Challenges and recent progress in drug discovery for tropical diseases
De Rycker, Manu, Baragaña, Beatriz, Duce, Suzanne L., Gilbert, Ian H.
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
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Journal Article
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
Baragaña, Beatriz, Norcross, Neil R, Wilson, Caroline, Porzelle, Achim, Hallyburton, Irene, Grimaldi, Raffaella, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C, Wyatt, Paul G, Delves, Michael J, Meister, Stephan, Duffy, Sandra, Avery, Vicky M, Winzeler, Elizabeth A, Sinden, Robert E, Wittlin, Sergio, Frearson, Julie A, Gray, David W, Fairlamb, Alan H, Waterson, David, Campbell, Simon F, Willis, Paul, Read, Kevin D, Gilbert, Ian H
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Journal Article
MalDA, Accelerating Malaria Drug Discovery
Yang, Tuo, Ottilie, Sabine, Istvan, Eva S., Godinez-Macias, Karla P., Lukens, Amanda K., Baragaña, Beatriz, Campo, Brice, Walpole, Chris, Niles, Jacquin C., Chibale, Kelly, Dechering, Koen J., Llinás, Manuel, Lee, Marcus C.S., Kato, Nobutaka, Wyllie, Susan, McNamara, Case W., Gamo, Francisco Javier, Burrows, Jeremy, Fidock, David A., Goldberg, Daniel E., Gilbert, Ian H., Wirth, Dyann F., Winzeler, Elizabeth A.
Published in Trends in parasitology (01.06.2021)
Published in Trends in parasitology (01.06.2021)
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Journal Article
Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation
Michalska, Karolina, Jedrzejczak, Robert, Wower, Jacek, Chang, Changsoo, Baragaña, Beatriz, Gilbert, Ian H, Forte, Barbara, Joachimiak, Andrzej
Published in Nucleic acids research (21.05.2021)
Published in Nucleic acids research (21.05.2021)
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Journal Article
Prioritization of Molecular Targets for Antimalarial Drug Discovery
Forte, Barbara, Ottilie, Sabine, Plater, Andrew, Campo, Brice, Dechering, Koen J, Gamo, Francisco Javier, Goldberg, Daniel E, Istvan, Eva S, Lee, Marcus, Lukens, Amanda K, McNamara, Case W, Niles, Jacquin C, Okombo, John, Pasaje, Charisse Flerida A, Siegel, Miles G, Wirth, Dyann, Wyllie, Susan, Fidock, David A, Baragaña, Beatriz, Winzeler, Elizabeth A, Gilbert, Ian H
Published in ACS infectious diseases (08.10.2021)
Published in ACS infectious diseases (08.10.2021)
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Journal Article
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium
Hanna, Jack C, Corpas-Lopez, Victor, Seizova, Simona, Colon, Beatrice L, Bacchetti, Ross, Hall, Grant M J, Sands, Emma M, Robinson, Lee, Baragaña, Beatriz, Wyllie, Susan, Pawlowic, Mattie C
Published in Frontiers in cellular and infection microbiology (04.08.2023)
Published in Frontiers in cellular and infection microbiology (04.08.2023)
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Journal Article
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
Green, Simon R., Wilson, Caroline, Eadsforth, Thomas C., Punekar, Avinash S., Tamaki, Fabio K., Wood, Gavin, Caldwell, Nicola, Forte, Barbara, Norcross, Neil R., Kiczun, Michael, Post, John M., Lopez-Roman, Eva Maria, Engelhart, Curtis A., Lukac, Iva, Zuccotto, Fabio, Epemolu, Ola, Boshoff, Helena I. M., Schnappinger, Dirk, Walpole, Chris, Gilbert, Ian H., Read, Kevin D., Wyatt, Paul G., Baragana, Beatriz
Published in Journal of medicinal chemistry (23.11.2023)
Published in Journal of medicinal chemistry (23.11.2023)
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Journal Article
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
Milne, Rachel, Wiedemar, Natalie, Corpas-Lopez, Victoriano, Moynihan, Eoin, Wall, Richard J., Dawson, Alice, Robinson, David A., Shepherd, Sharon M., Smith, Robert J., Hallyburton, Irene, Post, John M., Dowers, Karen, Torrie, Leah S., Gilbert, Ian H., Baragaña, Beatriz, Patterson, Stephen, Wyllie, Susan
Published in ACS infectious diseases (09.09.2022)
Published in ACS infectious diseases (09.09.2022)
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Journal Article
Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022
Caldwell, Nicola, Afshar, Rana, Baragaña, Beatriz, Bustinduy, Amaya L., Caffrey, Conor R., Collins, James J., Fusco, Daniela, Garba, Amadou, Gardner, Mark, Gomes, Mireille, Hoffmann, Karl F., Hsieh, Michael, Lo, Nathan C., McNamara, Case W., Nono, Justin Komguep, Padalino, Gilda, Read, Kevin D., Roestenberg, Meta, Spangenberg, Thomas, Specht, Sabine, Gilbert, Ian H.
Published in ACS infectious diseases (12.05.2023)
Published in ACS infectious diseases (12.05.2023)
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Journal Article
Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity
Pérez-Moreno, Guiomar, Sánchez-Carrasco, Paula, Ruiz-Pérez, Luis Miguel, Johansson, Nils Gunnar, Müller, Sylke, Baragaña, Beatriz, Hampton, Shahienaz Emma, Gilbert, Ian Hugh, Kaiser, Marcel, Sarkar, Sandipan, Pandurangan, Thiyagamurthy, Kumar, Vijeesh, González-Pacanowska, Dolores
Published in Malaria journal (03.12.2019)
Published in Malaria journal (03.12.2019)
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Journal Article
Screening a protein kinase inhibitor library against Plasmodium falciparum
Hallyburton, Irene, Grimaldi, Raffaella, Woodland, Andrew, Baragaña, Beatriz, Luksch, Torsten, Spinks, Daniel, James, Daniel, Leroy, Didier, Waterson, David, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H, Frearson, Julie A
Published in Malaria journal (07.11.2017)
Published in Malaria journal (07.11.2017)
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Journal Article
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
Hewitt, Stephen Nakazawa, Dranow, David M, Horst, Benjamin G, Abendroth, Jan A, Forte, Barbara, Hallyburton, Irene, Jansen, Chimed, Baragaña, Beatriz, Choi, Ryan, Rivas, Kasey L, Hulverson, Matthew A, Dumais, Mitchell, Edwards, Thomas E, Lorimer, Donald D, Fairlamb, Alan H, Gray, David W, Read, Kevin D, Lehane, Adele M, Kirk, Kiaran, Myler, Peter J, Wernimont, Amy, Walpole, Chris, Stacy, Robin, Barrett, Lynn K, Gilbert, Ian H, Van Voorhis, Wesley C
Published in ACS infectious diseases (13.01.2017)
Published in ACS infectious diseases (13.01.2017)
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Journal Article
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
Norcross, Neil R., Wilson, Caroline, Baragaña, Beatriz, Hallyburton, Irene, Osuna‐Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Fletcher, Daniel, Sinden, Robert, Delves, Michael, Ruecker, Andrea, Duffy, Sandra, Meister, Stephan, Antonova‐Koch, Yevgeniya, Crespo, Benigno, de Cózar, Cristina, Sanz, Laura M., Gamo, Francisco Javier, Avery, Vicky M., Frearson, Julie A., Gray, David W., Fairlamb, Alan H., Winzeler, Elizabeth A., Waterson, David, Campbell, Simon F., Willis, Paul A., Read, Kevin D., Gilbert, Ian H.
Published in ChemMedChem (17.07.2019)
Published in ChemMedChem (17.07.2019)
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Journal Article
Protease-Catalyzed Peptide Synthesis on Solid Support
Ulijn, Rein V, Baragaña, Beatriz, Halling, Peter J, Flitsch, Sabine L
Published in Journal of the American Chemical Society (18.09.2002)
Published in Journal of the American Chemical Society (18.09.2002)
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Journal Article
β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase
Baragaña, Beatriz, McCarthy, Orla, Sánchez, Paula, Bosch-Navarrete, Cristina, Kaiser, Marcel, Brun, Reto, Whittingham, Jean L., Roberts, Shirley M., Zhou, Xiao-Xiong, Wilson, Keith S., Johansson, Nils Gunnar, González-Pacanowska, Dolores, Gilbert, Ian H.
Published in Bioorganic & medicinal chemistry (01.04.2011)
Published in Bioorganic & medicinal chemistry (01.04.2011)
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Journal Article
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif
Klee, Nina, Wong, Pui Ee, Baragaña, Beatriz, Mazouni, Farah El, Phillips, Margaret A., Barrett, Michael P., Gilbert, Ian H.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Design, Synthesis, and Evaluation of 5′-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase
Hampton, Shahienaz E., Baragaña, Beatriz, Schipani, Alessandro, Bosch-Navarrete, Cristina, Musso-Buendía, J. Alexander, Recio, Eliseo, Kaiser, Marcel, Whittingham, Jean L., Roberts, Shirley M., Shevtsov, Mikhail, Brannigan, James A., Kahnberg, Pia, Brun, Reto, Wilson, Keith S., González-Pacanowska, Dolores, Johansson, Nils Gunnar, Gilbert, Ian H.
Published in ChemMedChem (04.10.2011)
Published in ChemMedChem (04.10.2011)
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Journal Article
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
Summers, Robert L., Pasaje, Charisse Flerida A., Pisco, Joao P., Striepen, Josefine, Luth, Madeline R., Kumpornsin, Krittikorn, Carpenter, Emma F., Munro, Justin T., Lin, De, Plater, Andrew, Punekar, Avinash S., Shepherd, Andrew M., Shepherd, Sharon M., Vanaerschot, Manu, Murithi, James M., Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A. Hazel, Won, Madalyn, Mandt, Rebecca E.K., McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus C.S., Winzeler, Elizabeth A., Fidock, David A., Gilbert, Ian H., Wirth, Dyann F., Niles, Jacquin C., Baragaña, Beatriz, Lukens, Amanda K.
Published in Cell chemical biology (17.02.2022)
Published in Cell chemical biology (17.02.2022)
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Journal Article
Design of the Global Health chemical diversity library v2 for screening against infectious diseases
Wilson, Caroline, Gardner, J Mark F, Gray, David W, Baragana, Beatriz, Wyatt, Paul G, Cookson, Alex, Thompson, Stephen, Mendoza-Martinez, Cesar, Bodkin, Michael J, Gilbert, Ian H, Tarver, Gary J
Published in PLoS neglected tropical diseases (01.12.2023)
Published in PLoS neglected tropical diseases (01.12.2023)
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Journal Article
Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
Norcross, Neil R, Baragaña, Beatriz, Wilson, Caroline, Hallyburton, Irene, Osuna-Cabello, Maria, Norval, Suzanne, Riley, Jennifer, Stojanovski, Laste, Simeons, Frederick R. C, Porzelle, Achim, Grimaldi, Raffaella, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M, Meister, Stephan, Sanz, Laura, Jiménez-Díaz, Belén, Angulo-Barturen, Iñigo, Ferrer, Santiago, Martínez, María Santos, Gamo, Francisco Javier, Frearson, Julie A, Gray, David W, Fairlamb, Alan H, Winzeler, Elizabeth A, Waterson, David, Campbell, Simon F, Willis, Paul, Read, Kevin D, Gilbert, Ian H
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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