Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma
Barone, Tara A, Burkhart, Catherine A, Safina, Alfiya, Haderski, Gary, Gurova, Katerina V, Purmal, Andrei A, Gudkov, Andrei V, Plunkett, Robert J
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2017)
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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT
Gasparian, Alexander V, Burkhart, Catherine A, Purmal, Andrei A, Brodsky, Leonid, Pal, Mahadeb, Saranadasa, Madhi, Bosykh, Dmitry A, Commane, Mairead, Guryanova, Olga A, Pal, Srabani, Safina, Alfiya, Sviridov, Sergey, Koman, Igor E, Veith, Jean, Komar, Anton A, Gudkov, Andrei V, Gurova, Katerina V
Published in Science translational medicine (10.08.2011)
Published in Science translational medicine (10.08.2011)
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Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas
Kim, Minhyung, Neznanov, Nickolay, Wilfong, Chandler D, Fleyshman, Daria I, Purmal, Andrei A, Haderski, Gary, Stanhope-Baker, Patricia, Burkhart, Catherine A, Gurova, Katerina V, Gudkov, Andrei V, Skitzki, Joseph J
Published in Cancer research (Chicago, Ill.) (15.11.2016)
Published in Cancer research (Chicago, Ill.) (15.11.2016)
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Small-Molecule Multidrug Resistance―Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma
BURKHART, Catherine A, WATT, Fujiko, KOMAROV, Pavel G, GUROVA, Katerina V, SARTORELLI, Alan C, MARSHALL, Glenn M, NORRIS, Murray D, GUDKOV, Andrei V, HABER, Michelle, MURRAY, Jayne, PAJIC, Marina, PROKVOLIT, Anatoly, CHENGYUAN XUE, FLEMMING, Claudia, SMITH, Janice, PURMAL, Andrei, ISACHENKO, Nadezhda
Published in Cancer research (Chicago, Ill.) (15.08.2009)
Published in Cancer research (Chicago, Ill.) (15.08.2009)
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TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells
Leonova, Katerina, Safina, Alfiya, Nesher, Elimelech, Sandlesh, Poorva, Pratt, Rachel, Burkhart, Catherine, Lipchick, Brittany, Gitlin, Ilya, Frangou, Costakis, Koman, Igor, Wang, Jianmin, Kirsanov, Kirill, Yakubovskaya, Marianna G, Gudkov, Andrei V, Gurova, Katerina
Published in eLife (05.02.2018)
Published in eLife (05.02.2018)
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A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications
Mett, Vadim, Kurnasov, Oleg V., Bespalov, Ivan A., Molodtsov, Ivan, Brackett, Craig M., Burdelya, Lyudmila G., Purmal, Andrei A., Gleiberman, Anatoli S., Toshkov, Ilia A., Burkhart, Catherine A., Kogan, Yakov N., Andrianova, Ekaterina L., Gudkov, Andrei V., Osterman, Andrei L.
Published in Communications biology (12.04.2021)
Published in Communications biology (12.04.2021)
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Mechanisms of Embryonal Tumor Initiation: Distinct Roles for MycN Expression and MYCN Amplification
Hansford, Loen M., Thomas, Wayne D., Keating, Joanna M., Burkhart, Catherine A., Peaston, Anne E., Norris, Murray D., Haber, Michelle, Armati, Patricia J., Weiss, William A., Marshall, Glenn M., Cavenee, Webster K.
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2004)
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N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma
FLETCHER, Jamie I, GHERARDI, Samuele, MARSHALL, Glenn M, NORRIS, Murray D, PERINI, Giovanni, HABER, Michelle, MURRAY, Jayne, BURKHART, Catherine A, RUSSELL, Amanda, VALLI, Emanuele, SMITH, Janice, OBERTHUER, André, ASHTON, Lesley J, LONDON, Wendy B
Published in Cancer research (Chicago, Ill.) (15.02.2012)
Published in Cancer research (Chicago, Ill.) (15.02.2012)
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Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer
Burkhart, Catherine, Fleyshman, Daria, Kohrn, Rachael, Commane, Mairead, Garrigan, Jennifer, Kurbatov, Vadim, Toshkov, Ilya, Ramachandran, Rajesh, Martello, Laura, Gurova, Katerina V.
Published in Oncotarget (30.11.2014)
Published in Oncotarget (30.11.2014)
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Effects of MYCN Antisense Oligonucleotide Administration on Tumorigenesis in a Murine Model of Neuroblastoma
Burkhart, Catherine A., Cheng, Andy J., Madafiglio, Janice, Kavallaris, Maria, Mili, Mario, Marshall, Glenn M., Weiss, William A., Khachigian, Levon M., Norris, Murray D., Haber, Michelle
Published in JNCI : Journal of the National Cancer Institute (17.09.2003)
Published in JNCI : Journal of the National Cancer Institute (17.09.2003)
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Abstract 3878: Drug-loaded microparticles as a treatment approach for pancreatic cancer
Munoz-Sagastibelza, Maria, Okome, Oluwafeyikemi, Sanchez, Jenny E. Paredes, Palileo, Albert, Burkhart, Catherine, Martello-Rooney, Laura
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma
Carter, Daniel R, Murray, Jayne, Cheung, Belamy B, Gamble, Laura, Koach, Jessica, Tsang, Joanna, Sutton, Selina, Kalla, Heyam, Syed, Sarah, Gifford, Andrew J, Issaeva, Natalia, Biktasova, Asel, Atmadibrata, Bernard, Sun, Yuting, Sokolowski, Nicolas, Ling, Dora, Kim, Patrick Y, Webber, Hannah, Clark, Ashleigh, Ruhle, Michelle, Liu, Bing, Oberthuer, André, Fischer, Matthias, Byrne, Jennifer, Saletta, Federica, Thwe, Le Myo, Purmal, Andrei, Haderski, Gary, Burkhart, Catherine, Speleman, Frank, De Preter, Katleen, Beckers, Anneleen, Ziegler, David S, Liu, Tao, Gurova, Katerina V, Gudkov, Andrei V, Norris, Murray D, Haber, Michelle, Marshall, Glenn M
Published in Science translational medicine (04.11.2015)
Published in Science translational medicine (04.11.2015)
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Abstract 2616: A novel iron-chelating agent reduces MYC transcription via E2F gene family regulation
Valli, Emanuele, Xue, Chengyuan, Cheung, Leanna, Gamble, Laura, Pandher, Ruby, Giacomo, Simone Di, Burkhart, Catherine, Fedtsova, Natalia, Ferrucci, Francesca, Makarov, Sergei, Telfer, Thomas, Codd, Rachel, Scott, David, Perini, Giovanni, Osterman, Andrei, Gudkov, Andrei, Norris, Murray, Haber, Michelle
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 2070: Gemcitabine-loaded microparticles promote cancer cell death in subcutaneous pancreatic cancer xenografts
Munoz-Sagastibelza, Maria, Kurbatov, Vadim, Dynes, Sophia, Caceres, Jennifer, Chen, Michael, Gupta, Raavi, Burkhart, Catherine, Martello-Rooney, Laura
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 815: CBL0137 demonstrates significant antitumor activity against hepatocellular carcinoma alone and in combination with sorafenib
Burkhart, Catherine, Kohrn, Rachael, Walker, Brittany, Gurova, Katerina, Purmal, Andrei, Gudkov, Andrei
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract 800: Synergistic effects of CBL0137 and gemcitabine against non-small cell lung and pancreatic cancer xenografts
Burkhart, Catherine, Kohrn, Rachael, Walker, Brittany, Meyer, David, Gurova, Katerina, Gudkov, Andrei
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer
Burkhart, Catherine, Fleyshman, Daria, Kohrn, Rachael, Commane, Mairead, Garrigan, Jennifer, Kurbatov, Vadim, Toshkov, Ilya, Ramachandran, Rajesh, Martello, Laura, Gurova, Katerina V
Published in Oncotarget (30.11.2014)
Published in Oncotarget (30.11.2014)
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Curaxin Cbl0137 Demonstrates Significant Antitumor Activity Against Fact-Positive Patient-Derived Pancreatic Ductal Adenocarcinoma
Burkhart, Catherine, Paszkiewicz, Geraldine, Gawron, Loretta, Kohrn, Rachael, Purmal, Andrei, Repasky, Elizabeth, Morrison, Carl, Omilian, Angela, Gudkov, Andrei, Gurova, Katerina
Published in Annals of oncology (01.06.2013)
Published in Annals of oncology (01.06.2013)
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