The open access malaria box: a drug discovery catalyst for neglected diseases
Spangenberg, Thomas, Burrows, Jeremy N, Kowalczyk, Paul, McDonald, Simon, Wells, Timothy N C, Willis, Paul
Published in PloS one (17.06.2013)
Published in PloS one (17.06.2013)
Get full text
Journal Article
Hit and lead criteria in drug discovery for infectious diseases of the developing world
Katsuno, Kei, Burrows, Jeremy N., Duncan, Ken, van Huijsduijnen, Rob Hooft, Kaneko, Takushi, Kita, Kiyoshi, Mowbray, Charles E., Schmatz, Dennis, Warner, Peter, Slingsby, B. T.
Published in Nature reviews. Drug discovery (01.11.2015)
Published in Nature reviews. Drug discovery (01.11.2015)
Get full text
Journal Article
The state of the art in anti-malarial drug discovery and development
Burrows, Jeremy N, Chibale, Kelly, Wells, Timothy N C
Published in Current topics in medicinal chemistry (01.05.2011)
Published in Current topics in medicinal chemistry (01.05.2011)
Get more information
Journal Article
New developments in anti-malarial target candidate and product profiles
Burrows, Jeremy N, Duparc, Stephan, Gutteridge, Winston E, Hooft van Huijsduijnen, Rob, Kaszubska, Wiweka, Macintyre, Fiona, Mazzuri, Sébastien, Möhrle, Jörg J, Wells, Timothy N C
Published in Malaria journal (13.01.2017)
Published in Malaria journal (13.01.2017)
Get full text
Journal Article
Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors
Deng, Xiaoyi, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, Burrows, Jeremy N, Kaminsky, Werner, Charman, Susan A, Matthews, David, Rathod, Pradipsinh K, Phillips, Margaret A
Published in Journal of medicinal chemistry (26.06.2014)
Published in Journal of medicinal chemistry (26.06.2014)
Get full text
Journal Article
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis
Doggett, J. Stone, Nilsen, Aaron, Forquer, Isaac, Wegmann, Keith W, Jones-Brando, Lorraine, Yolken, Robert H, Bordón, Claudia, Charman, Susan A, Katneni, Kasiram, Schultz, Tracey, Burrows, Jeremy N, Hinrichs, David J, Meunier, Brigitte, Carruthers, Vern B, Riscoe, Michael K
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2012)
Get full text
Journal Article
Oxidative stress changes the effectiveness of artemisinin in Plasmodium falciparum
Pires, Camilla Valente, Cassandra, Debora, Xu, Shulin, Laleu, Benoit, Burrows, Jeremy N, Adams, John H
Published in mBio (13.03.2024)
Published in mBio (13.03.2024)
Get full text
Journal Article
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
Xie, Stanley C, Gillett, David L, Spillman, Natalie J, Tsu, Christopher, Luth, Madeline R, Ottilie, Sabine, Duffy, Sandra, Gould, Alexandra E, Hales, Paul, Seager, Benjamin A, Charron, Carlie L, Bruzzese, Frank, Yang, Xiaofeng, Zhao, Xiansi, Huang, Shih-Chung, Hutton, Craig A, Burrows, Jeremy N, Winzeler, Elizabeth A, Avery, Vicky M, Dick, Lawrence R, Tilley, Leann
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
Get full text
Journal Article
Actives from MMV Open Access Boxes? A suggested way forward
Samby, Kirandeep, Willis, Paul A, Burrows, Jeremy N, Laleu, Benoît, Webborn, Peter J H
Published in PLoS pathogens (01.04.2021)
Published in PLoS pathogens (01.04.2021)
Get full text
Journal Article
P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action
Sanz, Laura M, Crespo, Benigno, De-Cózar, Cristina, Ding, Xavier C, Llergo, Jose L, Burrows, Jeremy N, García-Bustos, Jose F, Gamo, Francisco-Javier
Published in PloS one (23.02.2012)
Published in PloS one (23.02.2012)
Get full text
Journal Article
An in vitro toolbox to accelerate anti-malarial drug discovery and development
Charman, Susan A, Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C K, Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M, White, Karen L, Almond, Lisa, Dickins, Maurice, Smith, Dennis A, Moehrle, Joerg J, Burrows, Jeremy N, Abla, Nada
Published in Malaria journal (02.01.2020)
Published in Malaria journal (02.01.2020)
Get full text
Journal Article
The global pipeline of new medicines for the control and elimination of malaria
Anthony, Melinda P, Burrows, Jeremy N, Duparc, Stephan, Moehrle, Joerg J, Wells, Timothy N C
Published in Malaria journal (07.09.2012)
Published in Malaria journal (07.09.2012)
Get full text
Journal Article
Discovery, Synthesis, and Optimization of Antimalarial 4(1H)‑Quinolone-3-Diarylethers
Nilsen, Aaron, Miley, Galen P, Forquer, Isaac P, Mather, Michael W, Katneni, Kasiram, Li, Yuexin, Pou, Sovitj, Pershing, April M, Stickles, Allison M, Ryan, Eileen, Kelly, Jane Xu, Doggett, J. Stone, White, Karen L, Hinrichs, David J, Winter, Rolf W, Charman, Susan A, Zakharov, Lev N, Bathurst, Ian, Burrows, Jeremy N, Vaidya, Akhil B, Riscoe, Michael K
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
Get full text
Journal Article
Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity
Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
Get full text
Journal Article
Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria
Macintyre, Fiona, Ramachandruni, Hanu, Burrows, Jeremy N, Holm, René, Thomas, Anna, Möhrle, Jörg J, Duparc, Stephan, Hooft van Huijsduijnen, Rob, Greenwood, Brian, Gutteridge, Winston E, Wells, Timothy N C, Kaszubska, Wiweka
Published in Malaria journal (01.11.2018)
Published in Malaria journal (01.11.2018)
Get full text
Journal Article
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro
Walz, Annabelle, Duffey, Maëlle, Aljayyoussi, Ghaith, Sax, Sibylle, Leroy, Didier, Besson, Dominique, Burrows, Jeremy N, Cherkaoui-Rbati, Mohammed H, Gobeau, Nathalie, Westwood, Marie-Anne, Siethoff, Christoph, Gamo, Francisco-Javier, Mäser, Pascal, Wittlin, Sergio
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
Published in Pharmaceuticals (Basel, Switzerland) (23.01.2023)
Get full text
Journal Article
Protein target similarity is positive predictor of in vitro antipathogenic activity: a drug repurposing strategy for Plasmodium falciparum
Mogire, Reagan M., Miruka, Silviane A., Juma, Dennis W., McNamara, Case W., Andagalu, Ben, Burrows, Jeremy N., Chenu, Elodie, Duffy, James, Ogutu, Bernhards R., Akala, Hoseah M.
Published in Journal of cheminformatics (30.05.2024)
Published in Journal of cheminformatics (30.05.2024)
Get full text
Journal Article
Development and application of a PBPK modeling strategy to support antimalarial drug development
Abla, Nada, Howgate, Eleanor, Rowland‐Yeo, Karen, Dickins, Maurice, Bergagnini‐Kolev, Mackenzie C., Chen, Kuan‐Fu, McFeely, Savannah, Bonner, Jennifer J., Santos, Laura G. A., Gobeau, Nathalie, Burt, Howard, Barter, Zoe, Jones, Hannah M., Wesche, David, Charman, Susan A., Möhrle, Jörg J., Burrows, Jeremy N., Almond, Lisa M.
Published in CPT: pharmacometrics and systems pharmacology (01.09.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.09.2023)
Get full text
Journal Article