1995)
Published in Journal of Virology (01.04.1995)
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Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors
Borzilleri, Robert M, Zheng, Xiaoping, Qian, Ligang, Ellis, Christopher, Cai, Zhen-wei, Wautlet, Barri S, Mortillo, Steve, Jeyaseelan, Robert, Kukral, Daniel W, Fura, Aberra, Kamath, Amrita, Vyas, Viral, Tokarski, John S, Barrish, Joel C, Hunt, John T, Lombardo, Louis J, Fargnoli, Joseph, Bhide, Rajeev S
Published in Journal of medicinal chemistry (16.06.2005)
Published in Journal of medicinal chemistry (16.06.2005)
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Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists
Murugesan, N, Gu, Z, Stein, P D, Spergel, S, Mathur, A, Leith, L, Liu, E C, Zhang, R, Bird, E, Waldron, T, Marino, A, Morrison, R A, Webb, M L, Moreland, S, Barrish, J C
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Journal Article
Remote diastereoselection in the asymmetric total synthesis of mevinolin
Wovkulich, Peter M, Tang, P. C, Chadha, N. K, Batcho, A. D, Barrish, J. C, Uskokovic, M. R
Published in Journal of the American Chemical Society (01.03.1989)
Published in Journal of the American Chemical Society (01.03.1989)
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Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists
Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D, Spergel, Steven, Mathur, Arvind, Leith, Leslie, Liu, Eddie C.-K, Zhang, Rongan, Bird, Eileen, Waldron, Tom, Marino, Anthony, Morrison, Richard A, Webb, Maria L, Moreland, Suzanne, Barrish, Joel C
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Aminodiol HIV Protease Inhibitors. Synthesis And Structure−Activity Relationships Of P1/P1‘ Compounds: Correlation between Lipophilicity and Cytotoxicity
Chen, Ping, Cheng, Peter T. W, Alam, Masud, Beyer, Barbara D, Bisacchi, Gregory S, Dejneka, Tamara, Evans, Adelaide J, Greytok, Jill A, Hermsmeier, Mark A, Humphreys, W. Griffith, Jacobs, Glenn A, Kocy, Octavian, Lin, Pin-Fang, Lis, Karen A, Marella, Michael A, Ryono, Denis E, Sheaffer, Amy K, Spergel, Steven H, Sun, Chong-qing, Tino, Joseph A, Vite, Gregory, Colonno, Richard J, Zahler, Robert, Barrish, Joel C
Published in Journal of medicinal chemistry (10.05.1996)
Published in Journal of medicinal chemistry (10.05.1996)
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Biphenylsulfonamide Endothelin Antagonists: Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino-N- (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)
Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D, Bisaha, Sharon, Spergel, Steve, Girotra, Ravi, Lee, Ving G, Lloyd, John, Misra, Raj N, Schmidt, Joan, Mathur, Arvind, Stratton, Leslie, Kelly, Yolanda F, Bird, Eileen, Waldron, Tom, Liu, Eddie C.-K, Zhang, Rongan, Lee, Helen, Serafino, Randy, Abboa-Offei, Benoni, Mathers, Parker, Giancarli, Mary, Seymour, Andrea Ann, Webb, Maria L, Moreland, Suzanne, Barrish, Joel C, Hunt, John T
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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AMINODIOL HIV PROTEASE INHIBITORS .1. DESIGN, SYNTHESIS, AND PRELIMINARY SAR
BARRISH, JC, GORDON, E, ALAM, M, LIN, PF, BISACCHI, GS, CHEN, P, CHENG, PTW, FRITZ, AW, GREYTOK, JA, HERMSMEIER, MA, HUMPHREYS, WG, LIS, KA, MARELLA, MA, MERCHANT, Z, MITT, T, MORRISON, RA, OBERMEIER, MT, PLUSCEC, J, SKOOG, M, SLUSARCHYK, WA, SPERGEL, SH, STEVENSON, JM, SUN, CQ, SUNDEEN, JE, TAUNK, P, TINO, JA, WARRACK, BM, COLONNO, RJ, ZAHLER, R
Published in Journal of medicinal chemistry (10.06.1994)
Published in Journal of medicinal chemistry (10.06.1994)
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Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists
Misra, Raj N, Brown, Baerbel R, Sher, Philip M, Patel, Manorama M, Hall, Steven E, Han, Wen Ching, Barrish, Joel C, Kocy, Octavian, Harris, Don N
Published in Journal of medicinal chemistry (01.05.1993)
Published in Journal of medicinal chemistry (01.05.1993)
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Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays
Lombardo, Louis J, Lee, Francis Y, Chen, Ping, Norris, Derek, Barrish, Joel C, Behnia, Kamelia, Castaneda, Stephen, Cornelius, Lyndon A. M, Das, Jagabandhu, Doweyko, Arthur M, Fairchild, Craig, Hunt, John T, Inigo, Ivan, Johnston, Kathy, Kamath, Amrita, Kan, David, Klei, Herbert, Marathe, Punit, Pang, Suhong, Peterson, Russell, Pitt, Sidney, Schieven, Gary L, Schmidt, Robert J, Tokarski, John, Wen, Mei-Li, Wityak, John, Borzilleri, Robert M
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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Total synthesis of pseudomonic acid C
Barrish, Joel C, Lee, Hsi Lin, Mitt, Toomas, Pizzolato, Giacomo, Baggiolini, Enrico G, Uskokovic, Milan R
Published in Journal of organic chemistry (01.09.1988)
Published in Journal of organic chemistry (01.09.1988)
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AN APPROACH TO THE SYNTHESIS OF THE HEXAHYDRONAPHTHALENE UNIT OF PRAVASTATIN
BARRISH, JC, WOVKULICH, PM, TANG, PC, BATCHO, AD, USKOKOVIC, MR
Published in Tetrahedron letters (01.01.1990)
Published in Tetrahedron letters (01.01.1990)
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A new approach to the total synthesis of pseudomonic acid C
Barrish, Joel C, Lee, Hsi Lin, Baggiolini, Enrico G, Uskokovic, Milan R
Published in Journal of organic chemistry (01.04.1987)
Published in Journal of organic chemistry (01.04.1987)
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Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl) -piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxam (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays
Lombardo, L J, Lee, F Y, Chen, P, Norris, D, Barrish, J C, Behnia, K, Castaneda, S, Cornelius, LAM, Das, J, Doweyko, A M, Fairchild, C, Hunt, J T, Inigo, I
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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A new facile method for the synthesis of 1-arylimidazole-5-carboxylates
Chen, Bang-Chi, Bednarz, Mark S, Zhao, Rulin, Sundeen, Joseph E, Chen, Ping, Shen, Zhongqi, Skoumbourdis, Amanda P, Barrish, Joel C
Published in Tetrahedron letters (15.07.2000)
Published in Tetrahedron letters (15.07.2000)
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Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors
Das, Jagabandhu, Moquin, Robert V, Lin, James, Liu, Chunjian, Doweyko, Arthur M, DeFex, Henry F, Fang, Qiong, Pang, Suhong, Pitt, Sidney, Shen, Ding Ren, Schieven, Gary L, Barrish, Joel C, Wityak, John
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
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