Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Sotillo, Elena, Barrett, David M, Black, Kathryn L, Bagashev, Asen, Oldridge, Derek, Wu, Glendon, Sussman, Robyn, Lanauze, Claudia, Ruella, Marco, Gazzara, Matthew R, Martinez, Nicole M, Harrington, Colleen T, Chung, Elaine Y, Perazzelli, Jessica, Hofmann, Ted J, Maude, Shannon L, Raman, Pichai, Barrera, Alejandro, Gill, Saar, Lacey, Simon F, Melenhorst, Jan J, Allman, David, Jacoby, Elad, Fry, Terry, Mackall, Crystal, Barash, Yoseph, Lynch, Kristen W, Maris, John M, Grupp, Stephan A, Thomas-Tikhonenko, Andrei
Published in Cancer discovery (01.12.2015)
Published in Cancer discovery (01.12.2015)
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Journal Article
Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19
Asnani, Mukta, Hayer, Katharina E., Naqvi, Ammar S., Zheng, Sisi, Yang, Scarlett Y., Oldridge, Derek, Ibrahim, Fadia, Maragkakis, Manolis, Gazzara, Matthew R., Black, Kathryn L., Bagashev, Asen, Taylor, Deanne, Mourelatos, Zissimos, Grupp, Stephan A., Barrett, David, Maris, John M., Sotillo, Elena, Barash, Yoseph, Thomas-Tikhonenko, Andrei
Published in Leukemia (01.04.2020)
Published in Leukemia (01.04.2020)
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Journal Article
Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia
Loftus, Joseph P, Yahiaoui, Anella, Brown, Patrick A, Niswander, Lisa M, Bagashev, Asen, Wang, Min, Schauf, Allyson, Tannheimer, Stacey, Tasian, Sarah K
Published in Haematologica (Roma) (01.04.2021)
Published in Haematologica (Roma) (01.04.2021)
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Journal Article
Aberrant splicing in B-cell acute lymphoblastic leukemia
Black, Kathryn L, Naqvi, Ammar S, Asnani, Mukta, Hayer, Katharina E, Yang, Scarlett Y, Gillespie, Elisabeth, Bagashev, Asen, Pillai, Vinodh, Tasian, Sarah K, Gazzara, Matthew R, Carroll, Martin, Taylor, Deanne, Lynch, Kristen W, Barash, Yoseph, Thomas-Tikhonenko, Andrei
Published in Nucleic acids research (30.11.2018)
Published in Nucleic acids research (30.11.2018)
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Journal Article
CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy
Pillai, Vinodh, Muralidharan, Kavitha, Meng, Wenzhao, Bagashev, Asen, Oldridge, Derek A., Rosenthal, Jaclyn, Van Arnam, John, Melenhorst, Jos J., Mohan, Diwakar, DiNofia, Amanda M., Luo, Minjie, Cherian, Sindhu, Fromm, Jonathan R., Wertheim, Gerald, Thomas-Tikhonenko, Andrei, Paessler, Michele, June, Carl H., Luning Prak, Eline T., Bhoj, Vijay G., Grupp, Stephan A., Maude, Shannon L., Rheingold, Susan R.
Published in Blood advances (26.11.2019)
Published in Blood advances (26.11.2019)
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Journal Article
Role of p53 in Neurodegenerative Diseases
Chang, J. Robert, Ghafouri, Mohammad, Mukerjee, Ruma, Bagashev, Asen, Chabrashvili, Tinatin, Sawaya, Bassel E.
Published in Neuro-degenerative diseases (01.01.2012)
Published in Neuro-degenerative diseases (01.01.2012)
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Journal Article
Noncoding RNAs and LRRFIP1 regulate TNF expression
Shi, Lihua, Song, Li, Fitzgerald, Michael, Maurer, Kelly, Bagashev, Asen, Sullivan, Kathleen E
Published in The Journal of immunology (1950) (01.04.2014)
Published in The Journal of immunology (1950) (01.04.2014)
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Journal Article
Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies
Zheng, Sisi, Gillespie, Elisabeth, Naqvi, Ammar S, Hayer, Katharina E, Ang, Zhiwei, Torres-Diz, Manuel, Quesnel-Vallières, Mathieu, Hottman, David A, Bagashev, Asen, Chukinas, John, Schmidt, Carolin, Asnani, Mukta, Shraim, Rawan, Taylor, Deanne M, Rheingold, Susan R, O'Brien, Maureen M, Singh, Nathan, Lynch, Kristen W, Ruella, Marco, Barash, Yoseph, Tasian, Sarah K, Thomas-Tikhonenko, Andrei
Published in Blood cancer discovery (01.03.2022)
Published in Blood cancer discovery (01.03.2022)
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Journal Article
Immune dysregulation in severe influenza
Heltzer, Meredith L., Coffin, Susan E., Maurer, Kelly, Bagashev, Asen, Zhang, Zhe, Orange, Jordan S., Sullivan, Kathleen E.
Published in Journal of leukocyte biology (01.06.2009)
Published in Journal of leukocyte biology (01.06.2009)
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Journal Article
HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein
Shrestha, Jenny, Santerre, Maryline, Allen, Charles N S, Arjona, Sterling P, Merali, Carmen, Mukerjee, Ruma, Chitrala, Kumaraswamy Naidu, Park, Jin, Bagashev, Asen, Bui, Viet, Eugenin, Eliseo A, Merali, Salim, Kaul, Marcus, Chin, Jeannie, Sawaya, Bassel E
Published in Frontiers in aging neuroscience (09.05.2022)
Published in Frontiers in aging neuroscience (09.05.2022)
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Journal Article
1514 In vivo CAR-M: redirecting endogenous myeloid cells with mRNA for cancer immunotherapy
Varghese, Bindu, Mori, Simone, Pierini, Stefano, Bagashev, Asen, Ohtani, Yumi, Gabbasov, Rashid, Ross, Kayleigh, Huang, Shuo, Bona, Amanda, Merdiana, Sherly, Slovik, Kate, Worth, Alison, Nagar, Karan, Saporito, Robert, Shaw, Lauren, Ball, Michael, Qureshi, Rehman, Minutolo, Nicholas, Tosh, Kevin, Lee, Claudia, Lukacs, Christine, Guey, Lin, Klichinsky, Michael, Condamine, Thomas
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Multi-Modal Targeting of FLT3 with Chimeric Antigen Receptor T Cell Immunotherapy and Tyrosine Kinase Inhibition in High-Risk Pediatric Leukemias
Niswander, Lisa M, Graff, Zachary, Bagashev, Asen, Leach, Lillie, Fry, Terry J., Tasian, Sarah K
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Precision Co-Targeting of the Thymic Stromal Lymphopoietin Receptor in Childhood CRLF2-Rearranged Acute Lymphoblastic Leukemia
Bagashev, Asen, Loftus, Joseph Patrick, Ross, Savannah, Niswander, Lisa M, Qin, Haiying, Fry, Terry J., Tasian, Sarah K
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum
Bagashev, Asen, Sotillo, Elena, Tang, Chih-Hang Anthony, Black, Kathryn L., Perazzelli, Jessica, Seeholzer, Steven H., Argon, Yair, Barrett, David M., Grupp, Stephan A., Hu, Chih-Chi Andrew, Thomas-Tikhonenko, Andrei
Published in Molecular and cellular biology (01.11.2018)
Published in Molecular and cellular biology (01.11.2018)
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Journal Article
Alisertib Synergistically Strengthens the Anti-Leukemia Activity of Venetoclax in TCF3-Hlf B-ALL
Bagashev, Asen, Loftus, Joseph Patrick, Wakefield, Colin, Wertheim, Gerald, Hurtz, Christian, Carroll, Martin P., Stegmaier, Kimberly, Pikman, Yana, Tasian, Sarah K
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL
Hurtz, Christian, Wertheim, Gerald B, Loftus, Joseph P, Blumenthal, Daniel, Lehman, Anne, Li, Yong, Bagashev, Asen, Manning, Bryan, Cummins, Katherine D, Burkhardt, Janis K, Perl, Alexander E, Carroll, Martin, Tasian, Sarah K
Published in The Journal of clinical investigation (01.07.2020)
Published in The Journal of clinical investigation (01.07.2020)
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Journal Article
HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3)
Santerre, Maryline, Bagashev, Asen, Gorecki, Laura, Lysek, Kyle Z., Wang, Ying, Shrestha, Jenny, Del Carpio-Cano, Fabiola, Mukerjee, Ruma, Sawaya, Bassel E.
Published in The Journal of biological chemistry (08.03.2019)
Published in The Journal of biological chemistry (08.03.2019)
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Journal Article