The molecular regulation of Janus kinase (JAK) activation
Babon, Jeffrey J, Lucet, Isabelle S, Murphy, James M, Nicola, Nicos A, Varghese, Leila N
Published in Biochemical journal (15.08.2014)
Published in Biochemical journal (15.08.2014)
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The molecular basis of JAK/STAT inhibition by SOCS1
Liau, Nicholas P D, Laktyushin, Artem, Lucet, Isabelle S, Murphy, James M, Yao, Shenggen, Whitlock, Eden, Callaghan, Kimberley, Nicola, Nicos A, Kershaw, Nadia J, Babon, Jeffrey J
Published in Nature communications (19.04.2018)
Published in Nature communications (19.04.2018)
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Journal Article
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.
Published in Immunity (Cambridge, Mass.) (19.09.2013)
Published in Immunity (Cambridge, Mass.) (19.09.2013)
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Inhibition of IL-6 family cytokines by SOCS3
Babon, Jeffrey J, Varghese, Leila N, Nicola, Nicos A
Published in Seminars in immunology (01.02.2014)
Published in Seminars in immunology (01.02.2014)
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Journal Article
Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.
Published in Immunity (Cambridge, Mass.) (24.02.2012)
Published in Immunity (Cambridge, Mass.) (24.02.2012)
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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Hildebrand, Joanne M., Tanzer, Maria C., Lucet, Isabelle S., Young, Samuel N., Spall, Sukhdeep K., Sharma, Pooja, Pierotti, Catia, Garnier, Jean-Marc, Dobson, Renwick C.J., Webb, Andrew I., Tripaydonis, Anne, Babon, Jeffrey J., Mulcair, Mark D., Scanlon, Martin J., Alexander, Warren S., Wilks, Andrew F., Czabotar, Peter E., Lessene, Guillaume, Murphy, James M., Silke, John
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2014)
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Persistence of myelofibrosis treated with ruxolitinib: biology and clinical implications
Ross, David M, Babon, Jeffrey J, Tvorogov, Denis, Thomas, Daniel
Published in Haematologica (Roma) (01.05.2021)
Published in Haematologica (Roma) (01.05.2021)
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NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS
Louis, Cynthia, Souza-Fonseca-Guimaraes, Fernando, Yang, Yuyan, D'Silva, Damian, Kratina, Tobias, Dagley, Laura, Hediyeh-Zadeh, Soroor, Rautela, Jai, Masters, Seth Lucian, Davis, Melissa J, Babon, Jeffrey J, Ciric, Bogoljub, Vivier, Eric, Alexander, Warren S, Huntington, Nicholas D, Wicks, Ian P
Published in The Journal of experimental medicine (04.05.2020)
Published in The Journal of experimental medicine (04.05.2020)
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A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity
Liang, Shuwei, Tran, Eric, Du, Xin, Dong, Jiajun, Sudholz, Harrison, Chen, Hao, Qu, Zihan, Huntington, Nicholas D, Babon, Jeffrey J, Kershaw, Nadia J, Zhang, Zhong-Yin, Baell, Jonathan B, Wiede, Florian, Tiganis, Tony
Published in Nature communications (27.07.2023)
Published in Nature communications (27.07.2023)
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Journal Article
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition
Kershaw, Nadia J, Murphy, James M, Liau, Nicholas P D, Varghese, Leila N, Laktyushin, Artem, Whitlock, Eden L, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J
Published in Nature structural & molecular biology (01.04.2013)
Published in Nature structural & molecular biology (01.04.2013)
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Journal Article
Suppression of cytokine signaling: The SOCS perspective
Linossi, Edmond M, Babon, Jeffrey J, Hilton, Douglas J, Nicholson, Sandra E
Published in Cytokine & growth factor reviews (01.06.2013)
Published in Cytokine & growth factor reviews (01.06.2013)
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Journal Article
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
Murphy, James M, Zhang, Qingwei, Young, Samuel N, Reese, Michael L, Bailey, Fiona P, Eyers, Patrick A, Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N, Chen, Kelan, Tripaydonis, Anne, Jura, Natalia, Fukuda, Koichi, Qin, Jun, Nimchuk, Zachary, Mudgett, Mary Beth, Elowe, Sabine, Gee, Christine L, Liu, Ling, Daly, Roger J, Manning, Gerard, Babon, Jeffrey J, Lucet, Isabelle S
Published in Biochemical journal (15.01.2014)
Published in Biochemical journal (15.01.2014)
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Journal Article
Small molecule drug discovery targeting the JAK-STAT pathway
Lv, You, Mi, Pengbing, Babon, Jeffrey J., Fan, Guohuang, Qi, Jianxun, Cao, Longxing, Lang, Jiajia, Zhang, Jin, Wang, Faming, Kobe, Bostjan
Published in Pharmacological research (01.06.2024)
Published in Pharmacological research (01.06.2024)
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Journal Article
The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis
Morris, Rhiannon, Butler, Liesl, Perkins, Andrew, Kershaw, Nadia J, Babon, Jeffrey J
Published in Pharmaceuticals (Basel, Switzerland) (24.12.2021)
Published in Pharmaceuticals (Basel, Switzerland) (24.12.2021)
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Journal Article
Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK
Morris, Rhiannon, Zhang, Yaoyuan, Ellyard, Julia I, Vinuesa, Carola G, Murphy, James M, Laktyushin, Artem, Kershaw, Nadia J, Babon, Jeffrey J
Published in Nature communications (20.10.2021)
Published in Nature communications (20.10.2021)
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Journal Article
Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity
D'Cruz, Akshay A, Babon, Jeffrey J, Norton, Raymond S, Nicola, Nicos A, Nicholson, Sandra E
Published in Protein science (01.01.2013)
Published in Protein science (01.01.2013)
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Journal Article
Regulation of Janus kinases by SOCS proteins
Kershaw, Nadia J, Murphy, James M, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J
Published in Biochemical Society transactions (01.08.2013)
Published in Biochemical Society transactions (01.08.2013)
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Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
Murphy, James M, Lucet, Isabelle S, Hildebrand, Joanne M, Tanzer, Maria C, Young, Samuel N, Sharma, Pooja, Lessene, Guillaume, Alexander, Warren S, Babon, Jeffrey J, Silke, John, Czabotar, Peter E
Published in Biochemical journal (01.02.2014)
Published in Biochemical journal (01.02.2014)
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