Radiographic read paradigms and the roles of the central imaging laboratory in neuro-oncology clinical trials
Ellingson, Benjamin M, Brown, Matthew S, Boxerman, Jerrold L, Gerstner, Elizabeth R, Kaufmann, Timothy J, Cole, Patricia E, Bacha, Jeffrey A, Leung, David, Barone, Amy, Colman, Howard, van den Bent, Martin J, Wen, Patrick Y, Alfred Yung, W K, Cloughesy, Timothy F, Goldin, Jonathan G
Published in Neuro-oncology (Charlottesville, Va.) (25.02.2021)
Published in Neuro-oncology (Charlottesville, Va.) (25.02.2021)
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Journal Article
Abstract 2157: Enhanced in vitro activity of dianhydrogalactitol (VAL-083) in combination with platinum drugs: Impact of p53 and platinum-resistance
Steino, Anne, He, Guanghan, Martinez-Rivera, Michelle, Bacha, Jeffrey A., Brown, Dennis M., Siddik, Zahid H.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Phase 2 clinical trial of VAL-083 as first-line treatment in newly-diagnosed MGMT-unmethylated glioblastoma multiforme (GBM): Halfway report
Guo, Chengcheng, Yang, Qunying, Li, Jiawei, Wu, Shaoxiong, Deng, Meiling, Du, Xiaojing, Sai, Ke, Jiang, Xiaobing, Chen, Zhenghe, Zhang, Ji, Lin, Fuhua, Wang, Jian, Chen, Yinsheng, Ke, Chao, Zhang, Xiangheng, Ju, Xue, Mou, Yonggao, Bacha, Jeffrey, Steino, Anne, Kanekal, Sarath, Kwan, Claire, Johnson, Gregory, Schwartz, Richard, Langlands, John, Brown, Dennis, Chen, Zhong-ping
Published in Glioma (01.01.2019)
Published in Glioma (01.01.2019)
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Abstract P053: VAL-083 (dianhydrogalactitol) synergizes with PARP inhibitors in BRCA-proficient and BRCA-deficient ovarian cancer models
Steino, Anne, He, Guangan, Zhai, Beibei, Bacha, Jeffrey, Brown, Dennis M., Daugaard, Mads, Siddik, Zahid H.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Abstract CT137: A pilot pharmacokinetic study of VAL413 in patients with recurrent pediatric solid tumors
Geller, James I., Brown, Dennis, Bacha, Jeffrey, Sankar, Neil, Kanekal, Sarath, Leggas, Mark, Wagner, Lars
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 1369: Dianhydrogalactitol (VAL-083) synergizes with topoisomerase inhibitors to overcome homologous recombination repair activity in glioblastoma and prostate cancer cells
Zhai, Beibei, Kotapalli, Sudha Sravanti, Bacha, Jeffrey A., Brown, Dennis M., Steino, Anne, Daugaard, Mads
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
A pilot clinical study of oral irinotecan HCl (VAL-413) in patients with recurrent pediatric solid tumors
Bacha, Jeffrey A., Brown, Dennis, Geller, James I., Oesterheld, Javier E., McManus, Meghann, Kanekal, Sarath, Leggas, Markos, Lopez, Lorena, Sankar, Neil, Yam, Noymi, Wagner, Lars M.
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Abstract P081: In vitro activity and efficacy of novel dual PARP-HDAC inhibitors
Truong, Sarah, Ghaidi, Fariba, Ramos, Louise, Joshi, Jay, Brown, Dennis, Sankar, Neil, Langlands, John, Bacha, Jeffrey, Shen, Wang, Daugaard, Mads
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
A pilot clinical study of VAL-413 (oral irinotecan HCl) in patients with recurrent pediatric solid tumors
Brown, Dennis, Bacha, Jeffrey A., Geller, James I., Thompson, Patrick A., Oesterheld, Javier E., Kanekal, Sarath, Leggas, Markos, Lopez, Lorena, Sankar, Neil, Yam, Noymi, Wagner, Lars M.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Abstract 1051: Dianhydrogalactitol (VAL-083) reduces glioblastoma tumor growth upon bevacizumab-induced hypoxia, in vivo
Golebiewska, Anna, Oudin, Anais, Steino, Anne, Niclou, Simone P., Bacha, Jeffrey, Brown, Dennis M.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 3499: Dianhydrogalactitol (VAL-083) in combination with AZD1775 increases survival in diffuse intrinsic pontine glioma (DIPG), in vivo
Steino, Anne, Yang, Xiaodong, Kline, Cassie, Bacha, Jeffrey, Brown, Dennis M., Mueller, Sabine
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma
Ramos, Louise, Truong, Sarah, Zhai, Beibei, Joshi, Jay, Ghaidi, Fariba, Lizardo, Michael M., Shyp, Taras, Kung, Sonia H.Y., Rezakhanlou, Alireza M., Oo, Htoo Zarni, Adomat, Hans, Le Bihan, Stephane, Collins, Colin, Bacha, Jeffrey, Brown, Dennis, Langlands, John, Shen, Wang, Lallous, Nada, Sorensen, Poul H., Daugaard, Mads
Published in Clinical cancer research (01.09.2023)
Published in Clinical cancer research (01.09.2023)
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CTNI-75. A PILOT CLINICAL TRIAL OF OROTECAN (VAL-413), A NOVEL ORAL DOSAGE FORMULATION OF IRINOTECAN: IMPLICATIONS FOR PEDIATRIC BRAIN TUMORS
Brown, Dennis, Bacha, Jeffrey, Wagner, Lars, Leggas, Markos, Kanekal, Sarath, Lopez, Lorena, Sankar, Neil
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
Published in Neuro-oncology (Charlottesville, Va.) (09.11.2020)
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