TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Balka, Katherine R., Louis, Cynthia, Saunders, Tahnee L., Smith, Amber M., Calleja, Dale J., D’Silva, Damian B., Moghaddas, Fiona, Tailler, Maximilien, Lawlor, Kate E., Zhan, Yifan, Burns, Christopher J., Wicks, Ian P., Miner, Jonathan J., Kile, Benjamin T., Masters, Seth L., De Nardo, Dominic
Published in Cell reports (Cambridge) (07.04.2020)
Published in Cell reports (Cambridge) (07.04.2020)
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Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents
Asshoff, Malte, Petzer, Verena, Warr, Matthew R., Haschka, David, Tymoszuk, Piotr, Demetz, Egon, Seifert, Markus, Posch, Wilfried, Nairz, Manfred, Maciejewski, Pat, Fowles, Peter, Burns, Christopher J., Smith, Gregg, Wagner, Kay-Uwe, Weiss, Guenter, Whitney, J.Andrew, Theurl, Igor
Published in Blood (30.03.2017)
Published in Blood (30.03.2017)
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Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
Vaillant, François, Merino, Delphine, Lee, Lily, Breslin, Kelsey, Pal, Bhupinder, Ritchie, Matthew E., Smyth, Gordon K., Christie, Michael, Phillipson, Louisa J., Burns, Christopher J., Mann, G. Bruce, Visvader, Jane E., Lindeman, Geoffrey J.
Published in Cancer cell (08.07.2013)
Published in Cancer cell (08.07.2013)
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Journal Article
BET bromodomain inhibitors: a patent review
Garnier, Jean-Marc, Sharp, Phillip P, Burns, Christopher J
Published in Expert opinion on therapeutic patents (01.02.2014)
Published in Expert opinion on therapeutic patents (01.02.2014)
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Journal Article
Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden
Abubaker, Khalid, Luwor, Rodney B, Zhu, Hongjian, McNally, Orla, Quinn, Michael A, Burns, Christopher J, Thompson, Erik W, Findlay, Jock K, Ahmed, Nuzhat
Published in BMC cancer (06.05.2014)
Published in BMC cancer (06.05.2014)
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Journal Article
Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1
Patel, Onisha, Dai, Weiwen, Mentzel, Mareike, Griffin, Michael D.W., Serindoux, Juliette, Gay, Yoann, Fischer, Stefanie, Sterle, Shoukat, Kropp, Ashleigh, Burns, Christopher J., Ernst, Matthias, Buchert, Michael, Lucet, Isabelle S.
Published in Structure (London) (06.09.2016)
Published in Structure (London) (06.09.2016)
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CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms
Tyner, Jeffrey W., Bumm, Thomas G., Deininger, Jutta, Wood, Lisa, Aichberger, Karl J., Loriaux, Marc M., Druker, Brian J., Burns, Christopher J., Fantino, Emmanuelle, Deininger, Michael W.
Published in Blood (24.06.2010)
Published in Blood (24.06.2010)
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Journal Article
Therapeutic Effects of a TANK‐Binding Kinase 1 Inhibitor in Germinal Center–Driven Collagen‐Induced Arthritis
Louis, Cynthia, Ngo, Devi, D'Silva, Damian B., Hansen, Jacinta, Phillipson, Louisa, Jousset, Helene, Novello, Patrizia, Segal, David, Lawlor, Kate E., Burns, Christopher J., Wicks, Ian P.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.01.2019)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.01.2019)
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Journal Article
A constricted opening in Kir channels does not impede potassium conduction
Black, Katrina A, He, Sitong, Jin, Ruitao, Miller, David M, Bolla, Jani R, Clarke, Oliver B, Johnson, Paul, Windley, Monique, Burns, Christopher J, Hill, Adam P, Laver, Derek, Robinson, Carol V, Smith, Brian J, Gulbis, Jacqueline M
Published in Nature communications (15.06.2020)
Published in Nature communications (15.06.2020)
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Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma
Weeden, Clare E, Holik, Aliaksei Z, Young, Richard J, Ma, Stephen B, Garnier, Jean-Marc, Fox, Stephen B, Antippa, Phillip, Irving, Louis B, Steinfort, Daniel P, Wright, Gavin M, Russell, Prudence A, Ritchie, Matthew E, Burns, Christopher J, Solomon, Benjamin, Asselin-Labat, Marie-Liesse
Published in Molecular cancer therapeutics (01.08.2017)
Published in Molecular cancer therapeutics (01.08.2017)
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Journal Article
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
Lucet, Isabelle S., Fantino, Emmanuelle, Styles, Michelle, Bamert, Rebecca, Patel, Onisha, Broughton, Sophie E., Walter, Mark, Burns, Christopher J., Treutlein, Herbert, Wilks, Andrew F., Rossjohn, Jamie
Published in Blood (01.01.2006)
Published in Blood (01.01.2006)
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Journal Article
HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo
Lilja, Andrew, Weeden, Clare E, McArthur, Kate, Nguyen, Thao, Donald, Alastair, Wong, Zi Xin, Dousha, Lovisa, Bozinovski, Steve, Vlahos, Ross, Burns, Christopher J, Asselin-Labat, Marie-Liesse, Anderson, Gary P
Published in PloS one (23.01.2015)
Published in PloS one (23.01.2015)
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Journal Article
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages
Irvine, Katharine M., Andrews, Melanie R., Fernandez‐Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A., Sweet, Matthew J.
Published in Journal of leukocyte biology (01.02.2009)
Published in Journal of leukocyte biology (01.02.2009)
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Journal Article
Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors
Sharp, Phillip P, Garnier, Jean-Marc, Hatfaludi, Tamas, Xu, Zhen, Segal, David, Jarman, Kate E, Jousset, Hélène, Garnham, Alexandra, Feutrill, John T, Cuzzupe, Anthony, Hall, Peter, Taylor, Scott, Walkley, Carl R, Tyler, Dean, Dawson, Mark A, Czabotar, Peter, Wilks, Andrew F, Glaser, Stefan, Huang, David C. S, Burns, Christopher J
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Journal Article
Prevalence and impact of late defecation in the critically ill, thermally injured adult patient
Trexler, Scott T, Lundy, Jonathan B, Chung, Kevin K, Nitzschke, Stephanie L, Burns, Christopher J, Shields, Beth A, Cancio, Leopoldo C
Published in Journal of burn care & research (01.07.2014)
Published in Journal of burn care & research (01.07.2014)
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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
Liu, Bin, Trout, Robert E. Lee, Chu, Guo-Hua, McGarry, Daniel, Jackson, Randy W, Hamrick, Jodie C, Daigle, Denis M, Cusick, Susan M, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Docquier, Jean-Denis, Weiss, William J, Pevear, Daniel C, Xerri, Luigi, Burns, Christopher J
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa
Hamrick, Jodie C, Docquier, Jean-Denis, Uehara, Tsuyoshi, Myers, Cullen L, Six, David A, Chatwin, Cassandra L, John, Kaitlyn J, Vernacchio, Salvador F, Cusick, Susan M, Trout, Robert E L, Pozzi, Cecilia, De Luca, Filomena, Benvenuti, Manuela, Mangani, Stefano, Liu, Bin, Jackson, Randy W, Moeck, Greg, Xerri, Luigi, Burns, Christopher J, Pevear, Daniel C, Daigle, Denis M
Published in Antimicrobial agents and chemotherapy (21.02.2020)
Published in Antimicrobial agents and chemotherapy (21.02.2020)
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CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo
Burns, Christopher J, Fantino, Emmanuelle, Phillips, Ian D, Su, Stephen, Harte, Michael F, Bukczynska, Patricia E, Frazzetto, Mark, Joffe, Max, Kruszelnicki, Irma, Wang, Bing, Wang, Yue, Wilson, Neil, Dilley, Rodney J, Wan, Soo S, Charman, Susan A, Shackleford, David M, Fida, Rosa, Malcontenti-Wilson, Cathy, Wilks, Andrew F
Published in Molecular cancer therapeutics (01.11.2009)
Published in Molecular cancer therapeutics (01.11.2009)
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