Oxidative stress changes the effectiveness of artemisinin in Plasmodium falciparum
Pires, Camilla Valente, Cassandra, Debora, Xu, Shulin, Laleu, Benoit, Burrows, Jeremy N, Adams, John H
Published in mBio (13.03.2024)
Published in mBio (13.03.2024)
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Journal Article
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
Xie, Stanley C, Gillett, David L, Spillman, Natalie J, Tsu, Christopher, Luth, Madeline R, Ottilie, Sabine, Duffy, Sandra, Gould, Alexandra E, Hales, Paul, Seager, Benjamin A, Charron, Carlie L, Bruzzese, Frank, Yang, Xiaofeng, Zhao, Xiansi, Huang, Shih-Chung, Hutton, Craig A, Burrows, Jeremy N, Winzeler, Elizabeth A, Avery, Vicky M, Dick, Lawrence R, Tilley, Leann
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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An in vitro toolbox to accelerate anti-malarial drug discovery and development
Charman, Susan A, Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C K, Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M, White, Karen L, Almond, Lisa, Dickins, Maurice, Smith, Dennis A, Moehrle, Joerg J, Burrows, Jeremy N, Abla, Nada
Published in Malaria journal (02.01.2020)
Published in Malaria journal (02.01.2020)
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Journal Article
Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers
Nilsen, Aaron, Miley, Galen P, Forquer, Isaac P, Mather, Michael W, Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M, Stickles, Allison M, Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L, Hinrichs, David J, Winter, Rolf W, Charman, Susan A, Zakharov, Lev N, Bathurst, Ian, Burrows, Jeremy N, Vaidya, Akhil B, Riscoe, Michael K
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
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Journal Article
Defining the biology component of the drug discovery strategy for malaria eradication
Leroy, Didier, Campo, Brice, Ding, Xavier C, Burrows, Jeremy N, Cherbuin, Stéphanie
Published in Trends in parasitology (01.10.2014)
Published in Trends in parasitology (01.10.2014)
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Journal Article
Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
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Journal Article
Antimalarial drug discovery – the path towards eradication
BURROWS, JEREMY N, BURLOT, EMILIE, CAMPO, BRICE, CHERBUIN, STEPHANIE, JEANNERET, SARAH, LEROY, DIDIER, SPANGENBERG, THOMAS, WATERSON, DAVID, WELLS, TIMOTHY NC, WILLIS, PAUL
Published in Parasitology (01.01.2014)
Published in Parasitology (01.01.2014)
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Journal Article
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
Coteron, Jose M, Marco, María, Esquivias, Jorge, Deng, Xiaoyi, White, Karen L, White, John, Koltun, Maria, El Mazouni, Farah, Kokkonda, Sreekanth, Katneni, Kasiram, Bhamidipati, Ravi, Shackleford, David M, Angulo-Barturen, Iñigo, Ferrer, Santiago B, Jiménez-Díaz, María Belén, Gamo, Francisco-Javier, Goldsmith, Elizabeth J, Charman, William N, Bathurst, Ian, Floyd, David, Matthews, David, Burrows, Jeremy N, Rathod, Pradipsinh K, Charman, Susan A, Phillips, Margaret A
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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Journal Article
Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)‑Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property Relationship Studies
Neelarapu, Raghupathi, Maignan, Jordany R, Lichorowic, Cynthia L, Monastyrskyi, Andrii, Mutka, Tina S, LaCrue, Alexis N, Blake, Lynn D, Casandra, Debora, Mashkouri, Sherwin, Burrows, Jeremy N, Willis, Paul A, Kyle, Dennis E, Manetsch, Roman
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Journal Article
Optimization of diastereomeric dihydropyridines as antimalarials
Van Horn, Kurt S., Zhao, Yingzhao, Parvatkar, Prakash T., Maier, Julie, Mutka, Tina, Lacrue, Alexis, Brockmeier, Fabian, Ebert, Daniel, Wu, Wesley, Casandra, Debora R., Namelikonda, Niranjan, Yacoub, Jeanine, Sigal, Martina, Knapp, Spencer, Floyd, David, Waterson, David, Burrows, Jeremy N., Duffy, James, DeRisi, Joseph L., Kyle, Dennis E., Guy, R. Kiplin, Manetsch, Roman
Published in European journal of medicinal chemistry (05.09.2024)
Published in European journal of medicinal chemistry (05.09.2024)
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Journal Article
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
Palmer, Michael J, Deng, Xiaoyi, Watts, Shawn, Krilov, Goran, Gerasyuto, Aleksey, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, White, Karen L, Striepen, Josefine, Bath, Jade, Schindler, Kyra A, Yeo, Tomas, Shackleford, David M, Mok, Sachel, Deni, Ioanna, Lawong, Aloysus, Huang, Ann, Chen, Gong, Wang, Wen, Jayaseelan, Jaya, Katneni, Kasiram, Patil, Rahul, Saunders, Jessica, Shahi, Shatrughan P, Chittimalla, Rajesh, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Wittlin, Sergio, Tumwebaze, Patrick K, Rosenthal, Philip J, Cooper, Roland A, Aguiar, Anna Caroline Campos, Guido, Rafael V. C, Pereira, Dhelio B, Mittal, Nimisha, Winzeler, Elizabeth A, Tomchick, Diana R, Laleu, Benoît, Burrows, Jeremy N, Rathod, Pradipsinh K, Fidock, David A, Charman, Susan A, Phillips, Margaret A
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Journal Article
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Journal Article
Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria
Macintyre, Fiona, Ramachandruni, Hanu, Burrows, Jeremy N, Holm, René, Thomas, Anna, Möhrle, Jörg J, Duparc, Stephan, Hooft van Huijsduijnen, Rob, Greenwood, Brian, Gutteridge, Winston E, Wells, Timothy N C, Kaszubska, Wiweka
Published in Malaria journal (01.11.2018)
Published in Malaria journal (01.11.2018)
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Journal Article
Discovery of 1,3,4-oxadiazoles with slow-action activity against Plasmodium falciparum malaria parasites
Andrews, Katherine T., Fisher, Gillian M., Firmin, Meaghan, Liepa, Andris J., Wilson, Tony, Gardiner, James, Mohri, Yacine, Debele, Emmanuel, Rai, Anjana, Davey, Andrew K., Masurier, Antoine, Delion, Alix, Mouratidis, Alexandros A., Hutt, Oliver E., Forsyth, Craig M., Burrows, Jeremy N., Ryan, John H., Riches, Andrew G., Skinner-Adams, Tina S.
Published in European journal of medicinal chemistry (15.11.2024)
Published in European journal of medicinal chemistry (15.11.2024)
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Journal Article
Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum
Stickles, Allison M, de Almeida, Mariana Justino, Morrisey, Joanne M, Sheridan, Kayla A, Forquer, Isaac P, Nilsen, Aaron, Winter, Rolf W, Burrows, Jeremy N, Fidock, David A, Vaidya, Akhil B, Riscoe, Michael K
Published in Antimicrobial agents and chemotherapy (01.04.2015)
Published in Antimicrobial agents and chemotherapy (01.04.2015)
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Journal Article
Open data in drug discovery and development: lessons from malaria
Wells, Timothy N. C., Willis, Paul, Burrows, Jeremy N., van Huijsduijnen, Rob Hooft
Published in Nature reviews. Drug discovery (01.10.2016)
Published in Nature reviews. Drug discovery (01.10.2016)
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Journal Article
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro
Walz, Annabelle, Duffey, Maëlle, Aljayyoussi, Ghaith, Sax, Sibylle, Leroy, Didier, Besson, Dominique, Burrows, Jeremy N, Cherkaoui-Rbati, Mohammed H, Gobeau, Nathalie, Westwood, Marie-Anne, Siethoff, Christoph, Gamo, Francisco-Javier, Mäser, Pascal, Wittlin, Sergio
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
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Journal Article
The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication
Policastro, Lucca R, Dolci, Isabela, Godoy, Andre S, Silva Júnior, José V J, Ruiz, Uriel E A, Santos, Igor A, Jardim, Ana C G, Samby, Kirandeep, Burrows, Jeremy N, Wells, Timothy N C, Gil, Laura H V G, Oliva, Glaucius, Fernandes, Rafaela S
Published in Viruses (21.06.2022)
Published in Viruses (21.06.2022)
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Journal Article
Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity
Cross, R. Matthew, Monastyrskyi, Andrii, Mutka, Tina S, Burrows, Jeremy N, Kyle, Dennis E, Manetsch, Roman
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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