Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Journal Article
Structure-based optimization of aminothiadiazole inhibitors of AKT
Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Journal Article
Fluorination-Free Synthesis of a 4,4-Difluoro-3,3-Dimethylproline Derivative
Chen, Lijian, Kim, Young Mi, Kucera, David J, Harrison, Katheryn E, Bahmanyar, Sogole, Scott, Jill M, Yazbeck, Daniel
Published in Journal of organic chemistry (21.07.2006)
Published in Journal of organic chemistry (21.07.2006)
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Journal Article
Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001
Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen
Riggs, Jennifer R, Nagy, Mark, Elsner, Jan, Erdman, Paul, Cashion, Dan, Robinson, Dale, Harris, Roy, Huang, Dehua, Tehrani, Lida, Deyanat-Yazdi, Gordafaried, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Barnes, Leo, Miller, Terra, Katz, Jason, Tang, Yang, Chen, Ming, Moghaddam, Mehran F, Bahmanyar, Sogole, Pagarigan, Barbra, Delker, Silvia, LeBrun, Laurie, Chamberlain, Philip P, Calabrese, Andrew, Canan, Stacie S, Leftheris, Katerina, Zhu, Dan, Boylan, John F
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
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Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity
Elsner, Jan, Cashion, Dan, Robinson, Dale, Bahmanyar, Sogole, Tehrani, Lida, Fultz, Kimberly E, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Apuy, Julius, LeBrun, Laurie, Leftheris, Katerina, Boylan, John F, Zhu, Dan, Riggs, Jennifer R
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Journal Article
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy
Riggs, Jennifer R, Elsner, Jan, Cashion, Dan, Robinson, Dale, Tehrani, Lida, Nagy, Mark, Fultz, Kimberly E, Krishna Narla, Rama, Peng, Xiaohui, Tran, Tam, Kulkarni, Ashutosh, Bahmanyar, Sogole, Condroski, Kevin, Pagarigan, Barbra, Fenalti, Gustavo, LeBrun, Laurie, Leftheris, Katerina, Zhu, Dan, Boylan, John F
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Discovery of the Selective Protein Kinase C-theta Kinase Inhibitor, CC-90005
Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S., Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E.
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor
Plantevin Krenitsky, Véronique, Nadolny, Lisa, Delgado, Mercedes, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Hegde, Sayee, D’Sidocky, Neil, Sapienza, John, Wright, Jonathan, McCarrick, Meg, Bahmanyar, Sogole, Chamberlain, Philip, Delker, Silvia L., Muir, Jeff, Giegel, David, Xu, Li, Celeridad, Maria, Lachowitzer, Jeff, Bennett, Brydon, Moghaddam, Mehran, Khatsenko, Oleg, Katz, Jason, Fan, Rachel, Bai, April, Tang, Yang, Shirley, Michael A., Benish, Brent, Bodine, Tracey, Blease, Kate, Raymon, Heather, Cathers, Brian E., Satoh, Yoshitaka
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Journal Article
Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223
Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Journal Article
Abstract 1180: Discovery of CC-91516, a potent and selective ERK/NLK inhibitor, with anti-tumor activity in preclinical cancer models harboring BRAF or CTNNB1 mutation
Xu, Shuichan, Tran, Tam, Zhu, Dan, Shi, Tao, Mikolon, David, Leisten, Jim, Chamberlain, Philip, LeBrun, Laurie, Bahmanyar, Sogole, Jiang, Ning, Zhao, Jingjing, Malek, Mehnaz, Filvaroff, Ellen, Raymon, Heather, Hubbard, Robert, Boylan, John
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Substituted Aminopurine Compounds Compositions Thereof and Methods of Treatment Therewith
ZHAO JINGJING, BOYLAN JOHN FREDRERICK, MOGHADDAM MEHRAN, SCHWARZ KIMBERLY, TRAN TAM MINH, XU SHUICHAN, ALEXANDER MATTHEW, RAHEJA RAJ K, RAYMON HEATHER, HANSEN JOSHUA, BAHMANYAR SOGOLE, HUBBARD ROBERT, LEISTEN JIM, TORRES EDUARDO, JEFFY BRANDON, HUANG DEHUA, SLOSS MARIANNE
Year of Publication 13.03.2023
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Year of Publication 13.03.2023
Patent
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury
Krenitsky, Véronique Plantevin, Delgado, Mercedes, Nadolny, Lisa, Sahasrabudhe, Kiran, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Kois, Adam, Hughes, Kevin, Wright, Jonathan, Nowakowski, Jacek, Sudbeck, Elise, Ghosh, Sutapa, Bahmanyar, Sogole, Chamberlain, Philip, Muir, Jeff, Cathers, Brian E., Giegel, David, Xu, Li, Celeridad, Maria, Moghaddam, Mehran, Khatsenko, Oleg, Omholt, Paul, Katz, Jason, Pai, Sema, Fan, Rachel, Tang, Yang, Shirley, Michael A., Benish, Brent, Blease, Kate, Raymon, Heather, Bhagwat, Shripad, Henderson, Ian, Cole, Andrew G., Bennett, Brydon, Satoh, Yoshitaka
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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치환된 3-피페리딘-2,6-디온 화합물, 이의 조성물, 및 이를 사용한 치료 방법
NARLA RAMA KRISHNA, XU SHUICHAN, HORN EVAN J, PLANTEVIN KRENITSKY VERONIQUE, MAYNE CHRISTOPHER, NORRIS STEPHEN, CORREA MATTHEW D, WHITEFIELD BRANDON W, AMMIRANTE MASSIMO, GRANT VIRGINIA, KERCHER TIMOTHY S, HANSEN JOSHUA, BAHMANYAR SOGOLE, SAPIENZA JOHN J, PAPA PATRICK, NAYAK SURENDRA, NAGY MARK A
Year of Publication 01.10.2021
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Year of Publication 01.10.2021
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Substituted Aminopurine Compounds Compositions Thereof and Methods of Treatment Therewith
ZHAO JINGJING, BOYLAN JOHN FREDRERICK, MOGHADDAM MEHRAN, SCHWARZ KIMBERLY, TRAN TAM MINH, XU SHUICHAN, ALEXANDER MATTHEW, RAHEJA RAJ K, RAYMON HEATHER, HANSEN JOSHUA, BAHMANYAR SOGOLE, HUBBARD ROBERT, LEISTEN JIM, TORRES EDUARDO, JEFFY BRANDON, HUANG DEHUA, SLOSS MARIANNE
Year of Publication 08.06.2017
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Year of Publication 08.06.2017
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SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
HEGDE SAYEE, RAHEJA RAJ, PLANTEVIN KRENITSKY VERONIQUE, NORRIS STEPHEN, CALABRESE ANDREW ANTONY, SAPIENZA JOHN, LEFTHERIS KATERINA, HANSEN JOSHUA, CORREA MATTHEW, BAHMANYAR SOGOLE, CATHERS BRIAN EDWIN, TORRES EDUARDO, PAPA PATRICK, MORTENSEN DEBORAH, PARNES JASON, WHITEFIELD BRANDON WADE, BENNETT BRYDON, HUANG DEHUA, CASHION DANIEL, DELGADO MARIA MERCEDES
Year of Publication 10.08.2016
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Year of Publication 10.08.2016
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Crystal Structures of Orotidine Monophosphate Decarboxylase: Does the Structure Reveal the Mechanism of Nature's Most Proficient Enzyme?
Houk, Kendall N., Lee, Jeehiun K., Tantillo, Dean J., Bahmanyar, Sogole, Hietbrink, Bruce N.
Published in Chembiochem : a European journal of chemical biology (02.02.2001)
Published in Chembiochem : a European journal of chemical biology (02.02.2001)
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AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS
ZHAO JINGJING, FAHR BRUCE, STEVENS RANDALL, DELGADO MERCEDES, PLANTEVIN KRENITSKY VERONIQUE, NADOLNY LISA, SAPIENZA JOHN, BAHMANYAR SOGOLE, BLEASE KATE, WHITEFIELD BRANDON WADE, ERDMAN PAUL, WALLACE ANDREW, LEE BRANDEN, SANKAR SABITA, PACKARD GARRICK, SLOAN VICTOR, CALABRESE ANDREW ANTONY, SATOH YOSHITAKA, DANIEL THOMAS ORAN, FERGUSON GREGORY, RIGGS JENNIFER, ROHANE PATRICIA, TORRES EDUARDO, PAPA PATRICK, ELSNER JAN, BATES R.J, TEHRANI LIDA, TIKHE JAYASHREE
Year of Publication 19.05.2011
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Year of Publication 19.05.2011
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SYNTHETIC INTERMEDIATES USEFUL FOR PREPARING SUBSTITUTED AMINOPURINE COMPOUNDS
TORRES, Eduardo, BOYLAN, John Frederick, Schwarz, Kimberly, TRAN, Tam Minh, HUBBARD, Robert, HANSEN, Joshua, BAHMANYAR, Sogole, XU, Shuichan, RAHEJA, Raj Kumar, HUANG, Dehua, JEFFY, Brandon David, SLOSS, Marianne, ALEXANDER, Matthew, LEISTEN, Jim, ZHAO, Jingjing, MOGHADDAM, Mehran, RAYMON, Heather
Year of Publication 06.03.2024
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Year of Publication 06.03.2024
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