Clinicogenomic Analysis of FGFR2 -Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib
Silverman, Ian M, Hollebecque, Antoine, Friboulet, Luc, Owens, Sherry, Newton, Robert C, Zhen, Huiling, Féliz, Luis, Zecchetto, Camilla, Melisi, Davide, Burn, Timothy C
Published in Cancer discovery (01.02.2021)
Published in Cancer discovery (01.02.2021)
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INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models
Liu, Phillip C C, Koblish, Holly, Wu, Liangxing, Bowman, Kevin, Diamond, Sharon, DiMatteo, Darlise, Zhang, Yue, Hansbury, Michael, Rupar, Mark, Wen, Xiaoming, Collier, Paul, Feldman, Patricia, Klabe, Ronald, Burke, Krista A, Soloviev, Maxim, Gardiner, Christine, He, Xin, Volgina, Alla, Covington, Maryanne, Ruggeri, Bruce, Wynn, Richard, Burn, Timothy C, Scherle, Peggy, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Hollis, Gregory
Published in PloS one (21.04.2020)
Published in PloS one (21.04.2020)
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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Yue, Eddy W, Sparks, Richard, Polam, Padmaja, Modi, Dilip, Douty, Brent, Wayland, Brian, Glass, Brian, Takvorian, Amy, Glenn, Joseph, Zhu, Wenyu, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J, Hansbury, Michael J, Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Koblish, Holly K, Fridman, Jordan S, Emm, Tom, Scherle, Peggy A, Metcalf, Brian, Combs, Andrew P
Published in ACS medicinal chemistry letters (11.05.2017)
Published in ACS medicinal chemistry letters (11.05.2017)
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Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
Liu, Xiangdong, Shin, Niu, Koblish, Holly K., Yang, Gengjie, Wang, Qian, Wang, Kathy, Leffet, Lynn, Hansbury, Michael J., Thomas, Beth, Rupar, Mark, Waeltz, Paul, Bowman, Kevin J., Polam, Padmaja, Sparks, Richard B., Yue, Eddy W., Li, Yanlong, Wynn, Richard, Fridman, Jordan S., Burn, Timothy C., Combs, Andrew P., Newton, Robert C., Scherle, Peggy A.
Published in Blood (29.04.2010)
Published in Blood (29.04.2010)
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Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis
Mascarenhas, John O, Talpaz, Moshe, Gupta, Vikas, Foltz, Lynda M, Savona, Michael R, Paquette, Ronald, Turner, A Robert, Coughlin, Paul, Winton, Elliott, Burn, Timothy C, O'Neill, Peter, Clark, Jason, Hunter, Deborah, Assad, Albert, Hoffman, Ronald, Verstovsek, Srdan
Published in Haematologica (Roma) (01.02.2017)
Published in Haematologica (Roma) (01.02.2017)
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Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
Fridman, Jordan S, Scherle, Peggy A, Collins, Robert, Burn, Timothy C, Li, Yanlong, Li, Jun, Covington, Maryanne B, Thomas, Beth, Collier, Paul, Favata, Margaret F, Wen, Xiaoming, Shi, Jack, McGee, Ryan, Haley, Patrick J, Shepard, Stacey, Rodgers, James D, Yeleswaram, Swamy, Hollis, Greg, Newton, Robert C, Metcalf, Brian, Friedman, Steven M, Vaddi, Kris
Published in The Journal of immunology (1950) (01.05.2010)
Published in The Journal of immunology (1950) (01.05.2010)
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Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors
Koblish, Holly K, Hansbury, Michael J, Bowman, Kevin J, Yang, Gengjie, Neilan, Claire L, Haley, Patrick J, Burn, Timothy C, Waeltz, Paul, Sparks, Richard B, Yue, Eddy W, Combs, Andrew P, Scherle, Peggy A, Vaddi, Kris, Fridman, Jordan S
Published in Molecular cancer therapeutics (01.02.2010)
Published in Molecular cancer therapeutics (01.02.2010)
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Global Expanded Access Program for Pemigatinib in Patients with Previously Treated Locally Advanced or Metastatic Cholangiocarcinoma and Fibroblast Growth Factor Receptor Gene Alterations
Lindley, Anouk, Prager, Gerald, Bitzer, Michael, Burn, Timothy C, Lihou, Christine F, Croft, Elisabeth
Published in Cancer research and treatment (01.07.2024)
Published in Cancer research and treatment (01.07.2024)
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The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis
Deininger, Michael, Radich, Jerald, Burn, Timothy C., Huber, Reid, Paranagama, Dilan, Verstovsek, Srdan
Published in Blood (24.09.2015)
Published in Blood (24.09.2015)
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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells
Liu, Phillip C.C., Liu, Xiangdong, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Huber, Reid, Hillman, Milton, Yang, Gengjie, Ellis, Dawn, Marando, Cindy, Katiyar, Kamna, Bradley, Jodi, Abremski, Kenneth, Stow, Mark, Rupar, Mark, Zhuo, Jincong, Li, Yun-Long, Lin, Qiyan, Burns, David, Xu, Meizhong, Zhang, Colin, Qian, Ding-Quan, He, Chunhong, Sharief, Vaqar, Weng, Lingkai, Agrios, Costas, Shi, Eric, Metcalf, Brian, Newton, Robert, Friedman, Steven, Yao, Wenqing, Scherle, Peggy A., Hollis, Gregory, Burn, Timothy C.
Published in Cancer biology & therapy (01.06.2006)
Published in Cancer biology & therapy (01.06.2006)
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Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
Ala, Paul J., Gonneville, Lucie, Hillman, Milton C., Becker-Pasha, Mary, Wei, Min, Reid, Brian G., Klabe, Ronald, Yue, Eddy W., Wayland, Brian, Douty, Brent, Polam, Padmaja, Wasserman, Zelda, Bower, Michael, Combs, Andrew P., Burn, Timothy C., Hollis, Gregory F., Wynn, Richard
Published in The Journal of biological chemistry (27.10.2006)
Published in The Journal of biological chemistry (27.10.2006)
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Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines
Douty, Brent, Wayland, Brian, Ala, Paul J., Bower, Michael J., Pruitt, James, Bostrom, Lori, Wei, Min, Klabe, Ronald, Gonneville, Lucie, Wynn, Richard, Burn, Timothy C., Liu, Phillip C.C., Combs, Andrew P., Yue, Eddy W.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Structural Insights into the Design of Nonpeptidic Isothiazolidinone-containing Inhibitors of Protein-tyrosine Phosphatase 1B
Ala, Paul J., Gonneville, Lucie, Hillman, Milton, Becker-Pasha, Mary, Yue, Eddy W., Douty, Brent, Wayland, Brian, Polam, Padmaja, Crawley, Matthew L., McLaughlin, Erin, Sparks, Richard B., Glass, Brian, Takvorian, Amy, Combs, Andrew P., Burn, Timothy C., Hollis, Gregory F., Wynn, Richard
Published in The Journal of biological chemistry (08.12.2006)
Published in The Journal of biological chemistry (08.12.2006)
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Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters
Huber, Reid M, Murphy, Kathleen, Miao, Bowman, Link, John R, Cunningham, Mark R, Rupar, Mark J, Gunyuzlu, Paul L, Haws, Thomas F, Kassam, Altaf, Powell, Francoise, Hollis, Gregory F, Young, Peter R, Mukherjee, Ranjan, Burn, Timothy C
Published in Gene (15.05.2002)
Published in Gene (15.05.2002)
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Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor
Wu, Liangxing, Zhang, Colin, He, Chunhong, Qian, Dingquan, Lu, Liang, Sun, Yaping, Xu, Meizhong, Zhuo, Jincong, Liu, Phillip C. C, Klabe, Ronald, Wynn, Richard, Covington, Maryanne, Gallagher, Karen, Leffet, Lynn, Bowman, Kevin, Diamond, Sharon, Koblish, Holly, Zhang, Yue, Soloviev, Maxim, Hollis, Gregory, Burn, Timothy C, Scherle, Peggy, Yeleswaram, Swamy, Huber, Reid, Yao, Wenqing
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Genomic architecture of FGFR2 fusions in cholangiocarcinoma and its implication for molecular testing
Neumann, Olaf, Burn, Timothy C., Allgäuer, Michael, Ball, Markus, Kirchner, Martina, Albrecht, Thomas, Volckmar, Anna-Lena, Beck, Susanne, Endris, Volker, Goldschmid, Hannah, Lehmann, Ulrich, Seker-Cin, Huriye, Uhrig, Sebastian, Roessler, Stephanie, Budczies, Jan, Fröhling, Stefan, Longerich, Thomas, Wagner, Alex H., Vogel, Arndt, Schirmacher, Peter, Stenzinger, Albrecht, Kazdal, Daniel
Published in British journal of cancer (01.11.2022)
Published in British journal of cancer (01.11.2022)
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Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Liu, Phillip C C, Caulder, Eian, Li, Jun, Waeltz, Paul, Margulis, Alex, Wynn, Richard, Becker-Pasha, Mary, Li, Yanlong, Crowgey, Erin, Hollis, Gregory, Haley, Patrick, Sparks, Richard B, Combs, Andrew P, Rodgers, James D, Burn, Timothy C, Vaddi, Kris, Fridman, Jordan S
Published in Clinical cancer research (15.11.2009)
Published in Clinical cancer research (15.11.2009)
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Truncated FGFR2 is a clinically actionable oncogene in multiple cancers
Zingg, Daniel, Bhin, Jinhyuk, Yemelyanenko, Julia, Kas, Sjors M., Rolfs, Frank, Lutz, Catrin, Lee, Jessica K., Klarenbeek, Sjoerd, Silverman, Ian M., Annunziato, Stefano, Chan, Chang S., Piersma, Sander R., Eijkman, Timo, Badoux, Madelon, Gogola, Ewa, Siteur, Bjørn, Sprengers, Justin, de Klein, Bim, de Goeij-de Haas, Richard R., Riedlinger, Gregory M., Ke, Hua, Madison, Russell, Drenth, Anne Paulien, van der Burg, Eline, Schut, Eva, Henneman, Linda, van Miltenburg, Martine H., Proost, Natalie, Zhen, Huiling, Wientjens, Ellen, de Bruijn, Roebi, de Ruiter, Julian R., Boon, Ute, de Korte-Grimmerink, Renske, van Gerwen, Bastiaan, Féliz, Luis, Abou-Alfa, Ghassan K., Ross, Jeffrey S., van de Ven, Marieke, Rottenberg, Sven, Cuppen, Edwin, Chessex, Anne Vaslin, Ali, Siraj M., Burn, Timothy C., Jimenez, Connie R., Ganesan, Shridar, Wessels, Lodewyk F. A., Jonkers, Jos
Published in Nature (London) (18.08.2022)
Published in Nature (London) (18.08.2022)
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Ruxolitinib reduces JAK2 p.V617F allele burden in patients with polycythemia vera enrolled in the RESPONSE study
Vannucchi, Alessandro Maria, Verstovsek, Srdan, Guglielmelli, Paola, Griesshammer, Martin, Burn, Timothy C., Naim, Ahmad, Paranagama, Dilan, Marker, Mahtab, Gadbaw, Brian, Kiladjian, Jean-Jacques
Published in Annals of hematology (01.07.2017)
Published in Annals of hematology (01.07.2017)
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Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model
Yue, Eddy W, Douty, Brent, Wayland, Brian, Bower, Michael, Liu, Xiangdong, Leffet, Lynn, Wang, Qian, Bowman, Kevin J, Hansbury, Michael J, Liu, Changnian, Wei, Min, Li, Yanlong, Wynn, Richard, Burn, Timothy C, Koblish, Holly K, Fridman, Jordan S, Metcalf, Brian, Scherle, Peggy A, Combs, Andrew P
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
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