Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Clare, Rachel H., Bardelle, Catherine, Harper, Paul, Hong, W. David, Börjesson, Ulf, Johnston, Kelly L., Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A. N., Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L., Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G., O’Neill, Paul M., Taylor, Mark J., Ward, Stephen A.
Published in Nature communications (02.01.2019)
Published in Nature communications (02.01.2019)
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Journal Article
Screening for molecular glues – Challenges and opportunities
Holdgate, Geoffrey A., Bardelle, Catherine, Berry, Sophia K., Lanne, Alice, Cuomo, Maria Emanuela
Published in SLAS discovery (01.03.2024)
Published in SLAS discovery (01.03.2024)
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Journal Article
High-throughput flow cytometry for drug discovery: principles, applications, and case studies
Ding, Mei, Kaspersson, Karin, Murray, David, Bardelle, Catherine
Published in Drug discovery today (01.12.2017)
Published in Drug discovery today (01.12.2017)
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Journal Article
Drug discovery for epigenetics targets
Holdgate, Geoffrey A, Bardelle, Catherine, Lanne, Alice, Read, Jon, O'Donovan, Daniel H, Smith, James M, Selmi, Nidhal, Sheppard, Robert
Published in Drug discovery today (01.04.2022)
Published in Drug discovery today (01.04.2022)
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Journal Article
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models
Winter-Holt, Jon J, Bardelle, Catherine, Chiarparin, Elisabetta, Dale, Ian L, Davey, Paul R. J, Davies, Nichola L, Denz, Christopher, Fillery, Shaun M, Guérot, Carine M, Han, Fujin, Hughes, Samantha J, Kulkarni, Meghana, Liu, Zhaoqun, Milbradt, Alexander, Moss, Thomas A, Niu, Huijun, Patel, Joe, Rabow, Alfred A, Schimpl, Marianne, Shi, Junjie, Sun, Dongqing, Yang, Dejian, Guichard, Sylvie
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Journal Article
Application of High-Throughput Flow Cytometry in Early Drug Discovery: An AstraZeneca Perspective
Ding, Mei, Clark, Roger, Bardelle, Catherine, Backmark, Anna, Norris, Tyrrell, Williams, Wendy, Wigglesworth, Mark, Howes, Rob
Published in SLAS discovery (01.08.2018)
Published in SLAS discovery (01.08.2018)
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Journal Article
Validation of miniaturized one-step reverse transcription qPCR assays for high-throughput screening and comparison to a reporter gene methodology
Bardelle, Catherine, McWilliams, Lisa, Mounfield, Susan, Wigglesworth, Mark, Rich, Kirsty
Published in Assay and drug development technologies (01.03.2015)
Published in Assay and drug development technologies (01.03.2015)
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Journal Article
Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors To Explore a MEK Resistance Hypothesis
Kettle, Jason G, Ballard, Peter, Bardelle, Catherine, Cockerill, Mark, Colclough, Nicola, Critchlow, Susan E, Debreczeni, Judit, Fairley, Gary, Fillery, Shaun, Graham, Mark A, Goodwin, Louise, Guichard, Sylvie, Hudson, Kevin, Ward, Richard A, Whittaker, David
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Journal Article
Abstract 3041: Blood-brain barrier penetrating ATM inhibitor (AZ32) radiosensitises intracranial gliomas in mice
Durant, Steve T., Karlin, Jeremy, Pike, Kurt, Colclough, Nicola, Mukhopadhyay, N, Ahmad, S F., Bekta, J M., Tokarz, M, Bardelle, Catherine, Hughes, Gareth, Patel, Bhavika, Thomason, Andrew, Cadogan, Elaine, Barrett, Ian, Lau, Alan, Pass, Martin, Valerie, Kristoffer
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors
Bardelle, Catherine, Barlaam, Bernard, Brooks, Nigel, Coleman, Tanya, Cross, Darren, Ducray, Richard, Green, Isabelle, Brempt, Christine Lambert-van der, Olivier, Annie, Read, Jon
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Journal Article
Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series
Barlaam, Bernard, Ducray, Richard, Brempt, Christine Lambert-van der, Plé, Patrick, Bardelle, Catherine, Brooks, Nigel, Coleman, Tanya, Cross, Darren, Kettle, Jason G., Read, Jon
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
Development of a High-Throughput Cytometric Screen to Identify Anti-Wolbachia Compounds: The Power of Public–Private Partnership
Clare, Rachel H., Clark, Roger, Bardelle, Catherine, Harper, Paul, Collier, Matthew, Johnston, Kelly L., Plant, Helen, Plant, Darren, McCall, Eileen, Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Ford, Louise, Murray, David, Rich, Kirsty, Wigglesworth, Mark, Taylor, Mark J., Ward, Stephen A.
Published in SLAS discovery (01.06.2019)
Published in SLAS discovery (01.06.2019)
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Journal Article
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4- bis-anilinopyrimidines
Bardelle, Catherine, Cross, Darren, Davenport, Sara, Kettle, Jason G., Ko, Eun Jung, Leach, Andrew G., Mortlock, Andrew, Read, Jon, Roberts, Nicola J., Robins, Peter, Williams, Emma J.
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
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Journal Article
Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5- bis substituted anilinopyrimidines
Bardelle, Catherine, Coleman, Tanya, Cross, Darren, Davenport, Sara, Kettle, Jason G., Ko, Eun Jung, Leach, Andrew G., Mortlock, Andrew, Read, Jon, Roberts, Nicola J., Robins, Peter, Williams, Emma J.
Published in Bioorganic & medicinal chemistry letters (01.11.2008)
Published in Bioorganic & medicinal chemistry letters (01.11.2008)
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Journal Article
The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach
Allen, Joanne V., Bardelle, Catherine, Blades, Kevin, Buttar, Dave, Chapman, Louise, Colclough, Nicola, Dossetter, Alexander G., Garner, Andrew P., Girdwood, Alan, Lambert, Christine, Leach, Andrew G., Law, Brian, Major, John, Plant, Helen, Slater, Anthony M.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article