Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
Carayol, Nathalie, Vakana, Eliza, Sassano, Antonella, Kaur, Surinder, Goussetis, Dennis J., Glaser, Heather, Druker, Brian J., Donato, Nicholas J., Altman, Jessica K., Barr, Sharon, Platanias, Leonidas C., Stark, George R.
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2010)
Get full text
Journal Article
Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors
FALCON, Beverly L, BARR, Sharon, GOKHALE, Prafulla C, CHOU, Jeyling, FOGARTY, Jennifer, DEPEILLE, Philippe, MIGLARESE, Mark, EPSTEIN, David M, MCDONALD, Donald M
Published in Cancer research (Chicago, Ill.) (01.03.2011)
Published in Cancer research (Chicago, Ill.) (01.03.2011)
Get full text
Journal Article
Dual mTORC2/mTORC1 Targeting Results in Potent Suppressive Effects on Acute Myeloid Leukemia (AML) Progenitors
ALTMAN, Jessica K, SASSANO, Antonella, KAUR, Surinder, GLASER, Heather, KROCZYNSKA, Barbara, REDIG, Amanda J, RUSSO, Suzanne, BARR, Sharon, PLATANIAS, Leonidas C
Published in Clinical cancer research (01.07.2011)
Published in Clinical cancer research (01.07.2011)
Get full text
Journal Article
Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors
Buck, Elizabeth, Eyzaguirre, Alexandra, Rosenfeld-Franklin, Maryland, Thomson, Stuart, Mulvihill, Mark, Barr, Sharon, Brown, Eric, O'Connor, Mathew, Yao, Yan, Pachter, Jonathan, Miglarese, Mark, Epstein, David, Iwata, Kenneth K, Haley, John D, Gibson, Neil W, Ji, Qun-Sheng
Published in Cancer research (Chicago, Ill.) (15.10.2008)
Published in Cancer research (Chicago, Ill.) (15.10.2008)
Get full text
Journal Article
Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies
Gupta, Mamta, Hendrickson, Andrea E. Wahner, Yun, Seong Seok, Han, Jing Jing, Schneider, Paula A., Koh, Brian D., Stenson, Mary J., Wellik, Linda E., Shing, Jennifer C., Peterson, Kevin L., Flatten, Karen S., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Barr, Sharon, Witzig, Thomas E., Kaufmann, Scott H.
Published in Blood (12.01.2012)
Published in Blood (12.01.2012)
Get full text
Journal Article
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
Buck, Elizabeth, Eyzaguirre, Alexandra, Barr, Sharon, Thompson, Stuart, Sennello, Regina, Young, David, Iwata, Kenneth K, Gibson, Neil W, Cagnoni, Pablo, Haley, John D
Published in Molecular cancer therapeutics (01.02.2007)
Published in Molecular cancer therapeutics (01.02.2007)
Get full text
Journal Article
Targeting TORC1/2 Enhances Sensitivity to EGFR Inhibitors in Head and Neck Cancer Preclinical Models
Cassell, Andre, Freilino, Maria L, Lee, Jessica, Barr, Sharon, Wang, Lin, Panahandeh, Mary C, Thomas, Sufi M, Grandis, Jennifer R
Published in Neoplasia (New York, N.Y.) (01.11.2012)
Published in Neoplasia (New York, N.Y.) (01.11.2012)
Get full text
Journal Article
ATR Kinase Activity Regulates the Intranuclear Translocation of ATR and RPA following Ionizing Radiation
Barr, Sharon M., Leung, Cindy G., Chang, Elbert E., Cimprich, Karlene A.
Published in Current biology (17.06.2003)
Published in Current biology (17.06.2003)
Get full text
Journal Article
Plasma‐Soluble Biomarkers for Fibrodysplasia Ossificans Progressiva (FOP) Reflect Acute and Chronic Inflammatory States
Pignolo, Robert J, McCarrick‐Walmsley, Ruth, Wang, Haitao, Qiu, Shirley, Hunter, Jeffrey, Barr, Sharon, He, Kevin, Zhang, Hui, Kaplan, Frederick S
Published in Journal of bone and mineral research (01.03.2022)
Published in Journal of bone and mineral research (01.03.2022)
Get full text
Journal Article
An ensemble approach to accurately detect somatic mutations using SomaticSeq
Fang, Li Tai, Afshar, Pegah Tootoonchi, Chhibber, Aparna, Mohiyuddin, Marghoob, Fan, Yu, Mu, John C, Gibeling, Greg, Barr, Sharon, Asadi, Narges Bani, Gerstein, Mark B, Koboldt, Daniel C, Wang, Wenyi, Wong, Wing H, Lam, Hugo Y K
Published in Genome Biology (17.09.2015)
Published in Genome Biology (17.09.2015)
Get full text
Journal Article
A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies
Mateo, Joaquin, Olmos, David, Dumez, Herlinde, Poondru, Srinivasu, Samberg, Nancy L, Barr, Sharon, Van Tornout, Jan M, Jie, Fei, Sandhu, Shahneen, Tan, Daniel S, Moreno, Victor, LoRusso, Patricia M, Kaye, Stan B, Schöffski, Patrick
Published in British journal of cancer (12.04.2016)
Published in British journal of cancer (12.04.2016)
Get full text
Journal Article
Activation of the JC Virus Tat-Responsive Transcriptional Control Element by Association of the Tat Protein of Human Immunodeficiency Virus 1 with Cellular Protein Purα
Krachmarov, Chavdar P., Chepenik, Lara G., Barr-Vagell, Sharon, Khalili, Kamel, Johnson, Edward M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.11.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (26.11.1996)
Get full text
Journal Article
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions
Barr, Sharon, Thomson, Stuart, Buck, Elizabeth, Russo, Suzanne, Petti, Filippo, Sujka-Kwok, Izabela, Eyzaguirre, Alexandra, Rosenfeld-Franklin, Maryland, Gibson, Neil W., Miglarese, Mark, Epstein, David, Iwata, Kenneth K., Haley, John D.
Published in Clinical & experimental metastasis (2008)
Published in Clinical & experimental metastasis (2008)
Get full text
Journal Article
Abstract A2: Selective inhibition of mTORC1/mTORC2 sensitizes prostate cancer cells to the effects of AR or IGF-1R/IR antagonists, providing an approach to overcome intrinsic mechanisms of resistance
O'Connor, Matthew, Buck, Elizabeth, Thomson, Stuart, Epstein, David, Mark, Miglarese, Barr, Sharon
Published in Clinical cancer research (15.05.2012)
Published in Clinical cancer research (15.05.2012)
Get full text
Journal Article
Abstract 1632: Co-targeting mTOR and IGF-1R/IR results in synergistic activity against a broad array of tumor cell lines, independent of KRAS mutation status
Barr, Sharon, Russo, Suzanne, Buck, Elizabeth, Epstein, David, Miglarese, Mark
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Get full text
Journal Article
Abstract B1: Dual mTORC1/mTORC2 inhibition limits tumor growth, VEGF production and vascular regrowth
Barr, Sharon, Falcon, Beverly L., Ghokale, Prafulla C., Chou, Jeyling, Fogarty, Jennifer, Depeille, Philippe, Miglarese, Mark, Epstein, David M.
Published in Clinical cancer research (15.05.2012)
Published in Clinical cancer research (15.05.2012)
Get full text
Journal Article
Targeting TORC1/2 Enhances Sensitivity to EGFR Inhibitors in Head and Neck Cancer Preclinical Models1
Cassell, Andre, Freilino, Maria L, Lee, Jessica, Barr, Sharon, Wang, Lin, Panahandeh, Mary C, Thomas, Sufi M, Grandis, Jennifer R
Published in Neoplasia (New York, N.Y.) (01.11.2012)
Get full text
Published in Neoplasia (New York, N.Y.) (01.11.2012)
Journal Article
Abstract 2403: Proteomic profiling of signaling pathways in LKB1 deficient non-small cell lung cancers (NSCLC) identifies novel therapeutic targets including IGF1R pathway
Byers, Lauren Averett, Cortez, Maria Angelica, Yang, Chao, Wang, Jing, Diao, Lixia, Fan, You Hong, Girard, Luc, Gazdar, Adi, Wistuba, Ignacio, Minna, John D., O'Connor, Matthew, Barr, Sharon, Heymach, John V.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article