Identification and Characterization of Compounds That Potentiate NT-3-Mediated Trk Receptor Activity
Lewis, Martin A, Hunihan, Lisa, Franco, Diana, Robertson, Barbara, Palmer, Jane, Laurent, Denis R St, Balasubramanian, Balu N, Li, Yi, Westphal, Ryan S
Published in Molecular pharmacology (01.04.2006)
Published in Molecular pharmacology (01.04.2006)
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Journal Article
Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11
Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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Journal Article
Sordaricin antifungal agents
Quesnelle, Claude A, Gill, Patrice, Dodier, Marco, St. Laurent, Denis, Serrano-Wu, Michael, Marinier, Anne, Martel, Alain, Mazzucco, Charles E, Stickle, Terry M, Barrett, John F, Vyas, Dolatrai M, Balasubramanian, Balu N
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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Journal Article
Novel fluoro-substituted camptothecins : in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization
ROSE, William C, MARATHE, Punit H, JANG, Graham R, MONTICELLO, Thomas M, BALASUBRAMANIAN, Balu N, LONG, Byron, FAIRCHILD, Craig R, WALL, Monroe E, WANI, Mansukh C
Published in Cancer chemotherapy and pharmacology (01.07.2006)
Published in Cancer chemotherapy and pharmacology (01.07.2006)
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Journal Article
Sordarin Oxazepine Derivatives as Potent Antifungal Agents
Serrano-Wu, Michael H., St. Laurent, Denis R., Chen, Yijun, Huang, Stella, Lam, Kin-Ray, Matson, James A., Mazzucco, Charles E., Stickle, Terry M., Tully, Thomas P., Wong, Henry S., Vyas, Dolatrai M., Balasubramanian, Balu N.
Published in Bioorganic & medicinal chemistry letters (07.10.2002)
Published in Bioorganic & medicinal chemistry letters (07.10.2002)
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Journal Article
Identification of a broad-Spectrum azasordarin with improved pharmacokinetic properties
Serrano-Wu, Michael H., Laurent, Denis R.St, Carroll, Tina M., Dodier, Marco, Gao, Qi, Gill, Patrice, Quesnelle, Claude, Marinier, Anne, Mazzucco, Charles E., Regueiro-Ren, Alicia, Stickle, Terry M., Wu, Dedong, Yang, Hyekyung, Yang, Zheng, Zheng, Ming, Zoeckler, Mary E., Vyas, Dolatrai M., Balasubramanian, Balu N.
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
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Journal Article
Core-modified sordaricin derivatives: Synthesis and antifungal activity
Regueiro-Ren, Alicia, Carroll, Tina M., Chen, Yijun, Matson, James A., Huang, Stella, Mazzucco, Charles E., Stickle, Terry M., Vyas, Dolatrai M., Balasubramanian, Balu N.
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
Published in Bioorganic & medicinal chemistry letters (02.12.2002)
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Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Wright, John J, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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Journal Article
Mild deprotection of 2-(trimethylsilyl)ethyl esters
Serrano-Wu, Michael H, Regueiro-Ren, Alicia, St. Laurent, Denis R, Carroll, Tina M, Balasubramanian, Balu N
Published in Tetrahedron letters (03.12.2001)
Published in Tetrahedron letters (03.12.2001)
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Journal Article
A practical synthesis of aryl tetrafluoroethyl ethers via the improved reaction of phenols with 1,2-dibromotetrafluoroethane
Li, Jianqing, Qiao, Jennifer X., Smith, Daniel, Chen, Bang-Chi, Salvati, Mark E., Roberge, Jacques Y., Balasubramanian, Balu N.
Published in Tetrahedron letters (15.10.2007)
Published in Tetrahedron letters (15.10.2007)
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Journal Article
Preparation of Monofluorophenols via the Reaction of Difluorobenzene Derivatives with Potassium Trimethylsilanoate
Li, Jianqing, Smith, Daniel, Qiao, Jennifer X., Huang, Stella, Krishnananthan, Subramaniam, Wong, Henry S., Salvati, Mark E., Balasubramanian, Balu N., Chen, Bang-Chi
Published in Synlett (01.03.2009)
Published in Synlett (01.03.2009)
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Journal Article
Novel 3 ',6 '-anhydro and N12,N13-bridged glycosylated fluoroindolo[2,3-a]carbazoles as topoisomerase I inhibitors. Fluorine as a leaving group from sp(3) carbon
Saulnier, MG, Langley, DR, Frennesson, DB, Long, BH, Huang, S, Gao, Q, Wu, DD, Fairchild, CR, Ruediger, E, Zimmermann, K, St Laurent, DR, Balasubramanian, BN, Vyas, DM
Published in Organic letters (31.03.2005)
Published in Organic letters (31.03.2005)
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Journal Article
Novel 3‘,6‘-Anhydro and N12,N13-Bridged Glycosylated Fluoroindolo[2,3-a]carbazoles as Topoisomerase I Inhibitors. Fluorine as a Leaving Group from sp3 Carbon
Saulnier, Mark G, Langley, David R, Frennesson, David B, Long, Byron H, Huang, Stella, Gao, Qi, Wu, Dedong, Fairchild, Craig R, Ruediger, Edward, Zimmermann, Kurt, St. Laurent, Denis R, Balasubramanian, Balu N, Vyas, Dolatrai M
Published in Organic letters (31.03.2005)
Published in Organic letters (31.03.2005)
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Journal Article
Novel 3‘,6‘-Anhydro and N12,N13-Bridged Glycosylated Fluoroindolo[2,3- a ]carbazoles as Topoisomerase I Inhibitors. Fluorine as a Leaving Group from sp 3 Carbon
Saulnier, Mark G., Langley, David R., Frennesson, David B., Long, Byron H., Huang, Stella, Gao, Qi, Wu, Dedong, Fairchild, Craig R., Ruediger, Edward, Zimmermann, Kurt, St. Laurent, Denis R., Balasubramanian, Balu N., Vyas, Dolatrai M.
Published in Organic letters (01.03.2005)
Published in Organic letters (01.03.2005)
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Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole-5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesson, David B., Kramer, Robert, Lee, Frank Y., Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C., Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M., Wong, Henry, Wright, John J., Zimmermann, Kurt, Vyas, Dolatrai M.
Published in Journal of medicinal chemistry (01.01.2005)
Published in Journal of medicinal chemistry (01.01.2005)
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Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]- thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole- 5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesson, David B., Kramer, Robert, Lee, Frank Y., Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C., Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M., Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M.
Published in Journal of medicinal chemistry (01.03.2004)
Published in Journal of medicinal chemistry (01.03.2004)
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Journal Article
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H, 13H-benzo[b]-thien yl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model
BALASUBRAMANIAN, Balu N, LAURENT, Denis R. St, FRENNESSON, David B, KRAMER, Robert, LEE, Frank Y, MAHLER, Mikael, MARTEL, Alain, NAIDU, B. Narasimhulu, ROSE, William C, RUSSELL, John, RUEDIGER, Edward, SOLOMON, Carola, SAULNIER, Mark G, STOFFAN, Karen M, WONG, Henry, ZIMMERMANN, Kurt, VYAS, Dolatrai M, LONG, Byron H, BACHAND, Carol, BEAULIEU, Francis, CLARKE, Wendy, DESHPANDE, Milind, EUMMER, Jeffrey, FAIRCHILD, Craig R
Published in Journal of medicinal chemistry (2004)
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Published in Journal of medicinal chemistry (2004)
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