Human Immunodeficiency Virus Type 1 Mutations Selected in Patients Failing Efavirenz Combination Therapy
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Inhibition of Clinically Relevant Mutant Variants of HIV-1 by Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors
Corbett, Jeffrey W, Ko, Soo S, Rodgers, James D, Gearhart, Lisa A, Magnus, Nicholas A, Bacheler, Lee T, Diamond, Sharon, Jeffrey, Susan, Klabe, Ronald M, Cordova, Beverly C, Garber, Sena, Logue, Kelly, Trainor, George L, Anderson, Paul S, Erickson-Viitanen, Susan K
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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
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Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1
Corbett, J W, Ko, S S, Rodgers, J D, Jeffrey, S, Bacheler, L T, Klabe, R M, Diamond, S, Lai, C M, Rabel, S R, Saye, J A, Adams, S P, Trainor, G L, Anderson, P S, Erickson-Viitanen, S K
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Cyclic Urea Amides: HIV-1 Protease Inhibitors with Low Nanomolar Potency against both Wild Type and Protease Inhibitor Resistant Mutants of HIV
Jadhav, Prabhakar K, Ala, Paul, Woerner, Francis J, Chang, Chong-Hwan, Garber, Sena S, Anton, Elizabeth D, Bacheler, Lee T
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Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2′ substituents
Patel, Mona, Rodgers, James D., McHugh, Robert J., Johnson, Barry L., Cordova, Beverly C., Klabe, Ronald M., Bacheler, Lee T., Erickson-Viitanen, Susan, Ko, Soo S.
Published in Bioorganic & medicinal chemistry letters (15.11.1999)
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Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors
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Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies
Jadhav, Prabhakar K, Woerner, Francis J, Lam, Patrick Y. S, Hodge, C. Nicholas, Eyermann, Charles J, Man, Hon-Wah, Daneker, Wayne F, Bacheler, Lee T, Rayner, Marlene M, Meek, James L, Erickson-Viitanen, Susan, Jackson, David A, Calabrese, Joseph C, Schadt, Margaret, Chang, Chong-Hwan
Published in Journal of medicinal chemistry (23.04.1998)
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Nonsymmetric P2/P2‘ Cyclic Urea HIV Protease Inhibitors. Structure−Activity Relationship, Bioavailability, and Resistance Profile of Monoindazole-Substituted P2 Analogues
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Published in Journal of medicinal chemistry (18.06.1998)
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The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1′ residues
Patel, Mona, Bacheler, Lee T., Rayner, Marlene M., Cordova, Beverly C., Klabe, Ronald M., Erickson-Viitanen, Susan, Seitz, Steven P.
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
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Protease mutation M89I/V is linked to therapy failure in patients infected with the HIV-1 non-B subtypes C, F or G
ABECASIS, Ana Barroso, DEFORCHE, Koen, SNOECK, Joke, BACHELER, Lee T, MCKENNA, Paula, CARVALHO, Ana Patricia, GOMES, Perpétua, CAMACHO, Ricardo Jorge, VANDAMME, Anne-Mieke
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Multiple Mutations in the Human Immunodeficiency Virus Protease Gene Are Responsible for Decreased Susceptibility to Protease Inhibitors
King, R. W., Garber, S., Winslow, D. L., Reid, C., Bacheler, L. T., Anton, E., Otto, M. J.
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Published in Antiviral chemistry & chemotherapy (01.04.1995)
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The synthesis of symmetrical and unsymmetrical P1/P1′ cyclic ureas as HIV protease inhibitors
Patel, Mona, Kaltenbach, Robert F., Nugiel, David A., McHugh, Robert J., Jadhav, Prabhakar K., Bacheler, Lee T., Cordova, Beverly C., Klabe, Ronald M., Erickson-Viitanen, Susan, Garber, Sena, Reid, Carol, Seitz, Steven P.
Published in Bioorganic & medicinal chemistry letters (05.05.1998)
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Improved P1/P1‘ Substituents for Cyclic Urea Based HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationship, and X-ray Crystal Structure Analysis
Nugiel, David A, Jacobs, Kim, Cornelius, Lyndon, Chang, Chong-Hwan, Jadhav, Prabhakar K, Holler, Edward R, Klabe, Ronald M, Bacheler, Lee T, Cordova, Beverly, Garber, Sena, Reid, Carol, Logue, Kelly A, Gorey-Feret, Lorraine J, Lam, Gilbert N, Erickson-Viitanen, Susan, Seitz, Steven P
Published in Journal of medicinal chemistry (09.05.1997)
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Human Chromosome 12 is Required for Elevated HIV-1 Expression in Human-Hamster Hybrid Cells
Hart, Clyde E., Ou, Chin-Yih, Galphin, Judith C., Moore, Jennifer, Bacheler, Lee T., Wasmuth, John J., Petteway, Steven R., Schochetman, Gerald
Published in Science (American Association for the Advancement of Science) (27.10.1989)
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Rare mutations at codon 103 of HIV-1 reverse transcriptase can confer resistance to non-nucleoside reverse transcriptase inhibitors
HARRIGAN, P. Richard, MO, Theresa, WYNHOVEN, Brian, HIRSCH, Jennifer, BRUMME, Zabrina, MCKENNA, Paula, PATTERY, Theresa, VINGERHOETS, Johan, BACHELER, Lee T
Published in AIDS (London) (24.03.2005)
Published in AIDS (London) (24.03.2005)
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Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors
PATEL, Mona, MCHUGH, Robert J, CORDOVA, Beverly C, KLABE, Ronald M, BACHELER, Lee T, ERICKSON-VIITANEN, Susan, RODGERS, James D
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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Synthesis and Evaluation of Efavirenz (Sustiva TM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain
Cocuzza, Anthony J., Chidester, Dennis R., Cordova, Beverly C., Jeffrey, Susan, Parsons, Rodney L., Bacheler, Lee T., Erickson-Viitanen, Susan, Trainor, George L., Ko, Soo S.
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
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