Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, Bennett G, Durik, Matej, Baker, Darren J, van Deursen, Jan M
Published in Nature medicine (01.12.2015)
Published in Nature medicine (01.12.2015)
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Journal Article
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, Bennett G, Baker, Darren J, Wijshake, Tobias, Conover, Cheryl A, Campisi, Judith, van Deursen, Jan M
Published in Science (American Association for the Advancement of Science) (28.10.2016)
Published in Science (American Association for the Advancement of Science) (28.10.2016)
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Journal Article
Senescence and apoptosis: dueling or complementary cell fates?
Childs, Bennett G, Baker, Darren J, Kirkland, James L, Campisi, Judith, van Deursen, Jan M
Published in EMBO reports (01.11.2014)
Published in EMBO reports (01.11.2014)
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Journal Article
Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown
Yamazaki, Yu, Baker, Darren J, Tachibana, Masaya, Liu, Chia-Chen, van Deursen, Jan M, Brott, Thomas G, Bu, Guojun, Kanekiyo, Takahisa
Published in Stroke (1970) (01.04.2016)
Published in Stroke (1970) (01.04.2016)
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Journal Article
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Schafer, Marissa J, White, Thomas A, Evans, Glenda, Tonne, Jason M, Verzosa, Grace C, Stout, Michael B, Mazula, Daniel L, Palmer, Allyson K, Baker, Darren J, Jensen, Michael D, Torbenson, Michael S, Miller, Jordan D, Ikeda, Yasuhiro, Tchkonia, Tamara, van Deursen, Jan M, Kirkland, James L, LeBrasseur, Nathan K
Published in Diabetes (New York, N.Y.) (01.06.2016)
Published in Diabetes (New York, N.Y.) (01.06.2016)
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Journal Article
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
North, Brian J, Rosenberg, Michael A, Jeganathan, Karthik B, Hafner, Angela V, Michan, Shaday, Dai, Jing, Baker, Darren J, Cen, Yana, Wu, Lindsay E, Sauve, Anthony A, van Deursen, Jan M, Rosenzweig, Anthony, Sinclair, David A
Published in The EMBO journal (01.07.2014)
Published in The EMBO journal (01.07.2014)
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Journal Article
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
Baker, Darren J., Dawlaty, Meelad M., Wijshake, Tobias, Jeganathan, Karthik B., Malureanu, Liviu, van Ree, Janine H., Crespo-Diaz, Ruben, Reyes, Santiago, Seaburg, Lauren, Shapiro, Virginia, Behfar, Atta, Terzic, Andre, van de Sluis, Bart, van Deursen, Jan M.
Published in Nature cell biology (01.01.2013)
Published in Nature cell biology (01.01.2013)
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Journal Article
p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
Baker, Darren J., Weaver, Robbyn L., van Deursen, Jan M.
Published in Cell reports (Cambridge) (25.04.2013)
Published in Cell reports (Cambridge) (25.04.2013)
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Journal Article
ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis
Li, Min, Fang, Xiao, Baker, Darren J, Guo, Linjie, Gao, Xue, Wei, Zhubo, Han, Shuhua, van Deursen, Jan M, Zhang, Pumin
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2010)
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Journal Article
Spartan deficiency causes genomic instability and progeroid phenotypes
Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.
Published in Nature communications (11.12.2014)
Published in Nature communications (11.12.2014)
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Journal Article
Hyperphosphorylated PTEN exerts oncogenic properties
van Ree, Janine H., Jeganathan, Karthik B., Fierro Velasco, Raul O., Zhang, Cheng, Can, Ismail, Hamada, Masakazu, Li, Hu, Baker, Darren J., van Deursen, Jan M.
Published in Nature communications (24.05.2023)
Published in Nature communications (24.05.2023)
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Journal Article
p21 induces a senescence program and skeletal muscle dysfunction
Englund, Davis A., Jolliffe, Alyssa, Aversa, Zaira, Zhang, Xu, Sturmlechner, Ines, Sakamoto, Ayumi E., Zeidler, Julianna D., Warner, Gina M., McNinch, Colton, White, Thomas A., Chini, Eduardo N., Baker, Darren J., van Deursen, Jan M., LeBrasseur, Nathan K.
Published in Molecular metabolism (Germany) (01.01.2023)
Published in Molecular metabolism (Germany) (01.01.2023)
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Journal Article
BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome
Sieben, Cynthia J, Jeganathan, Karthik B, Nelson, Grace G, Sturmlechner, Ines, Zhang, Cheng, van Deursen, Willemijn H, Bakker, Bjorn, Foijer, Floris, Li, Hu, Baker, Darren J, van Deursen, Jan M
Published in The Journal of clinical investigation (01.01.2020)
Published in The Journal of clinical investigation (01.01.2020)
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