The Immunoscore: Colon Cancer and Beyond
Angell, Helen K, Bruni, Daniela, Barrett, J Carl, Herbst, Ronald, Galon, Jérôme
Published in Clinical cancer research (15.01.2020)
Published in Clinical cancer research (15.01.2020)
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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research
Lai, Zhongwu, Markovets, Aleksandra, Ahdesmaki, Miika, Chapman, Brad, Hofmann, Oliver, McEwen, Robert, Johnson, Justin, Dougherty, Brian, Barrett, J Carl, Dry, Jonathan R
Published in Nucleic acids research (20.06.2016)
Published in Nucleic acids research (20.06.2016)
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Osimertinib As First-Line Treatment of EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer
Ramalingam, Suresh S, Yang, James C-H, Lee, Chee Khoon, Kurata, Takayasu, Kim, Dong-Wan, John, Thomas, Nogami, Naoyuki, Ohe, Yuichiro, Mann, Helen, Rukazenkov, Yuri, Ghiorghiu, Serban, Stetson, Daniel, Markovets, Aleksandra, Barrett, J Carl, Thress, Kenneth S, Jänne, Pasi A
Published in Journal of clinical oncology (20.03.2018)
Published in Journal of clinical oncology (20.03.2018)
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EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291
Thress, Kenneth S, Brant, Roz, Carr, T. Hedley, Dearden, Simon, Jenkins, Suzanne, Brown, Helen, Hammett, Tracey, Cantarini, Mireille, Barrett, J. Carl
Published in Lung cancer (Amsterdam, Netherlands) (01.12.2015)
Published in Lung cancer (Amsterdam, Netherlands) (01.12.2015)
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Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M
Thress, Kenneth S, Paweletz, Cloud P, Felip, Enriqueta, Cho, Byoung Chul, Stetson, Daniel, Dougherty, Brian, Lai, Zhongwu, Markovets, Aleksandra, Vivancos, Ana, Kuang, Yanan, Ercan, Dalia, Matthews, Sarah E, Cantarini, Mireille, Barrett, J Carl, Jänne, Pasi A, Oxnard, Geoffrey R
Published in Nature medicine (01.06.2015)
Published in Nature medicine (01.06.2015)
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Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers
Vaclova, Tereza, Grazini, Ursula, Ward, Lewis, O’Neill, Daniel, Markovets, Aleksandra, Huang, Xiangning, Chmielecki, Juliann, Hartmaier, Ryan, Thress, Kenneth S., Smith, Paul D., Barrett, J. Carl, Downward, Julian, de Bruin, Elza C.
Published in Nature communications (19.03.2021)
Published in Nature communications (19.03.2021)
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A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA -Mutated Breast and Gynecologic Cancers
Banerji, Udai, Dean, Emma J, Pérez-Fidalgo, J Alejandro, Batist, Gerald, Bedard, Philippe L, You, Benoit, Westin, Shannon N, Kabos, Peter, Garrett, Michelle D, Tall, Mathew, Ambrose, Helen, Barrett, J Carl, Carr, T Hedley, Cheung, S Y Amy, Corcoran, Claire, Cullberg, Marie, Davies, Barry R, de Bruin, Elza C, Elvin, Paul, Foxley, Andrew, Lawrence, Peter, Lindemann, Justin P O, Maudsley, Rhiannon, Pass, Martin, Rowlands, Vicky, Rugman, Paul, Schiavon, Gaia, Yates, James, Schellens, Jan H M
Published in Clinical cancer research (01.05.2018)
Published in Clinical cancer research (01.05.2018)
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Rare variant contribution to human disease in 281,104 UK Biobank exomes
Wang, Quanli, Dhindsa, Ryan S., Carss, Keren, Harper, Andrew R., Nag, Abhishek, Tachmazidou, Ioanna, Vitsios, Dimitrios, Deevi, Sri V. V., Mackay, Alex, Muthas, Daniel, Hühn, Michael, Monkley, Susan, Olsson, Henric, Wasilewski, Sebastian, Smith, Katherine R., March, Ruth, Platt, Adam, Haefliger, Carolina, Petrovski, Slavé
Published in Nature (London) (23.09.2021)
Published in Nature (London) (23.09.2021)
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Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization
Lheureux, Stephanie, Lai, Zhongwu, Dougherty, Brian A, Runswick, Sarah, Hodgson, Darren R, Timms, Kirsten M, Lanchbury, Jerry S, Kaye, Stan, Gourley, Charlie, Bowtell, David, Kohn, Elise C, Scott, Claire, Matulonis, Ursula, Panzarella, Tony, Karakasis, Katherine, Burnier, Julia V, Gilks, C Blake, O'Connor, Mark J, Robertson, Jane D, Ledermann, Jonathan, Barrett, J Carl, Ho, Tony W, Oza, Amit M
Published in Clinical cancer research (01.08.2017)
Published in Clinical cancer research (01.08.2017)
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Impact of a five-dimensional framework on R&D productivity at AstraZeneca
Morgan, Paul, Brown, Dean G., Lennard, Simon, Anderton, Mark J., Barrett, J. Carl, Eriksson, Ulf, Fidock, Mark, Hamrén, Bengt, Johnson, Anthony, March, Ruth E., Matcham, James, Mettetal, Jerome, Nicholls, David J., Platz, Stefan, Rees, Steve, Snowden, Michael A., Pangalos, Menelas N.
Published in Nature reviews. Drug discovery (01.03.2018)
Published in Nature reviews. Drug discovery (01.03.2018)
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Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples
Veldman-Jones, Margaret H, Brant, Roz, Rooney, Claire, Geh, Catherine, Emery, Hollie, Harbron, Chris G, Wappett, Mark, Sharpe, Alan, Dymond, Michael, Barrett, J Carl, Harrington, Elizabeth A, Marshall, Gayle
Published in Cancer research (Chicago, Ill.) (01.07.2015)
Published in Cancer research (Chicago, Ill.) (01.07.2015)
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Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial
Ledermann, Jonathan, Prof, Harter, Philipp, MD, Gourley, Charlie, Prof, Friedlander, Michael, Prof, Vergote, Ignace, Prof, Rustin, Gordon, Prof, Scott, Clare L, PhD, Meier, Werner, Prof, Shapira-Frommer, Ronnie, MD, Safra, Tamar, MD, Matei, Daniela, MD, Fielding, Anitra, MBChB, Spencer, Stuart, MSc, Dougherty, Brian, PhD, Orr, Maria, PhD, Hodgson, Darren, PhD, Barrett, J Carl, PhD, Matulonis, Ursula, MD
Published in The lancet oncology (01.07.2014)
Published in The lancet oncology (01.07.2014)
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Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes
Hodgson, Darren R., Dougherty, Brian A., Lai, Zhongwu, Fielding, Anitra, Grinsted, Lynda, Spencer, Stuart, O’Connor, Mark J., Ho, Tony W., Robertson, Jane D., Lanchbury, Jerry S., Timms, Kirsten M., Gutin, Alexander, Orr, Maria, Jones, Helen, Gilks, Blake, Womack, Chris, Gourley, Charlie, Ledermann, Jonathan, Barrett, J. Carl
Published in British journal of cancer (27.11.2018)
Published in British journal of cancer (27.11.2018)
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Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer
Chmielecki, Juliann, Gray, Jhanelle E., Cheng, Ying, Ohe, Yuichiro, Imamura, Fumio, Cho, Byoung Chul, Lin, Meng-Chih, Majem, Margarita, Shah, Riyaz, Rukazenkov, Yuri, Todd, Alexander, Markovets, Aleksandra, Barrett, J. Carl, Hartmaier, Ryan J., Ramalingam, Suresh S.
Published in Nature communications (27.02.2023)
Published in Nature communications (27.02.2023)
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Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial
Chmielecki, Juliann, Mok, Tony, Wu, Yi-Long, Han, Ji-Youn, Ahn, Myung-Ju, Ramalingam, Suresh S., John, Thomas, Okamoto, Isamu, Yang, James Chih-Hsin, Shepherd, Frances A., Bulusu, Krishna C., Laus, Gianluca, Collins, Barbara, Barrett, J. Carl, Hartmaier, Ryan J., Papadimitrakopoulou, Vassiliki
Published in Nature communications (27.02.2023)
Published in Nature communications (27.02.2023)
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Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project
Merino, Diana M, McShane, Lisa M, Fabrizio, David, Funari, Vincent, Chen, Shu-Jen, White, James R, Wenz, Paul, Baden, Jonathan, Barrett, J Carl, Chaudhary, Ruchi, Chen, Li, Chen, Wangjuh (Sting), Cheng, Jen-Hao, Cyanam, Dinesh, Dickey, Jennifer S, Gupta, Vikas, Hellmann, Matthew, Helman, Elena, Li, Yali, Maas, Joerg, Papin, Arnaud, Patidar, Rajesh, Quinn, Katie J, Rizvi, Naiyer, Tae, Hongseok, Ward, Christine, Xie, Mingchao, Zehir, Ahmet, Zhao, Chen, Dietel, Manfred, Stenzinger, Albrecht, Stewart, Mark, Allen, Jeff
Published in Journal for immunotherapy of cancer (01.03.2020)
Published in Journal for immunotherapy of cancer (01.03.2020)
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Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response
Willis, Sophie E., Winkler, Claudia, Roudier, Martine P., Baird, Tarrion, Marco-Casanova, Paola, Jones, Emma V., Rowe, Philip, Rodriguez-Canales, Jaime, Angell, Helen K., Ng, Felicia S. L., Waring, Paul M., Hodgson, Darren, Ledermann, Jonathan A., Weberpals, Johanne I., Dean, Emma, Harrington, Elizabeth A., Barrett, J. Carl, Pierce, Andrew J., Leo, Elisabetta, Jones, Gemma N.
Published in British journal of cancer (07.12.2021)
Published in British journal of cancer (07.12.2021)
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Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial
Oza, Amit M, Prof, Cibula, David, Prof, Benzaquen, Ana Oaknin, MD, Poole, Christopher, Prof, Mathijssen, Ron H J, Prof, Sonke, Gabe S, MD, Colombo, Nicoletta, MD, Špaček, Jiří, MD, Vuylsteke, Peter, MD, Hirte, Holger, MD, Mahner, Sven, MD, Plante, Marie, MD, Schmalfeldt, Barbara, Prof, Mackay, Helen, MD, Rowbottom, Jacqui, PhD, Lowe, Elizabeth S, MD, Dougherty, Brian, PhD, Barrett, J Carl, PhD, Friedlander, Michael, Prof
Published in The lancet oncology (2015)
Published in The lancet oncology (2015)
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Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition
Vaclova, Tereza, Chakraborty, Atanu, Sherwood, James, Ross, Sarah, Carroll, Danielle, Barrett, J. Carl, Downward, Julian, de Bruin, Elza C.
Published in Scientific reports (17.02.2022)
Published in Scientific reports (17.02.2022)
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Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response
Sidders, Ben, Zhang, Pei, Goodwin, Kelly, O'Connor, Greg, Russell, Deanna L, Borodovsky, Alexandra, Armenia, Joshua, McEwen, Robert, Linghu, Bolan, Bendell, Johanna C, Bauer, Todd M, Patel, Manish R, Falchook, Gerald S, Merchant, Melinda, Pouliot, Gayle, Barrett, J Carl, Dry, Jonathan R, Woessner, Rich, Sachsenmeier, Kris
Published in Clinical cancer research (01.05.2020)
Published in Clinical cancer research (01.05.2020)
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