Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression
Bailey-Downs, Lora C, Thorpe, Jessica E, Disch, Bryan C, Bastian, Anja, Hauser, Paul J, Farasyn, Taleah, Berry, William L, Hurst, Robert E, Ihnat, Michael A
Published in PloS one (30.05.2014)
Published in PloS one (30.05.2014)
Get full text
Journal Article
17α‐estradiol acts through hypothalamic pro‐opiomelanocortin expressing neurons to reduce feeding behavior
Steyn, Frederik J., Ngo, Shyuan T., Chen, Vicky Ping, Bailey‐Downs, Lora C., Xie, Teresa Y., Ghadami, Martin, Brimijoin, Stephen, Freeman, Willard M., Rubinstein, Marcelo, Low, Malcolm J., Stout, Michael B.
Published in Aging cell (01.02.2018)
Published in Aging cell (01.02.2018)
Get full text
Journal Article
Selenium Deficiency Exacerbates Hyperoxia-Induced Lung Injury in Newborn C3H/HeN Mice
Bailey-Downs, Lora C, Sherlock, Laura G, Crossley, Michaela N, Rivera Negron, Aristides, Pierce, Paul T, Wang, Shirley, Zhong, Hua, Carter, Cynthia, Burge, Kathryn, Eckert, Jeffrey V, Rogers, Lynette K, Vitiello, Peter F, Tipple, Trent E
Published in Antioxidants (01.04.2024)
Published in Antioxidants (01.04.2024)
Get full text
Journal Article
Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation
Bailey-Downs, Lora C, Tucsek, Zsuzsanna, Toth, Peter, Sosnowska, Danuta, Gautam, Tripti, Sonntag, William E, Csiszar, Anna, Ungvari, Zoltan
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.07.2013)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.07.2013)
Get more information
Journal Article
Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging
Bailey-Downs, Lora C, Mitschelen, Matthew, Sosnowska, Danuta, Toth, Peter, Pinto, John T, Ballabh, Praveen, Valcarcel-Ares, M Noa, Farley, Julie, Koller, Akos, Henthorn, Jim C, Bass, Caroline, Sonntag, William E, Ungvari, Zoltan, Csiszar, Anna
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.04.2012)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.04.2012)
Get more information
Journal Article
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
Zhang, Xin, Raghavan, Sudhir, Ihnat, Michael, Thorpe, Jessica E., Disch, Bryan C., Bastian, Anja, Bailey-Downs, Lora C., Dybdal-Hargreaves, Nicholas F., Rohena, Cristina C., Hamel, Ernest, Mooberry, Susan L., Gangjee, Aleem
Published in Bioorganic & medicinal chemistry (15.07.2014)
Published in Bioorganic & medicinal chemistry (15.07.2014)
Get full text
Journal Article
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer
Bastian, Anja, Thorpe, Jessica E, Disch, Bryan C, Bailey-Downs, Lora C, Gangjee, Aleem, Devambatla, Ravi K V, Henthorn, Jim, Humphries, Kenneth M, Vadvalkar, Shraddha S, Ihnat, Michael A
Published in The Journal of pharmacology and experimental therapeutics (01.05.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2015)
Get full text
Journal Article
Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging
Bailey-Downs, Lora C, Sosnowska, Danuta, Toth, Peter, Mitschelen, Matthew, Gautam, Tripti, Henthorn, Jim C, Ballabh, Praveen, Koller, Akos, Farley, Julie A, Sonntag, William E, Csiszar, Anna, Ungvari, Zoltan
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.06.2012)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.06.2012)
Get more information
Journal Article
Discovery of Antitubulin Agents with Antiangiogenic Activity as Single Entities with Multitarget Chemotherapy Potential
Gangjee, Aleem, Pavana, Roheeth Kumar, Ihnat, Michael A, Thorpe, Jessica E, Disch, Bryan C, Bastian, Anja, Bailey-Downs, Lora C, Hamel, Ernest, Bai, Rouli
Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
Get full text
Journal Article
Identification of novel drugs to target dormant micrometastases
Hurst, Robert E, Hauser, Paul J, You, Youngjae, Bailey-Downs, Lora C, Bastian, Anja, Matthews, Stephen M, Thorpe, Jessica, Earle, Christine, Bourguignon, Lilly Y W, Ihnat, Michael A
Published in BMC cancer (14.05.2015)
Published in BMC cancer (14.05.2015)
Get full text
Journal Article
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents
Gangjee, Aleem, Zhao, Ying, Ihnat, Michael A., Thorpe, Jessica E., Bailey-Downs, Lora C., Kisliuk, Roy L.
Published in Bioorganic & medicinal chemistry (15.07.2012)
Published in Bioorganic & medicinal chemistry (15.07.2012)
Get full text
Journal Article
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents
Gangjee, Aleem, Namjoshi, Ojas A., Yu, Jianming, Ihnat, Michael A., Thorpe, Jessica E., Bailey-Downs, Lora C.
Published in Bioorganic & medicinal chemistry (01.03.2013)
Published in Bioorganic & medicinal chemistry (01.03.2013)
Get full text
Journal Article
Abstract 3776: Mechanistic evaluation of AG311 - an OXPHOS inhibitor - as a potential treatment for breast cancer
Bastian, Anja, Matsuzaki, Satoshi, Humphries, Kenneth M., Bailey-Downs, Lora C., Gangjee, Aleem, Ihnat, Michael A.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression
Mitschelen, M, Yan, H, Farley, J.A, Warrington, J.P, Han, S, Hereñú, C.B, Csiszar, A, Ungvari, Z, Bailey-Downs, L.C, Bass, C.E, Sonntag, W.E
Published in Neuroscience (30.06.2011)
Published in Neuroscience (30.06.2011)
Get full text
Journal Article
N-2-Trimethylacetyl substituted and unsubstituted-N-4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents
Gangjee, Aleem, Namjoshi, Ojas A., Yu, Jianming, Ihnat, Michael A., Thorpe, Jessica E., Bailey-Downs, Lora C.
Published in Bioorganic & medicinal chemistry (01.03.2013)
Published in Bioorganic & medicinal chemistry (01.03.2013)
Get full text
Journal Article
17[alpha]-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
Steyn, Frederik J, Ngo, Shyuan T, Chen, Vicky Ping, Bailey-Downs, Lora C, Xie, Teresa Y, Ghadami, Martin, Brimijoin, Stephen, Freeman, Willard M, Rubinstein, Marcelo, Low, Malcolm J, Stout, Michael B
Published in Aging cell (01.02.2018)
Published in Aging cell (01.02.2018)
Get full text
Journal Article
Abstract 4451: Novel small molecule AG311 induces tumor cell death through inhibition of mitochondrial electron transport
Bastian, Anja, Bailey-Downs, Lora C., Thorpe, Jessica E., Devambatla, Ravi Kumar Vyas, Gangjee, Aleem, Humphries, Kenneth M., Ihnat, Michael A.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 1389: Development and characterization of a natural model of triple negative breast micrometastasis
Ihnat, Michael A., Bailey-Downs, Lora C., Thorpe, Jessica E., Disch, Bryan C., Bastian, Anja, Farasyn, Taleah C., Hauser, Paul J., Hurst, Robert E.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article