Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir
Belema, Makonen, Nguyen, Van N., Bachand, Carol, Deon, Dan H., Goodrich, Jason T., James, Clint A., Lavoie, Rico, Lopez, Omar D., Martel, Alain, Romine, Jeffrey L., Ruediger, Edward H., Snyder, Lawrence B., Laurent, Denis R. St, Yang, Fukang, Zhu, Juliang, Wong, Henry S., Langley, David R., Adams, Stephen P., Cantor, Glenn H., Chimalakonda, Anjaneya, Fura, Aberra, Johnson, Benjamin M., Knipe, Jay O., Parker, Dawn D., Santone, Kenneth S., Fridell, Robert A., Lemm, Julie A., O’Boyle, Donald R., Colonno, Richard J., Gao, Min, Meanwell, Nicholas A., Hamann, Lawrence G.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
BMS-190394, a Selectin Inhibitor, Prevents Rat Cutaneous Inflammatory Reactions
Todderud, G, Nair, X, Lee, D, Alford, J, Davern, L, Stanley, P, Bachand, C, Lapointe, P, Marinier, A, Martel, A, Menard, M, Wright, J J, Bajorath, J, Hollenbaugh, D, Aruffo, A, Tramposch, K M
Published in The Journal of pharmacology and experimental therapeutics (01.09.1997)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.09.1997)
Journal Article
Anhydropenicillin: a key intermediate for the stereocontrolled introduction of the 6-R-hydroxyethyl side chain of the penem and carbapenem antibiotics
Martel, Alain, Daris, Jean-Paul, Bachand, Carol, Menard, Marcel
Published in Canadian journal of chemistry (01.09.1987)
Published in Canadian journal of chemistry (01.09.1987)
Get full text
Journal Article
Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11
Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
Get full text
Journal Article
HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, ST LAURENT DENIS R, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN
Year of Publication 01.10.2015
Get full text
Year of Publication 01.10.2015
Patent
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
Get full text
Journal Article
HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 02.06.2014
Get full text
Year of Publication 02.06.2014
Patent
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole-5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesson, David B., Kramer, Robert, Lee, Frank Y., Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C., Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M., Wong, Henry, Wright, John J., Zimmermann, Kurt, Vyas, Dolatrai M.
Published in Journal of medicinal chemistry (01.01.2005)
Published in Journal of medicinal chemistry (01.01.2005)
Get full text
Journal Article
HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 26.11.2010
Get full text
Year of Publication 26.11.2010
Patent
HETEROCYCLIC DERIVATIVES AS HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, MAKONEN BELEMA, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 24.11.2010
Get full text
Year of Publication 24.11.2010
Patent
CONFORMATIONALLY RESTRICTED BIPHENYL DERIVATIVES FOR USE AS HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 18.11.2010
Get full text
Year of Publication 18.11.2010
Patent
HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 26.10.2010
Get full text
Year of Publication 26.10.2010
Patent
IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS
MEANWELL NICHOLAS A, SNYDER LAWRENCE B, BACHAND CAROL, LAVOIE RICO, NGUYEN VAN N, ROMINE JEFFREY LEE, GOODRICH JASON, BELEMA MAKONEN, LOPEZ OMAR D, RUEDIGER EDWARD H, GOOD ANDREW C, HAMANN LAWRENCE G, DEON DANIEL H, WANG GAN, LANGLEY DAVID R, YANG FUKANG, JAMES CLINT A, MARTEL ALAIN, ST. LAURENT DENIS R
Year of Publication 21.10.2010
Get full text
Year of Publication 21.10.2010
Patent
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d -glucopyranosyl]-5 H ,13 H -benzo[ b ]- thienyl[2,3- a ]pyrrolo[3,4- c ]carbazole- 5,7(6 H )-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N., St. Laurent, Denis R., Saulnier, Mark G., Long, Byron H., Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R., Frennesson, David B., Kramer, Robert, Lee, Frank Y., Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C., Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M., Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M.
Published in Journal of medicinal chemistry (01.03.2004)
Published in Journal of medicinal chemistry (01.03.2004)
Get full text
Journal Article
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H, 13H-benzo[b]-thien yl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model
BALASUBRAMANIAN, Balu N, LAURENT, Denis R. St, FRENNESSON, David B, KRAMER, Robert, LEE, Frank Y, MAHLER, Mikael, MARTEL, Alain, NAIDU, B. Narasimhulu, ROSE, William C, RUSSELL, John, RUEDIGER, Edward, SOLOMON, Carola, SAULNIER, Mark G, STOFFAN, Karen M, WONG, Henry, ZIMMERMANN, Kurt, VYAS, Dolatrai M, LONG, Byron H, BACHAND, Carol, BEAULIEU, Francis, CLARKE, Wendy, DESHPANDE, Milind, EUMMER, Jeffrey, FAIRCHILD, Craig R
Published in Journal of medicinal chemistry (2004)
Get full text
Published in Journal of medicinal chemistry (2004)
Journal Article
Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model
Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Wright, John J, Zimmermann, Kurt, Vyas, Dolatrai M
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
Get full text
Journal Article
Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates
Marinier, Anne, Martel, Alain, Bachand, Carol, Plamondon, Serge, Turmel, Brigitte, Daris, Jean-Paul, Banville, Jacques, Lapointe, Philippe, Ouellet, Carl, Dextraze, Pierre, Menard, Marcel, Wright, John J.K, Alford, Julie, Lee, Debbie, Stanley, Paul, Nair, Xina, Todderud, Gordon, Tramposch, Kenneth M
Published in Bioorganic & medicinal chemistry (01.06.2001)
Published in Bioorganic & medicinal chemistry (01.06.2001)
Get full text
Journal Article