Cysteine depletion induces pancreatic tumor ferroptosis in mice
Badgley, Michael A, Kremer, Daniel M, Maurer, H Carlo, DelGiorno, Kathleen E, Lee, Ho-Joon, Purohit, Vinee, Sagalovskiy, Irina R, Ma, Alice, Kapilian, Jonathan, Firl, Christina E M, Decker, Amanda R, Sastra, Steve A, Palermo, Carmine F, Andrade, Leonardo R, Sajjakulnukit, Peter, Zhang, Li, Tolstyka, Zachary P, Hirschhorn, Tal, Lamb, Candice, Liu, Tong, Gu, Wei, Seeley, E Scott, Stone, Everett, Georgiou, George, Manor, Uri, Iuga, Alina, Wahl, Geoffrey M, Stockwell, Brent R, Lyssiotis, Costas A, Olive, Kenneth P
Published in Science (American Association for the Advancement of Science) (03.04.2020)
Published in Science (American Association for the Advancement of Science) (03.04.2020)
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Multivalent Small-Molecule Pan-RAS Inhibitors
Welsch, Matthew E., Kaplan, Anna, Chambers, Jennifer M., Stokes, Michael E., Bos, Pieter H., Zask, Arie, Zhang, Yan, Sanchez-Martin, Marta, Badgley, Michael A., Huang, Christine S., Tran, Timothy H., Akkiraju, Hemanth, Brown, Lewis M., Nandakumar, Renu, Cremers, Serge, Yang, Wan Seok, Tong, Liang, Olive, Kenneth P., Ferrando, Adolfo, Stockwell, Brent R.
Published in Cell (23.02.2017)
Published in Cell (23.02.2017)
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GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
Kremer, Daniel M., Nelson, Barbara S., Lin, Lin, Yarosz, Emily L., Halbrook, Christopher J., Kerk, Samuel A., Sajjakulnukit, Peter, Myers, Amy, Thurston, Galloway, Hou, Sean W., Carpenter, Eileen S., Andren, Anthony C., Nwosu, Zeribe C., Cusmano, Nicholas, Wisner, Stephanie, Mbah, Nneka E., Shan, Mengrou, Das, Nupur K., Magnuson, Brian, Little, Andrew C., Savani, Milan R., Ramos, Johanna, Gao, Tina, Sastra, Stephen A., Palermo, Carmine F., Badgley, Michael A., Zhang, Li, Asara, John M., McBrayer, Samuel K., di Magliano, Marina Pasca, Crawford, Howard C., Shah, Yatrik M., Olive, Kenneth P., Lyssiotis, Costas A.
Published in Nature communications (11.08.2021)
Published in Nature communications (11.08.2021)
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Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, Olive, Kenneth P.
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia
Garcia-Bermudez, Javier, Badgley, Michael A, Prasad, Sheela, Baudrier, Lou, Liu, Yuyang, La, Konnor, Soula, Mariluz, Williams, Robert T, Yamaguchi, Norihiro, Hwang, Rosa F, Taylor, Laura J, de Stanchina, Elisa, Rostandy, Bety, Alwaseem, Hanan, Molina, Henrik, Bar-Sagi, Dafna, Birsoy, Kıvanç
Published in Nature metabolism (01.06.2022)
Published in Nature metabolism (01.06.2022)
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"Tumor-selective treatment of metastatic pancreatic cancer with an engineered, probiotic living drug"
Decker-Farrell, Amanda R, Sastra, Stephen A, Harimoto, Tetsuhiro, Hasselluhn, Marie C, Palermo, Carmine F, Ballister, Edward R, Badgley, Michael A, Danino, Tal, Olive, Kenneth P
Published in bioRxiv : the preprint server for biology (05.05.2024)
Published in bioRxiv : the preprint server for biology (05.05.2024)
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Journal Article
Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer
Maurer, H Carlo, Garcia-Curiel, Alvaro, Holmstrom, Sam R, Castillo, Cristina, Palermo, Carmine F, Sastra, Steven A, Andren, Anthony, Zhang, Li, Le Large, Tessa Y S, Sagalovskiy, Irina, Ross, Daniel R, Wong, Winston, Shaw, Kaitlin, Genkinger, Jeanine, Manji, Gulam A, Iuga, Alina C, Schmid, Roland M, Johnson, Kristen, Badgley, Michael A, Lyssiotis, Costas A, Shah, Yatrik, Califano, Andrea, Olive, Kenneth P
Published in bioRxiv (22.06.2024)
Published in bioRxiv (22.06.2024)
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Journal Article
Author Correction: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, Urszula N., Jiang, Jingjing, Dalton, Tanner C., Curiel-Garcia, Alvaro, Edwards, A. Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A., Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A., Palermo, Carmine F., Hasselluhn, Marie C., Decker-Farrell, Amanda R., Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C., Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B., Clendenin, Cynthia, Sor, Rina, Vostrejs, William P., Hibshman, Priya S., Amparo, Amber M., Hennessey, Connor, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D., Herring, Laura E., Barker, Natalie K., Wang, Junning, Cleary, James M., Wolpin, Brian M., Chabot, John A., Kluger, Michael D., Manji, Gulam A., Tsai, Kenneth Y., Sekulic, Miroslav, Lagana, Stephen M., Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A. M., Holderfield, Matthew, Wildes, David, Lowe, Scott W., Badgley, Michael A., Aguirre, Andrew J., Vonderheide, Robert H., Stanger, Ben Z., Baslan, Timour, Der, Channing J., Singh, Mallika, Olive, Kenneth P.
Published in Nature (London) (12.11.2024)
Published in Nature (London) (12.11.2024)
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Journal Article
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
Wasko, Urszula N, Jiang, Jingjing, Dalton, Tanner C, Curiel-Garcia, Alvaro, Edwards, A Cole, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Tian, Sha, Stalnecker, Clint A, Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A, Palermo, Carmine F, Hasselluhn, Marie C, Decker-Farrell, Amanda R, Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C, Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Muonio, Karl, Zhao, Ruiping, Kemp, Samantha B, Clendenin, Cynthia, Sor, Rina, Vostrejs, William P, Hibshman, Priya S, Amparo, Amber M, Hennessey, Connor, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Brodbeck, Jens, Tomassoni, Lorenzo, Bakir, Basil, Socci, Nicholas D, Herring, Laura E, Barker, Natalie K, Wang, Junning, Cleary, James M, Wolpin, Brian M, Chabot, John A, Kluger, Michael D, Manji, Gulam A, Tsai, Kenneth Y, Sekulic, Miroslav, Lagana, Stephen M, Califano, Andrea, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A M, Holderfield, Matthew, Wildes, David, Lowe, Scott W, Badgley, Michael A, Aguirre, Andrew J, Vonderheide, Robert H, Stanger, Ben Z, Baslan, Timour, Der, Channing J, Singh, Mallika, Olive, Kenneth P
Published in Nature (London) (23.05.2024)
Published in Nature (London) (23.05.2024)
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Journal Article
Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma
Wasko, Urszula N, Jiang, Jingjing, Curiel-Garcia, Alvaro, Wang, Yingyun, Lee, Bianca, Orlen, Margo, Drizyte-Miller, Kristina, Menard, Marie, Dilly, Julien, Sastra, Stephen A, Palermo, Carmine F, Dalton, Tanner, Hasselluhn, Marie C, Decker-Farrell, Amanda R, Chang, Stephanie, Jiang, Lingyan, Wei, Xing, Yang, Yu C, Helland, Ciara, Courtney, Haley, Gindin, Yevgeniy, Zhao, Ruiping, Kemp, Samantha B, Clendenin, Cynthia, Sor, Rina, Vostrejs, Will, Amparo, Amber A, Hibshman, Priya S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Bakir, Basil, Badgley, Michael A, Chabot, John A, Kluger, Michael D, Manji, Gulam A, Quintana, Elsa, Wang, Zhengping, Smith, Jacqueline A M, Holderfield, Matthew, Wildes, David, Aguirre, Andrew J, Der, Channing J, Vonderheide, Robert H, Stanger, Ben Z, Singh, Mallika, Olive, Kenneth P
Published in bioRxiv (04.12.2023)
Published in bioRxiv (04.12.2023)
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Paper
Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia
Garcia-Bermudez, Javier, Prasad, Sheela, Baudrier, Lou, Badgley, Michael A, Liu, Yuyang, La, Konnor, Soula, Mariluz, Williams, Robert T, Yamaguchi, Norihiro, Hwang, Rosa F, Taylor, Laura J, De Stanchina, Elisa, Rostandy, Bety, Alwaseem, Hanan, Molina, Henrik, Bar-Sagi, Dafna, Birsoy, Kıvanç
Published in bioRxiv (03.02.2021)
Published in bioRxiv (03.02.2021)
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Paper
Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import
Badgley, Michael A, Kremer, Daniel, Maurer, H Carlo, Delgiorno, Kathleen E, Ho-Joon, Lee, Purohit, Vinee, Sagalovskiy, Irina, Ma, Alice, Kapillian, Jonathan, Firl, Christina Em, Decker, Amanda R, Sastra, Steve A, Palermo, Carmine F, Andrade, Leonardo R, Sajjakulnukit, Peter, Zhang, Li, Tolstyka, Zachary P, Hirschhorn, Tal, Lamb, Candice, Liu, Tong, Gu, Wei, Seeley, E Scott, Stone, Everett, Georgiou, George, Manor, Uri, Iuga, Alina, Wahl, Geoffrey M, Stockwell, Brent R, Lyssiotis, Costas A, Olive, Kenneth P
Published in bioRxiv (01.11.2019)
Published in bioRxiv (01.11.2019)
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