Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models
Daniels, Michael J D, Rivers-Auty, Jack, Schilling, Tom, Spencer, Nicholas G, Watremez, William, Fasolino, Victoria, Booth, Sophie J, White, Claire S, Baldwin, Alex G, Freeman, Sally, Wong, Raymond, Latta, Clare, Yu, Shi, Jackson, Joshua, Fischer, Nicolas, Koziel, Violette, Pillot, Thierry, Bagnall, James, Allan, Stuart M, Paszek, Pawel, Galea, James, Harte, Michael K, Eder, Claudia, Lawrence, Catherine B, Brough, David
Published in Nature communications (11.08.2016)
Published in Nature communications (11.08.2016)
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Inhibiting the Inflammasome: A Chemical Perspective
Baldwin, Alex G, Brough, David, Freeman, Sally
Published in Journal of medicinal chemistry (10.03.2016)
Published in Journal of medicinal chemistry (10.03.2016)
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Boron-Based Inhibitors of the NLRP3 Inflammasome
Baldwin, Alex G., Rivers-Auty, Jack, Daniels, Michael J.D., White, Claire S., Schwalbe, Carl H., Schilling, Tom, Hammadi, Halah, Jaiyong, Panichakorn, Spencer, Nicholas G., England, Hazel, Luheshi, Nadia M., Kadirvel, Manikandan, Lawrence, Catherine B., Rothwell, Nancy J., Harte, Michael K., Bryce, Richard A., Allan, Stuart M., Eder, Claudia, Freeman, Sally, Brough, David
Published in Cell chemical biology (16.11.2017)
Published in Cell chemical biology (16.11.2017)
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Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity
Collins, Ross, Lee, Hyunah, Jones, D. Heulyn, Elkins, Jonathan M., Gillespie, Jason A., Thomas, Carys, Baldwin, Alex G., Jones, Kimberley, Waters, Loren, Paine, Marie, Atack, John R., Ward, Simon E., Grubisha, Olivera, Foley, David W.
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses
Redondo-Castro, Elena, Faust, Dorte, Fox, Simon, Baldwin, Alex G, Osborne, Simon, Haley, Michael J, Karran, Eric, Nuthall, Hugh, Atkinson, Peter J, Dawson, Lee A, Routledge, Carol, Allan, Stuart M, Freeman, Sally, Brownlees, Janet, Brough, David
Published in Scientific reports (04.04.2018)
Published in Scientific reports (04.04.2018)
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Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome
Baldwin, Alex G., Tapia, Victor S., Swanton, Tessa, White, Claire S., Beswick, James A., Brough, David, Freeman, Sally
Published in ChemMedChem (20.02.2018)
Published in ChemMedChem (20.02.2018)
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Evaluation of analogues of furan-amidines as inhibitors of NQO2
Alnabulsi, Soraya, Hussein, Buthaina, Santina, Elham, Alsalahat, Izzeddin, Kadirvel, Manikandan, Magwaza, Rachael N., Bryce, Richard A., Schwalbe, Carl H., Baldwin, Alex G., Russo, Ilaria, Stratford, Ian J., Freeman, Sally
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
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