MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport
George, Richard T., Abuhatzira, Liron, Stoughton, Susan M., Karathanasis, Sotirios K., She, Dewei, Jin, ChaoYu, Buss, Nicholas A. P. S., Bakker‐Arkema, Rebecca, Ongstad, Emily L., Koren, Michael, Hirshberg, Boaz
Published in Journal of the American Heart Association (06.07.2021)
Published in Journal of the American Heart Association (06.07.2021)
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Journal Article
Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner
Pedro-Botet, Juan, Schaefer, Ernst J., Bakker-Arkema, Rebecca G., Black, Donald M., Stein, Evan M., Corella, Dolores, Ordovas, Jose M.
Published in Atherosclerosis (01.09.2001)
Published in Atherosclerosis (01.09.2001)
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Journal Article
Safety and Tolerability of ACP-501, a Recombinant Human Lecithin: Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation Study
Shamburek, Robert D, Bakker-Arkema, Rebecca, Shamburek, Alexandra M, Freeman, Lita A, Amar, Marcelo J, Auerbach, Bruce, Krause, Brian R, Homan, Reynold, Adelman, Steve J, Collins, Heidi L, Sampson, Maureen, Wolska, Anna, Remaley, Alan T
Published in Circulation research (08.01.2016)
Published in Circulation research (08.01.2016)
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Journal Article
Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement
Shamburek, Robert D., MD, Bakker-Arkema, Rebecca, PharmD, Auerbach, Bruce J., PhD, Krause, Brian R., PhD, Homan, Reynold, PhD, Amar, Marcelo J., MD, Freeman, Lita A., PhD, Remaley, Alan T., MD, PhD
Published in Journal of clinical lipidology (01.03.2016)
Published in Journal of clinical lipidology (01.03.2016)
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Journal Article
Efficacy and Safety of Gemcabene as Add-on to Stable Statin Therapy in Patients with Hypercholesterolemia
Koren, Michael, MD, Bays, Harold, MD, Stein, Evan, MD, Bakker-Arkema, Rebecca, RPh, MS, Bisgaier, Charles, PhD
Published in Journal of clinical lipidology (01.05.2016)
Published in Journal of clinical lipidology (01.05.2016)
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Journal Article
Treating patients with documented atherosclerosis to national cholesterol education program-recommended low-density-lipoprotein cholesterol goals with atorvastatin, fluvastatin, lovastatin and simvastatin
Brown, Alan S, Bakker-Arkema, Rebecca G, Yellen, Laurence, Henley, Robert W, Guthrie, Richard, Campbell, Cam F, Koren, Michael, Woo, William, McLain, Richard, Black, Donald M
Published in Journal of the American College of Cardiology (01.09.1998)
Published in Journal of the American College of Cardiology (01.09.1998)
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Journal Article
EFFECT OF GEMCABENE ON INSULIN SENSITIVITY IN NONDIABETIC, OBESE SUBJECTS
Bakker-Arkema, Rebecca, Bisgaier, Charles
Published in Journal of the American College of Cardiology (21.03.2017)
Published in Journal of the American College of Cardiology (21.03.2017)
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Journal Article
Model-based development of gemcabene, a new lipid-altering agent
Mandema, Jaap W., Hermann, David, Wang, Wenping, Sheiner, Tim, Milad, Mark, Bakker-Arkema, Rebecca, Hartman, Daniel
Published in The AAPS journal (01.09.2005)
Published in The AAPS journal (01.09.2005)
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Journal Article
Safety profile of atorvastatin-treated patients with low LDL-cholesterol levels
Bakker-Arkema, Rebecca G, Nawrocki, James W, Black, Donald M
Published in Atherosclerosis (01.03.2000)
Published in Atherosclerosis (01.03.2000)
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Journal Article
Conference Proceeding
Usefulness of Gemcabene in Homozygous Familial Hypercholesterolemia (from COBALT-1)
Gaudet, Daniel, Durst, Ronen, Lepor, Norman, Bakker-Arkema, Rebecca, Bisgaier, Charles, Masson, Liz, Golden, Lee, Kastelein, John J., Hegele, Robert A., Stein, Evan
Published in The American journal of cardiology (15.12.2019)
Published in The American journal of cardiology (15.12.2019)
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Journal Article
The cost of reaching National Cholesterol Education Program (NCEP) goals in hypercholesterolaemic patients. A comparison of atorvastatin, simvastatin, lovastatin and fluvastatin
Koren, M J, Smith, D G, Hunninghake, D B, Davidson, M H, McKenney, J M, Weiss, S R, Schrott, H G, Henley, Jr, R W, Tresh, P, McLain, R W, Bakker-Arkema, R G, Black, D M
Published in PharmacoEconomics (01.07.1998)
Published in PharmacoEconomics (01.07.1998)
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Journal Article
Abstract 23082: Gemcabene Add-On Therapy to High- and Moderate-Intensity Statin Stratums in Hypercholesterolemic Subjects (ROYAL-1, a Phase 2b Study)
Frias, Juan, Kastelein, John, Bakker-Arkema, Rebecca, Masson, Liz, Golden, Lee, Bisgaier, Charles, Stein, Evan
Published in Circulation (New York, N.Y.) (14.11.2017)
Published in Circulation (New York, N.Y.) (14.11.2017)
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Journal Article
A brief review paper of the efficacy and safety of atorvastatin in early clinical trials
Bakker-Arkema, Rebecca G, Best, James, Fayyad, Rana, Heinonen, Therese M, Marais, A.David, Nawrocki, James W, Black, Donald M
Published in Atherosclerosis (01.05.1997)
Published in Atherosclerosis (01.05.1997)
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Book Review
Journal Article
2214-PUB: An Open-Label Study of Gemcabene in Adults with Familial Partial Lipodystrophy
AKINCI, BARIS, SWAIDAN, MARIO, FOSS-FREITAS, MARIA CRISTINA, LUO, YINGYING, NEIDERT, ADAM H., HENCH, RITA P., CHENEVERT, THOMAS L., LONGCORE, AMY, BAKKER-ARKEMA, REBECCA, BISGAIER, CHARLES L., ORAL, ELIF A.
Published in Diabetes (New York, N.Y.) (01.06.2020)
Published in Diabetes (New York, N.Y.) (01.06.2020)
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Journal Article
Abstract 18673: Human Enzyme Replacement Therapy in a Patient With Familial Lecithin Cholesterol Acyltransferase Deficiency: Rapid Appearance of Normal Appearing HDL
Shamburek, Robert D, Freeman, Lita, Sampson, Maureen, Bakker-Arkema, Rebecca, Krause, Brian, Auerbach, Bruce, Homan, Ryan, Shamburek, Alexandra, Schwartz, Charles, Amar, Marcelo, Remaley, Alan
Published in Circulation (New York, N.Y.) (26.11.2013)
Published in Circulation (New York, N.Y.) (26.11.2013)
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Journal Article
Efficacy and safety of a new HMG-CoA reductase inhibitor, atorvastatin, in patients with hypertriglyceridemia
Bakker-Arkema, R G, Davidson, M H, Goldstein, R J, Davignon, J, Isaacsohn, J L, Weiss, S R, Keilson, L M, Brown, W V, Miller, V T, Shurzinske, L J, Black, D M
Published in JAMA : the journal of the American Medical Association (10.01.1996)
Published in JAMA : the journal of the American Medical Association (10.01.1996)
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Journal Article
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution
Pfefferkorn, Jeffrey A., Litchfield, John, Hutchings, Richard, Cheng, Xue-Min, Larsen, Scott D., Auerbach, Bruce, Bush, Mark R., Lee, Chitase, Erasga, Noe, Bowles, Daniel M., Boyles, David C., Lu, Gina, Sekerke, Catherine, Askew, Valerie, Hanselman, Jeffrey C., Dillon, Lisa, Lin, Zhiwu, Robertson, Andrew, Olsen, Karl, Boustany, Carine, Atkinson, Karen, Goosen, Theunis C., Sahasrabudhe, Vaishali, Chupka, Jonathan, Duignan, David B., Feng, Bo, Scialis, Renato, Kimoto, Emi, Bi, Yi-An, Lai, Yurong, El-Kattan, Ayman, Bakker-Arkema, Rebecca, Barclay, Paul, Kindt, Erick, Le, Vu, Mandema, Jaap W., Milad, Mark, Tait, Bradley D., Kennedy, Robert, Trivedi, Bharat K., Kowala, Mark
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
Lipid and apolipoprotein levels and distribution in patients with hypertriglyceridemia: Effect of triglyceride reductions with atorvastatin
Le, Ngoc-Anh, Innis-Whitehouse, Wendy, Li, Xianzhou, Bakker-Arkema, Rebecca, Black, Donald, Brown, W. Virgil
Published in Metabolism, clinical and experimental (01.02.2000)
Published in Metabolism, clinical and experimental (01.02.2000)
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