Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
McCauley, John A, McIntyre, Charles J, Rudd, Michael T, Nguyen, Kevin T, Romano, Joseph J, Butcher, John W, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Mao, Shi-Shan, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease
Liverton, Nigel J, Holloway, M. Katharine, McCauley, John A, Rudd, Michael T, Butcher, John W, Carroll, Steven S, DiMuzio, Jillian, Fandozzi, Christine, Gilbert, Kevin F, Mao, Shi-Shan, McIntyre, Charles J, Nguyen, Kevin T, Romano, Joseph J, Stahlhut, Mark, Wan, Bang-Lin, Olsen, David B, Vacca, Joseph P
Published in Journal of the American Chemical Society (09.04.2008)
Published in Journal of the American Chemical Society (09.04.2008)
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Overcoming Mutagenicity and Ion Channel Activity: Optimization of Selective Spleen Tyrosine Kinase Inhibitors
Ellis, J. Michael, Altman, Michael D, Bass, Alan, Butcher, John W, Byford, Alan J, Donofrio, Anthony, Galloway, Sheila, Haidle, Andrew M, Jewell, James, Kelly, Nancy, Leccese, Erica K, Lee, Sandra, Maddess, Matthew, Miller, J. Richard, Moy, Lily Y, Osimboni, Ekundayo, Otte, Ryan D, Reddy, M. Vijay, Spencer, Kerrie, Sun, Binyuan, Vincent, Stella H, Ward, Gwendolyn J, Woo, Grace H. C, Yang, Chiming, Houshyar, Hani, Northrup, Alan B
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma
Huang, Xianhai, Brubaker, Jason, Zhou, Wei, Biju, Purakkattle J., Xiao, Li, Shao, Ning, Huang, Ying, Dong, Li, Liu, Zhidan, Bitar, Rema, Buevich, Alexei, Jung, Joon, Peterson, Scott L., Butcher, John W., Close, Joshua, Martinez, Michelle, MacCoss, Rachel N., Zhang, Hongjun, Crawford, Scott, McCormick, Kevin D., Aslanian, Robert, Nargund, Ravi, Correll, Craig, Gervais, Francois, Qiu, Hongchen, Yang, Xiaoxin, Garlisi, Charles, Rindgen, Diane, Maloney, Kevin M., Siliphaivanh, Phieng, Palani, Anandan
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325
Rudd, Michael T., Butcher, John W., Nguyen, Kevin T., McIntyre, Charles J., Romano, Joseph J., Gilbert, Kevin F., Bush, Kimberly J., Liverton, Nigel J., Holloway, M. Katharine, Harper, Steven, Ferrara, Marco, DiFilippo, Marcello, Summa, Vincenzo, Swestock, John, Fritzen, Jeff, Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark W., Black, Stuart, Chase, Robert, Soriano, Aileen, Fandozzi, Christine M., Taylor, Anne, Trainor, Nicole, Olsen, David B., Coleman, Paul J., Ludmerer, Steven W., McCauley, John A.
Published in ChemMedChem (01.04.2015)
Published in ChemMedChem (01.04.2015)
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Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist
Liverton, Nigel J, Bednar, Rodney A, Bednar, Bohumil, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Cunningham, Michael, DiLella, Anthony G, Gaul, Stanley L, Libby, Brian E, Lyle, Elizabeth A, Lynch, Joseph J, McCauley, John A, Mosser, Scott D, Nguyen, Kevin T, Stump, Gary L, Sun, Hong, Wang, Hao, Yergey, James, Koblan, Kenneth S
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers
Rudd, Michael T., McIntyre, Charles J., Romano, Joseph J., Butcher, John W., Holloway, M. Katharine, Bush, Kimberly, Nguyen, Kevin T., Gilbert, Kevin F., Lyle, Terry A., Liverton, Nigel J., Wan, Bang-Lin, Summa, Vincenzo, Harper, Steven, Rowley, Michael, Vacca, Joseph P., Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, Ludmerer, Steven W., McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark, Fandozzi, Christine, Taylor, Anne, Trainor, Nicole, Olsen, David B., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease
Rudd, Michael T., McCauley, John A., Romano, Joseph J., Butcher, John W., Bush, Kimberly, McIntyre, Charles J., Nguyen, Kevin T., Gilbert, Kevin F., Lyle, Terry A., Holloway, M. Katharine, Wan, Bang-Lin, Vacca, Joseph P., Summa, Vincenzo, Harper, Steven, Rowley, Michael, Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, Ludmerer, Steven W., McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark, Fandozzi, Christine, Taylor, Anne, Trainor, Nicole, Olsen, David B., Liverton, Nigel J.
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
Published in Bioorganic & medicinal chemistry letters (01.12.2012)
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Journal Article
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure
Rudd, Michael T, McCauley, John A, Butcher, John W, Romano, Joseph J, McIntyre, Charles J, Nguyen, Kevin T, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J
Published in ACS medicinal chemistry letters (10.03.2011)
Published in ACS medicinal chemistry letters (10.03.2011)
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Journal Article
P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation HepatitisC Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325
Rudd, Michael T, Butcher, John W, Nguyen, Kevin T, McIntyre, Charles J, Romano, Joseph J, Gilbert, Kevin F, Bush, Kimberly J, Liverton, Nigel J, Holloway, M Katharine, Harper, Steven, Ferrara, Marco, DiFilippo, Marcello, Summa, Vincenzo, Swestock, John, Fritzen, Jeff, Carroll, Steven S, Burlein, Christine, DiMuzio, Jillian M, Gates, Adam, Graham, Donald J, Huang, Qian, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark W, Black, Stuart, Chase, Robert, Soriano, Aileen, Fandozzi, Christine M, Taylor, Anne, Trainor, Nicole, Olsen, David B, Coleman, Paul J, Ludmerer, Steven W, McCauley, John A
Published in ChemMedChem (01.04.2015)
Published in ChemMedChem (01.04.2015)
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Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists
McIntyre, Charles J., McCauley, John A., Bednar, Bohumil, Bednar, Rodney A., Butcher, John W., Claremon, David A., Cunningham, Michael E., Freidinger, Roger M., Gaul, Stanley L., Homnick, Carl F., Koblan, Ken S., Mosser, Scott D., Romano, Joseph J., Liverton, Nigel J.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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A new series of potent benzodiazepine γ-secretase inhibitors
Churcher, Ian, Ashton, Kate, Butcher, John W., Clarke, Earl E., Harrison, Timothy, Lewis, Huw D., Owens, Andrew P., Teall, Martin R., Williams, Susie, Wrigley, Jonathan D.J.
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
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Synthesis of the first sulfur-35-labeled hERG radioligand
Raab, Conrad E., Butcher, John W., Connolly, Thomas M., Karczewski, Jerzy, Yu, Nathan X., Staskiewicz, Steven J., Liverton, Nigel, Dean, Dennis C., Melillo, David G.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide
Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh
Published in Journal of medicinal chemistry (21.11.1997)
Published in Journal of medicinal chemistry (21.11.1997)
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A versatile synthesis of 1,1-dioxo 7-substituted cephems: preparation of the human leukocyte elastase (HLE) inhibitor 1,1-dioxo-trans-7-methoxycephalosporanic acid tert-butyl ester
Blacklock, Thomas J, Butcher, John W, Sohar, Paul, Lamanec, Theresa Rothauser, Grabowski, Edward J. J
Published in Journal of organic chemistry (01.08.1989)
Published in Journal of organic chemistry (01.08.1989)
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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective Iks-blocking class III antiarrhythmic agents
BUTCHER, John W, LIVERTON, Nigel J, VYAS, Kamlesh, CLAREMON, David A, FREIDINGER, Roger M, JURKIEWICZ, Nancy K, LYNCH, Joseph J, SALATA, Joseph J, JIXIN WANG, DIECKHAUS, Christine M, SLAUGHTER, Donald E
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
Harper, Steven, McCauley, John A, Rudd, Michael T, Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W, Romano, Joseph J, Bush, Kimberly J, Gilbert, Kevin F, McIntyre, Charles J, Nguyen, Kevin T, Nizi, Emanuela, Carroll, Steven S, Ludmerer, Steven W, Burlein, Christine, DiMuzio, Jillian M, Graham, Donald J, McHale, Carolyn M, Stahlhut, Mark W, Olsen, David B, Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M, Rowley, Michael, Coleman, Paul J, Vacca, Joseph P, Summa, Vincenzo, Liverton, Nigel J
Published in ACS medicinal chemistry letters (12.04.2012)
Published in ACS medicinal chemistry letters (12.04.2012)
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Journal Article
Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis CNS3/4A protease
Liverton, Nigel J., Holloway, M. Katharine, McCauley, John A., Rudd, Michael T., Butcher, John W., Carroll, Steven S., DiMuzio, Jillian, Fandozzi, Christine, Gilbert, Kevin F., Mao, Shi-Shan, Mclntyre, Charles J., Nguyen, Kevin T., Romano, Joseph J., Stahlhut, Mark, Wan, Bang-Lin, Olsen, David B., Vacca, Joseph P.
Published in Journal of the American Chemical Society (09.04.2008)
Published in Journal of the American Chemical Society (09.04.2008)
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CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH?? RECEPTOR MODULATORS
HUANG YING, BUTCHER JOHN W, DONG LI, PALANI ANANDAN, ASLANIAN ROBERT G, SILIPHAIVANH PHIENG, SHAO NING, ZHOU WEI, CLOSE JOSHUA T, BRUBAKER JASON, PETERSON SCOTT L, MACCOSS RACHEL NICOLA, ZHANG HONGJUN, MCCORMICK KEVIN D, HUANG XIANHAI, JUNG JOON O, BIJU PURAKKATTLE JOHNY, MARTINEZ MICHELLE
Year of Publication 04.03.2014
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Year of Publication 04.03.2014
Patent
Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters
Doherty, James B, Ashe, Bonnie M, Barker, Peter L, Blacklock, Thomas J, Butcher, John W, Chandler, Gilbert O, Dahlgren, M. Ellen, Davies, Philip, Dorn, Conrad P
Published in Journal of medicinal chemistry (01.09.1990)
Published in Journal of medicinal chemistry (01.09.1990)
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