First in human study with GSK3359609 [GSK609], inducible T cell co-stimulator (ICOS) receptor agonist in patients [Pts] with advanced, solid tumors: Preliminary results from INDUCE-1
Hansen, A., Bauer, T.M., Moreno, V., Maio, M., Groenland, S., Martin-Liberal, J., Gan, H., Rischin, D., Millward, M., Olszanski, A.J., Cho, D.C., Paul, E., Ballas, M., Ellis, C., Zhou, H., Yadavilli, S., Sadik Shaik, J., Schmidt, E.V., Hoos, A., Angevin, E.
Published in Annals of oncology (01.10.2018)
Published in Annals of oncology (01.10.2018)
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Journal Article
Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor
Ishii, Hidehiro, Jirousek, Michael R., Koya, Daisuke, Takagi, Chikako, Xia, Pu, Clermont, Allen, Bursell, Sven-Erik, Kern, Timothy S., Ballas, Lawrence M., Heath, William F., Stramm, Lawrence E., Feener, Edward P., King, George L.
Published in Science (American Association for the Advancement of Science) (03.05.1996)
Published in Science (American Association for the Advancement of Science) (03.05.1996)
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Journal Article
Estrogen Receptor (ER) Modulators Each Induce Distinct Conformational Changes in ER α and ER β
Paige, Lisa A., Christensen, Dale J., Grøn, Hanne, Norris, John D., Gottlin, Elizabeth B., Padilla, Karen M., Chang, Ching-yi, Ballas, Lawrence M., Hamilton, Paul T., McDonnell, Donald P., Fowlkes, Dana M.
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.1999)
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Journal Article
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3
Toker, A, Meyer, M, Reddy, K K, Falck, J R, Aneja, R, Aneja, S, Parra, A, Burns, D J, Ballas, L M, Cantley, L C
Published in The Journal of biological chemistry (23.12.1994)
Published in The Journal of biological chemistry (23.12.1994)
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Journal Article
(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ
Jirousek, Michael R, Gillig, James R, Gonzalez, Cecile M, Heath, William F, McDonald, John H, Neel, David A, Rito, Christopher J, Singh, Upinder, Stramm, Lawrence E, Melikian-Badalian, Anita, Baevsky, Matthew, Ballas, Lawrence M, Hall, Steven E, Winneroski, Leonard L, Faul, Margaret M
Published in Journal of medicinal chemistry (05.07.1996)
Published in Journal of medicinal chemistry (05.07.1996)
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Journal Article
Anti-AIDS Agents, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzigium claviflorum, and the Anti-HIV Activity of Structurally Related Triterpenoids
Fujioka, Toshihiro, Kashiwada, Yoshiki, Kilkuskie, Robert E, Cosentino, L. Mark, Ballas, Lawrence M, Jiang, Jack B, Janzen, William P, Chen, Ih-Sheng, Lee, Kuo-Hsiung
Published in Journal of natural products (Washington, D.C.) (01.02.1994)
Published in Journal of natural products (Washington, D.C.) (01.02.1994)
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Journal Article
Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ
Faul, Margaret M, Gillig, James R, Jirousek, Michael R, Ballas, Lawrence M, Schotten, Theo, Kahl, Astrid, Mohr, Michael
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
Published in Bioorganic & medicinal chemistry letters (02.06.2003)
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Journal Article
Balanol: a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides
Kulanthaivel, Palaniappan, Hallock, Yali F, Boros, Christie, Hamilton, Sean M, Janzen, William P, Ballas, Lawrence M, Loomis, Carson R, Jiang, Jack B, Katz, Barry
Published in Journal of the American Chemical Society (01.07.1993)
Published in Journal of the American Chemical Society (01.07.1993)
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Journal Article
Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway
Kunisaki, M, Bursell, S E, Clermont, A C, Ishii, H, Ballas, L M, Jirousek, M R, Umeda, F, Nawata, H, King, G L
Published in The American journal of physiology (01.08.1995)
Published in The American journal of physiology (01.08.1995)
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Journal Article
Synthesis and Protein Kinase Inhibitory Activity of Balanol Analogues with Modified Benzophenone Subunits
Lampe, John W, Biggers, Christopher K, Defauw, Jean M, Foglesong, Robert J, Hall, Steven E, Heerding, Julia M, Hollinshead, Sean P, Hu, Hong, Hughes, Philip F, Jagdmann, G. Erik, Johnson, Mary George, Lai, Yen-Shi, Lowden, Christopher T, Lynch, Michael P, Mendoza, José S, Murphy, Marcia M, Wilson, Joseph W, Ballas, Lawrence M, Carter, Kiyomi, Darges, James W, Davis, Jefferson E, Hubbard, Frederick R, Stamper, Mark L
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Journal Article
1189TiP Phase II study of anti-TIGIT GSK4428859A (GSK’859A)/EOS-448 + anti-CD96 GSK6097608 (GSK’608) + anti-PD-1 dostarlimab in non-small cell lung cancer (NSCLC)
Spigel, D.R., Garrido Lopez, P., Cousin, S., Cheema, P.K., Rodríguez, L.M., Garassino, M.C., Kijewska, M., Majumdar, A., Theti, D.S., Roy-Ghanta, S., Ballas, M., Reck, M.
Published in Annals of oncology (01.09.2022)
Published in Annals of oncology (01.09.2022)
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Journal Article
951P The relationship between overall survival (OS), progression-free survival (PFS), and objective response rate (ORR) in immune checkpoint inhibitor clinical trials of head and neck squamous cell carcinoma (HNSCC): A systematic review and meta-analysis
Wang, X., Ballas, M., Chen, H., Bell, K.F., Slowley, A., Ellis, C., Baccan, C., Turner, D.C., Zhou, H.
Published in Annals of oncology (01.09.2020)
Published in Annals of oncology (01.09.2020)
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Journal Article
Synthesis and Protein Kinase C Inhibitory Activities of Balanol Analogs with Replacement of the Perhydroazepine Moiety
Lai, Yen-Shi, Mendoza, José S, Jagdmann, G. Erik, Menaldino, David S, Biggers, Christopher K, Heerding, Julia M, Wilson, Joseph W, Hall, Steven E, Jiang, Jack B, Janzen, William P, Ballas, Lawrence M
Published in Journal of medicinal chemistry (17.01.1997)
Published in Journal of medicinal chemistry (17.01.1997)
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Journal Article
EP08.01-020 Phase 2 Platform Trial of Anti-TIGIT GSK’859A/EOS-448 + Anti-PD-1 Dostarlimab in Non-small Cell Lung Cancer (NSCLC)
Spigel, D., Lopez, P.G., Cheema, P., Garassino, M., Cousin, S., Gandhi, Y., Theti, D., Stylianou, A., Messina, C., Roy-Ghanta, S., Ballas, M., Reck, M.
Published in Journal of thoracic oncology (01.09.2022)
Published in Journal of thoracic oncology (01.09.2022)
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Journal Article
New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C
Kashiwada, Yoshiki, Huang, Li, Ballas, Lawrence M, Jiang, Jack B, Janzen, William P, Lee, K.-H
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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Journal Article
A Phase 2, Non-Comparative, Open-Label, International Study of MEDI4736 in Patients with Locally Advanced or Metastatic PD-L1-Positive NSCLC (Stage IIIB-IV) Who have Received ≥ 2 Prior Systemic Treatment Regimens (Atlantic)
Rizvi, N., Ballas, M., Jayawardene, D., Stockman, P.K., Powderly, J.D.
Published in Annals of oncology (01.11.2014)
Published in Annals of oncology (01.11.2014)
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