Search Results - "BUTCHER, JW" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

by Liverton, Nigel J, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Libby, Brian E, Nguyen, Kevin T, Pitzenberger, Steven M, Selnick, Harold G, Smith, Garry R, Tebben, Andrew, Vacca, Joseph P, Varga, Sandor L, Agarwal, Lily, Dancheck, Kim, Forsyth, Amy J, Fletcher, Daniel S, Frantz, Betsy, Hanlon, William A, Harper, Coral F, Hofsess, Scott J, Kostura, Matthew, Lin, Jiunn, Luell, Sylvie, O'Neill, Edward A, Orevillo, Chad J, Pang, Margaret, Parsons, Janey, Rolando, Anna, Sahly, Yousif, Visco, Denise M, O'Keefe, Stephen J
Published in Journal of medicinal chemistry (17.06.1999)

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A new series of potent benzodiazepine γ-secretase inhibitors

A new series of potent benzodiazepine γ-secretase inhibitors

by Churcher, Ian, Ashton, Kate, Butcher, John W., Clarke, Earl E., Harrison, Timothy, Lewis, Huw D., Owens, Andrew P., Teall, Martin R., Williams, Susie, Wrigley, Jonathan D.J.
Published in Bioorganic & medicinal chemistry letters (20.01.2003)

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Synthesis of the first sulfur-35-labeled hERG radioligand

Synthesis of the first sulfur-35-labeled hERG radioligand

by Raab, Conrad E., Butcher, John W., Connolly, Thomas M., Karczewski, Jerzy, Yu, Nathan X., Staskiewicz, Steven J., Liverton, Nigel, Dean, Dennis C., Melillo, David G.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)

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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

by Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh
Published in Journal of medicinal chemistry (21.11.1997)

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I Ks-blocking class III antiarrhythmic agents

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I Ks-blocking class III antiarrhythmic agents

by Butcher, John W, Liverton, Nigel J, Claremon, David A, Freidinger, Roger M, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Wang, Jixin, Dieckhaus, Christine M, Slaughter, Donald E, Vyas, Kamlesh
Published in Bioorganic & medicinal chemistry letters (24.03.2003)

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An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507: 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride

An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507: 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride

by Blacklock, Thomas J., Sohar, Paul, Butcher, John W., Lamanec, T., Grabowski, E. J. J.
Published in Journal of organic chemistry (01.03.1993)

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K+ channel blockade in the NTS alters efficacy of two cardiorespiratory reflexes in vivo

K+ channel blockade in the NTS alters efficacy of two cardiorespiratory reflexes in vivo

by Butcher, James W, Paton, Julian F. R
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.03.1998)

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Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

by Butcher, John W., Liverton, Nigel J., Selnick, Harold G., Elliot, Jason M., Smith, Garry R., Tebben, Andrew J., Pribush, David A., Wai, John S., Claremon, David A.
Published in Tetrahedron letters (09.09.1996)

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Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters

by Doherty, James B, Ashe, Bonnie M, Barker, Peter L, Blacklock, Thomas J, Butcher, John W, Chandler, Gilbert O, Dahlgren, M. Ellen, Davies, Philip, Dorn, Conrad P
Published in Journal of medicinal chemistry (01.09.1990)

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ONE-POT SYNTHESIS OF SPIRO ISOCHROMANE-3,3'-PIPERIDINES, -3,4'-PIPERIDINES AND -3,3'-PYRROLIDINES

ONE-POT SYNTHESIS OF SPIRO ISOCHROMANE-3,3'-PIPERIDINES, -3,4'-PIPERIDINES AND -3,3'-PYRROLIDINES

by BUTCHER, JW, CLAREMON, DA
Published in Synthesis (Stuttgart) (1993)

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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide

by SELNICK, Harold G., LIVERTON, Nigel J., BALDWIN, John J., BUTCHER, John W., CLAREMON, David A., ELLIOTT, Jason M., FREIDINGER, Roger M., KING, Stella A., LIBBY, Brian E., MCINTYRE, Charles J., PRIBUSH, David A., REMY, David C., SMITH, Garry R., TEBBEN, Andrew J., JURKIEWICZ, Nancy K., LYNCH, Joseph J., SALATA, Joseph J., SANGUINETTI, Michael C., SIEGL, Peter K. S., SLAUGHTER, Donald E., VYAS, Kamlesh
Published in Journal of medicinal chemistry (21.11.1997)

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Preparation and trapping of 3-lithium-O-lithiophenoxide

Preparation and trapping of 3-lithium-O-lithiophenoxide

by Selnick, Harold G., Bourgeois, Michelle L., Butcher, John W., Radzilowski, Ellen M.
Published in Tetrahedron letters (26.03.1993)

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Synthesis of semisynthetic dipeptides using N-carboxyanhydrides and chiral induction on Raney nickel. A method practical for large scale

Synthesis of semisynthetic dipeptides using N-carboxyanhydrides and chiral induction on Raney nickel. A method practical for large scale

by Blacklock, Thomas J., Shuman, Richard F., Butcher, John W., Shearin, Willard E., Budavari, John, Grenda, Victor J.
Published in Journal of organic chemistry (01.02.1988)

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A versatile synthesis of 1,1-dioxo 7-substituted cephems: preparation of the human leukocyte elastase (HLE) inhibitor 1,1-dioxo-trans-7-methoxycephalosporanic acid tert-butyl ester

A versatile synthesis of 1,1-dioxo 7-substituted cephems: preparation of the human leukocyte elastase (HLE) inhibitor 1,1-dioxo-trans-7-methoxycephalosporanic acid tert-butyl ester

by Blacklock, Thomas J, Butcher, John W, Sohar, Paul, Lamanec, Theresa Rothauser, Grabowski, Edward J. J
Published in Journal of organic chemistry (01.08.1989)

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4-OXOSPIRO[BENZOPYRAN-2,4'-PIPERIDINES] AS CLASS-III ANTIARRHYTHMIC AGENTS - PHARMACOLOGICAL STUDIES ON 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL)-ETHYL]-6-METHANESULFONAMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE (L-691,121)

4-OXOSPIRO[BENZOPYRAN-2,4'-PIPERIDINES] AS CLASS-III ANTIARRHYTHMIC AGENTS - PHARMACOLOGICAL STUDIES ON 3,4-DIHYDRO-1'-[2-(BENZOFURAZAN-5-YL)-ETHYL]-6-METHANESULFONAMIDOSPIRO[(2H)-1-BENZOPYRAN-2,4'-PIPERIDIN]-4-ONE (L-691,121)

by ELLIOTT, JM, SELNICK, HG, CLAREMON, DA, BALDWIN, JJ, BUHROW, SA, BUTCHER, JW, HABECKER, CN, KING, SW, LYNCH, JJ, PHILLIPS, BT, PONTICELLO, GS, RADZILOWSKI, EM, REMY, DC, STEIN, RB, WHITE, JI, YOUNG, MB
Published in Journal of medicinal chemistry (16.10.1992)

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Angiotensin II receptors within the nucleus of the solitary tract mediate the developmental attenuation of the baroreceptor vagal reflex in pre-weaned rats

Angiotensin II receptors within the nucleus of the solitary tract mediate the developmental attenuation of the baroreceptor vagal reflex in pre-weaned rats

by Kasparov, Sergey, Butcher, James W, Paton, Julian F.R
Published in Journal of the autonomic nervous system (11.12.1998)

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Cardiorespiratory reflexes in mice

Cardiorespiratory reflexes in mice

by Paton, Julian F.R, Butcher, James W
Published in Journal of the autonomic nervous system (19.01.1998)

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Bioecology of edaphic Collembola and Acarina

Bioecology of edaphic Collembola and Acarina

by Butcher, J.W, Snider, R, Snider, R.J
Published in Annual review of entomology (1971)

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Cold hardiness of Dendrosoter protuberans

Cold hardiness of Dendrosoter protuberans

by Truchan, J, Butcher, J.W
Published in Journal of economic entomology (1970)

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Comparison of cardiorespiratory reflexes in NK1 receptor knockout, heterozygous and wild-type mice in vivo

Comparison of cardiorespiratory reflexes in NK1 receptor knockout, heterozygous and wild-type mice in vivo

by BUTCHER, J. W, DE FELIPE, C, SMITH, A. J. H, HUNT, S. P, PATON, J. F. R
Published in Journal of the autonomic nervous system (30.04.1998)

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