Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes
Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Babu Boga, Sobhana, Alhassan, Abdul-Basit, Yu, Wensheng, Selyutin, Oleg, Yu, Younong, Anand, Rajan, Xu, Jiayi, Kelly, Joseph, Duffy, Joseph L., Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Bennett, Chad, Maloney, Kevin M., Tyagarajan, Sriram, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Journal Article
Site-Selective Synthesis of Insulin Azides and Bioconjugates
Boga, Sobhana Babu, Krska, Shane W, Lin, Songnian, Pissarnitski, Dmitri, Yan, Lin, Kekec, Ahmet, Tang, Weijuan, Pierson, Nicholas A, Strulson, Christopher A, Streckfuss, Eric, Zhu, Xiaohong, Zhang, Xiaoping, Kelly, Terri, Parish, Craig A
Published in Bioconjugate chemistry (17.04.2019)
Published in Bioconjugate chemistry (17.04.2019)
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Journal Article
Stereoselective synthesis of a ketohexofuranose from an aldohexopyranose by a [6+1−1] strategy
Babu, Boga Sobhana, Balasubramanian, Kalpattu Kuppuswamy
Published in Carbohydrate research (21.03.2005)
Published in Carbohydrate research (21.03.2005)
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Journal Article
Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors
Morris, Erick J, Jha, Sharda, Restaino, Clifford R, Dayananth, Priya, Zhu, Hugh, Cooper, Alan, Carr, Donna, Deng, Yongi, Jin, Weihong, Black, Stuart, Long, Brian, Liu, Jenny, Dinunzio, Edward, Windsor, William, Zhang, Rumin, Zhao, Shuxia, Angagaw, Minilik H, Pinheiro, Elaine M, Desai, Jagdish, Xiao, Li, Shipps, Gerald, Hruza, Alan, Wang, James, Kelly, Joe, Paliwal, Sunil, Gao, Xiaolei, Babu, Boga Sobhana, Zhu, Liang, Daublain, Pierre, Zhang, Ling, Lutterbach, Bart A, Pelletier, Marc R, Philippar, Ulrike, Siliphaivanh, Phieng, Witter, David, Kirschmeier, Paul, Bishop, W Robert, Hicklin, Daniel, Gilliland, D Gary, Jayaraman, Lata, Zawel, Leigh, Fawell, Stephen, Samatar, Ahmed A
Published in Cancer discovery (01.07.2013)
Published in Cancer discovery (01.07.2013)
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Journal Article
Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology
Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Yao, Xin, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Hruza, Alan, Buevich, Alexei, Zhang, Li-Kang, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert
Published in Bioorganic & medicinal chemistry letters (15.06.2018)
Published in Bioorganic & medicinal chemistry letters (15.06.2018)
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Journal Article
MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology
Boga, Sobhana Babu, Deng, Yongqi, Zhu, Liang, Nan, Yang, Cooper, Alan B., Shipps, Gerald W., Doll, Ronald, Shih, Neng-Yang, Zhu, Hugh, Sun, Robert, Wang, Tong, Paliwal, Sunil, Tsui, Hon-Chung, Gao, Xiaolei, Yao, Xin, Desai, Jagdish, Wang, James, Alhassan, Abdul Basit, Kelly, Joseph, Patel, Mehul, Muppalla, Kiran, Gudipati, Subrahmanyam, Zhang, Li-Kang, Buevich, Alexei, Hesk, David, Carr, Donna, Dayananth, Priya, Black, Stuart, Mei, Hong, Cox, Kathleen, Sherborne, Bradley, Hruza, Alan W., Xiao, Li, Jin, Weihong, Long, Brian, Liu, Gongjie, Taylor, Stacey A., Kirschmeier, Paul, Windsor, William T., Bishop, Robert, Samatar, Ahmed A.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Journal Article
Discovery of novel BTK inhibitors with carboxylic acids
Gao, Xiaolei, Wang, James, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Selyutin, Oleg, Yu, Wensheng, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Cooper, Alan, Zhu, Hugh, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joeseph A.
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
Published in Bioorganic & medicinal chemistry letters (15.03.2017)
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Journal Article
Abstract 4788: Discovery of potent and selective inhibitors of ERK1/2 with a unique mechanism of action
Deng, Yongqi, Samatar, Ahmed, Shipps, Gerald, Cooper, Alan, Long, Brian, Carr, Donnar, Xiao, Li, Hruza, Alan, Wang, Tong, Zhu, Liang, Nan, Yang, Patel, Mehul, Muppalla, Kiran, Zhu, Hugh, Boga, Babu Sobhana, Gao, Xiaolei
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis
Boga, Sobhana Babu, Alhassan, Abdul-Basit, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Yu, Younong, Anand, Rajan, Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Zhu, Hugh, Desai, Jagdish, Maloney, Kevin, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Knemeyer, Ian, Garlisi, Charles G., Bays, Nathan, Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Cooper, Alan, Kim, Ronald M., Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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Journal Article
Discovery of 8‑Amino-imidazo[1,5‑a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis
Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Yu, Younong, Vaccaro, Henry, Liu, Shilan, Yang, Chundao, Wu, Hao, Cooper, Alan, de Man, Jos, Kaptein, Allard, Maloney, Kevin, Hornak, Viktor, Gao, Ying-Duo, Fischmann, Thierry O, Raaijmakers, Hans, Vu-Pham, Diep, Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G, Bays, Nathan, Stivers, Peter, Brandish, Philip E, Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Journal Article
Selective functionalization of complex heterocycles via an automated strong base screening platform
Boga, Sobhana Babu, Christensen, Melodie, Perrotto, Nicholas, Krska, Shane W., Dreher, Spencer, Tudge, Matthew T., Ashley, Eric R., Poirier, Marc, Reibarkh, Mikhail, Liu, Yong, Streckfuss, Eric, Campeau, Louis-Charles, Ruck, Rebecca T., Davies, Ian W., Vachal, Petr
Published in Reaction chemistry & engineering (01.08.2017)
Published in Reaction chemistry & engineering (01.08.2017)
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Journal Article
Structure-based drug design of clinical compound MK-8353, a novel inhibitor of ERK
Hruza, Alan, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Buevich, Alexei, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
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Journal Article
AZIDE INSULIN ANALOGUES
Lin, Songnian, Tang, Weijuan, Kekec, Ahmet, Yan, Lin, Parish, Craig A, Boga, Sobhana Babu
Year of Publication 16.11.2023
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Year of Publication 16.11.2023
Patent
Synthesis of 2,3-unsaturated thioglycopyranosides mediated by lithium tetrafluoroborate
Babu, Boga Sobhana, Balasubramanian, Kalpattu Kuppuswamy
Published in Tetrahedron letters (30.07.1999)
Published in Tetrahedron letters (30.07.1999)
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Journal Article
MACROCYCLIC COMPOUNDS
ABRAHAM, Sunny, PALIWAL, Sunil, BUNKER, Kevin, Duane, ZHANG, Junhu, BOGA, Sobhana, Babu, HUANG, Peter, Qinhua, BOREN, Brant, Clayton, JIANG, Wanlong
Year of Publication 10.01.2024
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Year of Publication 10.01.2024
Patent
CHIRAL SYNTHESIS OF A TERTIARY ALCOHOL
ABRAHAM, Sunny, BUNKER, Kevin, Duane, PRATT, Benjamin, Anthony, BOGA, Sobhana, Babu, UNNI, Aditya, Krishnan, HUANG, Peter, Qinhua, BOREN, Brant, Clayton
Year of Publication 29.11.2023
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Year of Publication 29.11.2023
Patent
MACROCYCLIC COMPOUNDS
ABRAHAM, Sunny, PALIWAL, Sunil, BUNKER, Kevin, Duane, ZHANG, Junhu, BOGA, Sobhana, Babu, HUANG, Peter, Qinhua, BOREN, Brant, Clayton, JIANG, Wanlong
Year of Publication 05.07.2023
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Year of Publication 05.07.2023
Patent
MACROCYCLIC COMPOUNDS
Abraham, Sunny, Paliwal, Sunil, Bunker, Kevin Duane, Zhang, Junhu, Boren, Brant Clayton, Huang, Peter Qinhua, Boga, Sobhana Babu, Jiang, Wanlong
Year of Publication 22.06.2023
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Year of Publication 22.06.2023
Patent