Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag
Hudak, Jason E., Barfield, Robyn M., de Hart, Gregory W., Grob, Patricia, Nogales, Eva, Bertozzi, Carolyn R., Rabuka, David
Published in Angewandte Chemie (International ed.) (23.04.2012)
Published in Angewandte Chemie (International ed.) (23.04.2012)
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Journal Article
Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells
Bauzon, Maxine, Drake, Penelope M, Barfield, Robyn M, Cornali, Brandon M, Rupniewski, Igor, Rabuka, David
Published in Oncoimmunology (01.01.2019)
Published in Oncoimmunology (01.01.2019)
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Journal Article
Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer
Harel, Efrat T, Drake, Penelope M, Barfield, Robyn M, Lui, Irene, Farr-Jones, Shauna, Van't Veer, Laura, Gartner, Zev J, Green, Evan M, Lourenço, André Luiz, Cheng, Yifan, Hann, Byron C, Rabuka, David, Craik, Charles S
Published in Antibodies (Basel) (05.11.2019)
Published in Antibodies (Basel) (05.11.2019)
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Journal Article
Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications
Linz, Thomas, Yeo, Dominick, Hong, Qiuting, Zmolek, Wesley, McFarland, Jesse, Barfield, Robyn, Haskins, William, Rabuka, David
Published in Antibodies (Basel) (01.12.2018)
Published in Antibodies (Basel) (01.12.2018)
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Journal Article
Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes
Drake, Penelope M, Albers, Aaron E, Baker, Jeanne, Banas, Stefanie, Barfield, Robyn M, Bhat, Abhijit S, de Hart, Gregory W, Garofalo, Albert W, Holder, Patrick, Jones, Lesley C, Kudirka, Romas, McFarland, Jesse, Zmolek, Wes, Rabuka, David
Published in Bioconjugate chemistry (16.07.2014)
Published in Bioconjugate chemistry (16.07.2014)
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Journal Article
Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates
Chuprakov, Stepan, Ogunkoya, Ayodele O, Barfield, Robyn M, Bauzon, Maxine, Hickle, Colin, Kim, Yun Cheol, Yeo, Dominick, Zhang, Fangjiu, Rabuka, David, Drake, Penelope M
Published in Bioconjugate chemistry (21.04.2021)
Published in Bioconjugate chemistry (21.04.2021)
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Journal Article
Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates
Agarwal, Paresh, Kudirka, Romas, Albers, Aaron E, Barfield, Robyn M, de Hart, Gregory W, Drake, Penelope M, Jones, Lesley C, Rabuka, David
Published in Bioconjugate chemistry (19.06.2013)
Published in Bioconjugate chemistry (19.06.2013)
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Journal Article
CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity
Tsui, C Kimberly, Barfield, Robyn M, Fischer, Curt R, Morgens, David W, Li, Amy, Smith, Benjamin A H, Gray, Melissa Anne, Bertozzi, Carolyn R, Rabuka, David, Bassik, Michael C
Published in Nature chemical biology (01.10.2019)
Published in Nature chemical biology (01.10.2019)
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Journal Article
Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion
Holder, Patrick G., Jones, Lesley C., Drake, Penelope M., Barfield, Robyn M., Bañas, Stefanie, de Hart, Gregory W., Baker, Jeanne, Rabuka, David
Published in The Journal of biological chemistry (19.06.2015)
Published in The Journal of biological chemistry (19.06.2015)
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Journal Article
A Novel HER2-targeted Antibody–drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels
Barfield, Robyn M., Kim, Yun Cheol, Chuprakov, Stepan, Zhang, Fangjiu, Bauzon, Maxine, Ogunkoya, Ayodele O., Yeo, Dominick, Hickle, Colin, Pegram, Mark D., Rabuka, David, Drake, Penelope M.
Published in Molecular cancer therapeutics (01.09.2020)
Published in Molecular cancer therapeutics (01.09.2020)
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Journal Article
A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations
Zmolek, Wesley, Bañas, Stefanie, Barfield, Robyn M., Rabuka, David, Drake, Penelope M.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2016)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.10.2016)
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Journal Article
CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models
Drake, Penelope M, Carlson, Adam, McFarland, Jesse M, Bañas, Stefanie, Barfield, Robyn M, Zmolek, Wesley, Kim, Yun Cheol, Huang, Betty C B, Kudirka, Romas, Rabuka, David
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates
Albers, Aaron E., Garofalo, Albert W., Drake, Penelope M., Kudirka, Romas, de Hart, Gregory W., Barfield, Robyn M., Baker, Jeanne, Banas, Stefanie, Rabuka, David
Published in European journal of medicinal chemistry (17.12.2014)
Published in European journal of medicinal chemistry (17.12.2014)
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Journal Article
Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)
York, Dona, Baker, Jeanne, Holder, Patrick G, Jones, Lesley C, Drake, Penelope M, Barfield, Robyn M, Bleck, Gregory T, Rabuka, David
Published in BMC biotechnology (24.02.2016)
Published in BMC biotechnology (24.02.2016)
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Journal Article
Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions
Huang, Betty C B, Kim, Yun Cheol, Bañas, Stefanie, Barfield, Robyn M, Drake, Penelope M, Rupniewski, Igor, Haskins, William E, Rabuka, David
Published in mAbs (17.11.2018)
Published in mAbs (17.11.2018)
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Journal Article
Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates
Kudirka, Romas A, Barfield, Robyn M, McFarland, Jesse M, Drake, Penelope M, Carlson, Adam, Bañas, Stefanie, Zmolek, Wes, Garofalo, Albert W, Rabuka, David
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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Journal Article
Phosphorylation of Chs2p regulates interaction with COPII
Jakobsen, Mia Kyed, Cheng, Zhiliang, Lam, Sheung Kwan, Roth-Johnson, Elizabeth, Barfield, Robyn M, Schekman, Randy
Published in Journal of cell science (15.05.2013)
Published in Journal of cell science (15.05.2013)
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