Discovery of N‑(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)‑5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)‑2H‑tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis
Ruminski, Peter G, Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E, Schmidt, Michelle, Scholten, Jeffrey A, Fletcher, Theresa R, Hamper, Bruce C, Carroll, Jeffery N, Shieh, Huey S, Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E, Collins, Joe, Baldus, John E, Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D, McDonald, Joseph, Munie, Grace E, Messing, Dean M, Portolan, Silvia, Whiteley, Laurence O, Sunyer, Teresa, Schnute, Mark E
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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Journal Article
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition
Jerome, Kevin D., Rucker, Paul V., Xing, Li, Shieh, Huey S., Baldus, John E., Selness, Shaun R., Letavic, Michael A., Braganza, John F., McClure, Kim F.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Discovery of 5-substituted- N-arylpyridazinones as inhibitors of p38 MAP kinase
Jerome, Kevin D., Hepperle, Michael E., Walker, John K., Xing, Li, Devraj, Rajesh V., Benson, Alan G., Baldus, John E., Selness, Shaun R.
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Discovery of N -(4-Fluoro-3-methoxybenzyl)-6-(2-(((2 S ,5 R )-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2 H -tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis
Ruminski, Peter G., Massa, Mark, Strohbach, Joseph, Hanau, Cathleen E., Schmidt, Michelle, Scholten, Jeffrey A., Fletcher, Theresa R., Hamper, Bruce C., Carroll, Jeffery N., Shieh, Huey S., Caspers, Nicole, Collins, Brandon, Grapperhaus, Margaret, Palmquist, Katherine E., Collins, Joe, Baldus, John E., Hitchcock, Jeffrey, Kleine, H. Peter, Rogers, Michael D., McDonald, Joseph, Munie, Grace E., Messing, Dean M., Portolan, Silvia, Whiteley, Laurence O., Sunyer, Teresa, Schnute, Mark E.
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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Journal Article
Novel Triazolopyridine Compounds for the Treatment of Inflammation
BALDUS JOHN E, SELNESS SHAUN R, JEROME KEVIN D, RUCKER PAUL V, XING LI
Year of Publication 27.08.2009
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Year of Publication 27.08.2009
Patent
Novel Triazolopyridine Compounds
BALDUS JOHN E, SELNESS SHAUN R, JEROME KEVIN D, RUCKER PAUL V, XING LI
Year of Publication 20.08.2009
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Year of Publication 20.08.2009
Patent
Process for making substituted pyrazoles
DAN R. DUKESHERER, WIN NAING, LISA L MCDERMOTT, SHEKHAR VISWANATH, JERRY D CLARK, PATRICK H LAU, JOHN E BALDUS, JODI L MOE, SHAUN R SELNESS, MICHAEL K. MAO, JOHN K WALKER, KIMBERLEY C ALLEN, ALBERT D EDNEY, DENNIS K ANDERSON, CHRISTINE B SEYMOUR, PARTHA S MUDIPALLI
Year of Publication 08.11.2007
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Year of Publication 08.11.2007
Patent
PROCESS FOR MAKING SUBSTITUTED PYRAZOLE
NAING WIN, EDNEY ALBERT D, MOE JODI L, SEYMOUR CHRISTINE B, SELNESS SHAUN D, YALAMANCHILI GOPICHAND, FEVIG TOM, VISWANATH SHEKHAR, ALLEN KIMBERLEY C, BOEHLOW TODD, DUKESHERER DANIEL R, WALKER JOHN K, CLARK JERRY D, MCDERMOTT LISA L, KUNDA SASTRY, MUDIPALLI PARTHA, SCHILKE TOBIN C, LAU PATRICK H, MAO MICHAEL K, BALDUS JOHN E, ANDERSON DENNIS K, LAWSON JON P
Year of Publication 20.09.2007
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Year of Publication 20.09.2007
Patent
Process for making substituted pyrazoles
SELNESS, SHAUN R, BOEHLOW, TODD, NAING, WIN, FEVIG, TOM, LAWSON, JON P, DUKESHERER, DANIEL R, MUDIPALLI, PARTHA, ALLEN, KIMBERLEY C, VISWANATH, SHEKHAR, MCDERMOTT, LISA L, BALDUS, JOHN E, SCHILKE, TOBIN C, SEYMOUR, CHRISTINE B, CLARK, JERRY D, LAU, PATRICK H, MOE, JODI L, YALAMANCHILI, GOPICHANDWALKER, JOHN K, ANDERSON, DENNIS K, EDENY, ALBERT D, KUNDA, SASTRY, MAO, MICHAEL K
Year of Publication 28.03.2007
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Year of Publication 28.03.2007
Patent
Substituierte Pyrazole als P38-kinaseinhibitoren
NAING, WIN, LIAO, SHUYUAN, YU, YI, WEIER, RICHARD M, CRICH, JOYCE Z, VAZQUEZ, MICHAEL L, HEPPERLE, MICHAEL, FLYNN, DANIEL L, HARTMANN, SUSAN J, HANAU, CATHLEEN E, COLLINS, PAUL W, XU, XIANGDONG, WALKER, JOHN K, YANG, SYAULAN, STEALEY, MICHAEL A, HUANG, HE, JEROME, KEVIN D, SELNESS, SHAUN RAJ, SOUTH, MICHAEL S, GENG, LIFENG, PERRY, THAO D, KHANNA, ISH K, TALLEY, JOHN JEFFREY, CLARE, MICHAEL, METZ, SUZANNE, BALDUS, JOHN E, PARTIS, RICHARD A, DEVRAJ, RAJESH, KOSZYK, FRANCIS J, ANANTANARAYAN, ASHOK, HANSON, GUNNAR J, RAO, SHASHIDHAR N, GRANETO, MATTHEW J
Year of Publication 21.05.2008
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Year of Publication 21.05.2008
Patent
Process for making substituted pyrazoles
Allen, Kimberley C, Anderson, Dennis K, Baldus, John E, Boehlow, Todd, Clark, Jerry D, Dukesherer, Dan R, Edney, Albert D, Fevig, Tom, Kunda, Sastry, Lawson, Jon P, Lau, Patrick H, McDermott, Lisa L, Mao, Michael K, Moe, Jodi L, Mudipalli, Partha, Naing, Win, Selness, Shaun R, Seymour, Christine B, Schilke, Tobin C, Viswanath, Shekhar, Walker, John K, Yalamanchili, Gopichand
Year of Publication 06.06.2006
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Year of Publication 06.06.2006
Patent
Process for making substituted pyrazoles
NAING WIN, EDNEY ALBERT D, MOE JODI L, SEYMOUR CHRISTINE B, DUKESHERER DAN R, SELNESS SHAUN R, YALAMANCHILI GOPICHAND, FEVIG TOM, VISWANATH SHEKHAR, ALLEN KIMBERLEY C, BOEHLOW TODD, WALKER JOHN K, CLARK JERRY D, MCDERMOTT LISA L, KUNDA SASTRY, MUDIPALLI PARTHA, SCHILKE TOBIN C, LAU PATRICK H, MAO MICHAEL K, BALDUS JOHN E, ANDERSON DENNIS K, LAWSON JON P
Year of Publication 06.06.2006
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Year of Publication 06.06.2006
Patent
PROCESS FOR MAKING SUBSTITUTED PYRAZOLES
BOEHLOW, TODD, NAING, WIN, FEVIG, TOM, MUDIPALLI, PARTHA, ALLEN, KIMBERLEY C, SELNESS, SHAUN, D, CLARK, JERRY, D, MAO, MICHAEL, K, LAWSON, JON, P, EDNEY, ALBERT, D, DUKESHERER, DANIEL, R, MCDERMOTT, LISA, L, BALDUS, JOHN, E, SEYMOUR, CHRISTINE, B, WALKER, JOHN, K, SCHILKE, TOBIN, C, LAU, PATRICK, H, ANDERSON, DENNIS, K, MOE, JODI, L, KUNDA, SASTRY
Year of Publication 11.01.2006
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Year of Publication 11.01.2006
Patent
SUBSTITUIERTE PYRAZOLE ALS P38-KINASEINHIBITOREN
NAING, WIN, LIAO, SHUYUAN, YU, YI, WEIER, RICHARD M, CRICH, JOYCE Z, VAZQUEZ, MICHAEL L, HEPPERLE, MICHAEL, FLYNN, DANIEL L, HARTMANN, SUSAN J, HANAU, CATHLEEN E, COLLINS, PAUL W, XU, XIANGDONG, WALKER, JOHN K, YANG, SYAULAN, STEALEY, MICHAEL A, HUANG, HE, JEROME, KEVIN D, SELNESS, SHAUN RAJ, SOUTH, MICHAEL S, GENG, LIFENG, PERRY, THAO D, KHANNA, ISH K, TALLEY, JOHN JEFFREY, CLARE, MICHAEL, METZ, SUZANNE, BALDUS, JOHN E, PARTIS, RICHARD A, DEVRAJ, RAJESH, KOSZYK, FRANCIS J, ANANTANARAYAN, ASHOK, HANSON, GUNNAR J, RAO, SHASHIDHAR N, GRANETO, MATTHEW J
Year of Publication 15.10.2007
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Year of Publication 15.10.2007
Patent
PROCESS FOR MAKING SUBSTITUTED PYRAZOLES
NAING WIN, EDNEY ALBERT D, MOE JODI L, SEYMOUR CHRISTINE B, SELNESS SHAUN R, YALAMANCHILI GOPICHAND, FEVIG TOM, VISWANATH SHEKHAR, ALLEN KIMBERLEY C, BOEHLOW TODD, DUKESHERER DANIEL R, WALKER JOHN K, CLARK JERRY D, MCDERMOTT LISA L, KUNDA SASTRY, MUDIPALLI PARTHA, SCHILKE TOBIN C, LAU PATRICK H, MAO MICHAEL K, BALDUS JOHN E, ANDERSON DENNIS K, LAWSON JON P
Year of Publication 09.11.2005
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Year of Publication 09.11.2005
Patent
Process for making substituted pyrazoles
WIN NAING, SHEKHAR VISWANATH, ALLEN, KIMBERLY, K, CLARK, JERRY, D, MAO, MICHAEL, K, DUKESHERER, DAN, R, EDNEY, ALBERT, D, MCDERMOTT, LISA, L, BALDUS, JOHN, E, MUDIPALLI, PARTHAN, S, SEYMOUR, CHRISTINE, B, WALKER, JOHN, K, SCHILKE, TOBIN, C, GOPI YALAMANCHILI, LAU, PATRICK, H, ANDERSON, DENNIS, K, MOE, JODI, L, SELNESS, SHAUN, R
Year of Publication 27.05.2005
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Year of Publication 27.05.2005
Patent
Process for making substituted pyrazoles
Allen, Kimberly K, Anderson, Dennis K, Baldus, John E, Clark, Jerry D, Edeny, Albert D, Lau, Patrick H, Dukesherer, Daniel R, McDermott, Lisa, Mao, Michael K, Yalamanchili, Gopi, Moe, Jodi L, Mudipalli, Partha, Naing, Win, Selness, Shaun R, Seymour, Christine, Viswanath, Shekhar, Walker, John K
Year of Publication 24.05.2005
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Year of Publication 24.05.2005
Patent
Process for making substituted pyrazoles
NAING WIN, SEYMOUR CHRISTINE, MOE JODI L, MCDERMOTT LISA, SELNESS SHAUN R, VISWANATH SHEKHAR, DUKESHERER DANIEL R, WALKER JOHN K, CLARK JERRY D, EDENY ALBERT D, MUDIPALLI PARTHA, ALLEN KIMBERLY K, LAU PATRICK H, MAO MICHAEL K, YALAMANCHILI GOPI, BALDUS JOHN E, ANDERSON DENNIS K
Year of Publication 24.05.2005
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Year of Publication 24.05.2005
Patent
PROCESS FOR MAKING SUBSTITUTED PYRAZOLES
NAING, WIN, ALLEN, KIMBERLY, K, CLARK, JERRY, D, VISWANATH, SHEKHAR, MUDIPALLI, PARTHA, S, MCDERMOTT, LISA, L, BALDUS, JOHN, E, SEYMOUR, CHRISTINE, B, WALKER, JOHN, K, EDENY, ALBERT, D, LAU, PATRICK, H, ANDERSON, DENNIS, K, MOE, JODI, L, SELNESS, SHAUN, R
Year of Publication 03.04.2003
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Year of Publication 03.04.2003
Patent