Estimating the potential for optimized curb management to reduce delivery vehicle double parking, traffic congestion and energy consumption
Burns, Aaron J., Michalek, Jeremy J., Samaras, Constantine
Published in Transportation research. Part E, Logistics and transportation review (01.07.2024)
Published in Transportation research. Part E, Logistics and transportation review (01.07.2024)
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Journal Article
C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase
Gui, Jinghan, Zhou, Qianghui, Pan, Chung-Mao, Yabe, Yuki, Burns, Aaron C, Collins, Michael R, Ornelas, Martha A, Ishihara, Yoshihiro, Baran, Phil S
Published in Journal of the American Chemical Society (02.04.2014)
Published in Journal of the American Chemical Society (02.04.2014)
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Journal Article
Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer
Sabari, Joshua K, Velcheti, Vamsidhar, Shimizu, Kazuhide, Strickland, Matthew R, Heist, Rebecca S, Singh, Mohini, Nayyar, Naema, Giobbie-Hurder, Anita, Digumarthy, Subba R, Gainor, Justin F, Rajan, Anant P, Nieblas-Bedolla, Edwin, Burns, Aaron C, Hallin, Jill, Olson, Peter, Christensen, James G, Kurz, Sylvia C, Brastianos, Priscilla K, Wakimoto, Hiroaki
Published in Clinical cancer research (02.08.2022)
Published in Clinical cancer research (02.08.2022)
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Journal Article
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
Smith, Christopher R, Aranda, Ruth, Bobinski, Thomas P, Briere, David M, Burns, Aaron C, Christensen, James G, Clarine, Jeffery, Engstrom, Lars D, Gunn, Robin J, Ivetac, Anthony, Jean-Baptiste, Ronald, Ketcham, John M, Kobayashi, Masakazu, Kuehler, Jon, Kulyk, Svitlana, Lawson, J. David, Moya, Krystal, Olson, Peter, Rahbaek, Lisa, Thomas, Nicole C, Wang, Xiaolun, Waters, Laura M, Marx, Matthew A
Published in Journal of medicinal chemistry (10.02.2022)
Published in Journal of medicinal chemistry (10.02.2022)
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Journal Article
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction
Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.
Published in Journal of medicinal chemistry (28.07.2022)
Published in Journal of medicinal chemistry (28.07.2022)
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Journal Article
Total Synthesis of (−)-Salvinorin A
Line, Nathan J., Burns, Aaron C., Butler, Sean C., Casbohm, Jerry, Forsyth, Craig J.
Published in Chemistry : a European journal (12.12.2016)
Published in Chemistry : a European journal (12.12.2016)
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Journal Article
Solvent-Controlled, Site-Selective N‑Alkylation Reactions of Azolo-Fused Ring Heterocycles at N1‑, N2‑, and N3-Positions, Including Pyrazolo[3,4‑d]pyrimidines, Purines, [1,2,3]Triazolo[4,5]pyridines, and Related Deaza-Compounds
Bookser, Brett C, Weinhouse, Michael I, Burns, Aaron C, Valiere, Andrew N, Valdez, Lino J, Stanczak, Pawel, Na, Jim, Rheingold, Arnold L, Moore, Curtis E, Dyck, Brian
Published in Journal of organic chemistry (15.06.2018)
Published in Journal of organic chemistry (15.06.2018)
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Journal Article
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein
Ketcham, John M., Harwood, Stephen J., Aranda, Ruth, Aloiau, Athenea N., Bobek, Briana M., Briere, David M., Burns, Aaron C., Caddell Haatveit, Kersti, Calinisan, Andrew, Clarine, Jeffery, Elliott, Adam, Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Jones, Benjamin, Kuehler, Jon, Lawson, J. David, Nguyen, Natalie, Parker, Cody, Pearson, Kelly E., Rahbaek, Lisa, Saechao, Barbara, Wang, Xiaolun, Waters, Anna, Waters, Laura, Watkins, Ashlee H., Olson, Peter, Smith, Christopher R., Christensen, James G., Marx, Matthew A.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Journal Article
A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes
O’Hara, Fionn, Burns, Aaron C, Collins, Michael R, Dalvie, Deepak, Ornelas, Martha A, Vaz, Alfin D. N, Fujiwara, Yuta, Baran, Phil S
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer
Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Fell, Jay B, Fischer, John P, Baer, Brian R, Blake, James F, Bouhana, Karyn, Briere, David M, Brown, Karin D, Burgess, Laurence E, Burns, Aaron C, Burkard, Michael R, Chiang, Harrah, Chicarelli, Mark J, Cook, Adam W, Gaudino, John J, Hallin, Jill, Hanson, Lauren, Hartley, Dylan P, Hicken, Erik J, Hingorani, Gary P, Hinklin, Ronald J, Mejia, Macedonio J, Olson, Peter, Otten, Jennifer N, Rhodes, Susan P, Rodriguez, Martha E, Savechenkov, Pavel, Smith, Darin J, Sudhakar, Niranjan, Sullivan, Francis X, Tang, Tony P, Vigers, Guy P, Wollenberg, Lance, Christensen, James G, Marx, Matthew A
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Simple Sulfinate Synthesis Enables CH Trifluoromethylcyclopropanation
Gianatassio, Ryan, Kawamura, Shuhei, Eprile, Cecil L, Foo, Klement, Ge, Jason, Burns, Aaron C., Collins, Michael R., Baran, Phil S.
Published in Angewandte Chemie (08.09.2014)
Published in Angewandte Chemie (08.09.2014)
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Journal Article