Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib
Huang, Qinhua, Johnson, Ted W, Bailey, Simon, Brooun, Alexei, Bunker, Kevin D, Burke, Benjamin J, Collins, Michael R, Cook, Andrew S, Cui, J. Jean, Dack, Kevin N, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Johnson, Patrick S, Kania, Robert S, Lam, Hieu, Lam, Justine L, Le, Phuong T, Li, Qiuhua, Lingardo, Laura, Liu, Wei, Lu, Melissa West, McTigue, Michele, Palmer, Cynthia L, Richardson, Paul F, Sach, Neal W, Shen, Hong, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Tsaparikos, Konstantinos, Wang, Hui, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists
Guo, Chuangxing, Linton, Angelica, Kephart, Susan, Ornelas, Martha, Pairish, Mason, Gonzalez, Javier, Greasley, Samantha, Nagata, Asako, Burke, Benjamin J, Edwards, Martin, Hosea, Natilie, Kang, Ping, Hu, Wenyue, Engebretsen, Jon, Briere, David, Shi, Manli, Gukasyan, Hovik, Richardson, Paul, Dack, Kevin, Underwood, Toby, Johnson, Patrick, Morell, Andrew, Felstead, Robert, Kuruma, Hidetoshi, Matsimoto, Hiroaki, Zoubeidi, Amina, Gleave, Martin, Los, Gerrit, Fanjul, Andrea N
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F
Shaw, Alice T, Friboulet, Luc, Leshchiner, Ignaty, Gainor, Justin F, Bergqvist, Simon, Brooun, Alexei, Burke, Benjamin J, Deng, Ya-Li, Liu, Wei, Dardaei, Leila, Frias, Rosa L, Schultz, Kate R, Logan, Jennifer, James, Leonard P, Smeal, Tod, Timofeevski, Sergei, Katayama, Ryohei, Iafrate, A. John, Le, Long, McTigue, Michele, Getz, Gad, Johnson, Ted W, Engelman, Jeffrey A
Published in The New England journal of medicine (07.01.2016)
Published in The New England journal of medicine (07.01.2016)
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1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for ortho/meta-substituted arenes
Zhao, Jin-Xin, Chang, Yu-Xuan, He, Chi, Burke, Benjamin J., Collins, Michael R., Del Bel, Matthew, Elleraas, Jeff, Gallego, Gary M., Montgomery, T. Patrick, Mousseau, James J., Nair, Sajiv K., Perry, Matthew A., Spangler, Jillian E., Vantourout, Julien C., Baran, Phil S.
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2021)
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Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer
Yoda, Satoshi, Lin, Jessica J, Lawrence, Michael S, Burke, Benjamin J, Friboulet, Luc, Langenbucher, Adam, Dardaei, Leila, Prutisto-Chang, Kylie, Dagogo-Jack, Ibiayi, Timofeevski, Sergei, Hubbeling, Harper, Gainor, Justin F, Ferris, Lorin A, Riley, Amanda K, Kattermann, Krystina E, Timonina, Daria, Heist, Rebecca S, Iafrate, A John, Benes, Cyril H, Lennerz, Jochen K, Mino-Kenudson, Mari, Engelman, Jeffrey A, Johnson, Ted W, Hata, Aaron N, Shaw, Alice T
Published in Cancer discovery (01.06.2018)
Published in Cancer discovery (01.06.2018)
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Discovery of (10R)-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations
Johnson, Ted W., Richardson, Paul F., Bailey, Simon, Brooun, Alexei, Burke, Benjamin J., Collins, Michael R., Cui, J. Jean, Deal, Judith G., Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D., He, Mingying, Hoffman, Jacqui, Hoffman, Robert L., Huang, Qinhua, Kania, Robert S., Kath, John C., Lam, Hieu, Lam, Justine L., Le, Phuong T., Lingardo, Laura, Liu, Wei, McTigue, Michele, Palmer, Cynthia L., Sach, Neal W., Smeal, Tod, Smith, Graham L., Stewart, Albert E., Timofeevski, Sergei, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y., Edwards, Martin P.
Published in Journal of medicinal chemistry (12.06.2014)
Published in Journal of medicinal chemistry (12.06.2014)
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Development and Comprehensive Benchmark of a High-Quality AMBER-Consistent Small Molecule Force Field with Broad Chemical Space Coverage for Molecular Modeling and Free Energy Calculation
Xue, Bai, Yang, Qingyi, Zhang, Qiaochu, Wan, Xiao, Fang, Dong, Lin, Xiaolu, Sun, Guangxu, Gobbo, Gianpaolo, Cao, Fenglei, Mathiowetz, Alan M., Burke, Benjamin J., Kumpf, Robert A., Rai, Brajesh K., Wood, Geoffrey P. F., Pickard, Frank C., Wang, Junmei, Zhang, Peiyu, Ma, Jian, Jiang, Yide Alan, Wen, Shuhao, Hou, Xinjun, Zou, Junjie, Yang, Mingjun
Published in Journal of chemical theory and computation (23.01.2024)
Published in Journal of chemical theory and computation (23.01.2024)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1 Lactam Moieties as l-Glutamine Replacements
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Webber, Stephen E, Marakovits, Joseph T, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Ford, Clifford E, Burke, Benjamin J, Rejto, Paul A, Hendrickson, Thomas F, Tuntland, Tove, Brown, Edward L, Meador, James W, Ferre, Rose Ann, Harr, James E. V, Kosa, Maha B, Worland, Stephen T
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Characterization of Specific N-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library
Kung, Pei-Pei, Bingham, Patrick, Burke, Benjamin J., Chen, Qiuxia, Cheng, Xuemin, Deng, Ya-Li, Dou, Dengfeng, Feng, Junli, Gallego, Gary M., Gehring, Michael R., Grant, Stephan K., Greasley, Samantha, Harris, Anthony R., Maegley, Karen A., Meier, Jordan, Meng, Xiaoyun, Montano, Jose L., Morgan, Barry A., Naughton, Brigitte S., Palde, Prakash B., Paul, Thomas A., Richardson, Paul, Sakata, Sylvie, Shaginian, Alex, Sonnenburg, William K., Subramanyam, Chakrapani, Timofeevski, Sergei, Wan, Jinqiao, Yan, Wen, Stewart, Albert E.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Effect of water solvation on the lipophilicity of isomeric pyrimidine-carboxamides
Linton, Maria Angelica, Burke, Benjamin J., Johnson, Ted W., Ninkovic, Sacha, Gajiwala, Ketan S., Richardson, Paul, Le, Phuong T.
Published in Bioorganic & medicinal chemistry (01.07.2015)
Published in Bioorganic & medicinal chemistry (01.07.2015)
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Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)
Murphy, Sean T, Alton, Gordon, Bailey, Simon, Baxi, Sangita M, Burke, Benjamin J, Chappie, Thomas A, Ermolieff, Jacques, Ferre, RoseAnn, Greasley, Samantha, Hickey, Michael, Humphrey, John, Kablaoui, Natasha, Kath, John, Kazmirski, Steven, Kraus, Michelle, Kupchinsky, Stan, Li, John, Lingardo, Laura, Marx, Matthew A, Richter, Dan, Tanis, Steven P, Tran, Khanh, Vernier, William, Xie, Zhi, Yin, Min-Jean, Yu, Xiao-Hong
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
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Journal Article
1,2-Difunctionalized bicyclo1.1.1pentanes: Long-sought-after mimetics for ortho/meta-substituted arenes
Zhao, Jin-Xin, Chang, Yu-Xuan, He, Chi, Burke, Benjamin J, Collins, Michael R, Del Bel, Matthew, Elleraas, Jeff, Gallego, Gary M, Montgomery, T Patrick, Mousseau, James J, Nair, Sajiv K, Perry, Matthew A, Spangler, Jillian E, Vantourout, Julien C, Baran, Phil S
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (13.07.2021)
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Abstract LB028: Discovery and characterization of selective heterobifunctional degraders of EP300 in hematopoietic malignancies
Derheimer, Frederick A., Givarkes, Ninvita, Miller, Natalie, Grantner, Rita, Quinlan, Casey, Brun, Sonja, Paul, Thomas, Ruefli-Brasse, Astrid, Steyn, Stefan, Bartlett, Derek, Hayward, Matthew, Brown, Matthew, Uccello, Daniel, Burke, Benjamin J., Borzilleri, Kris, Gilbert, Adam, Hemkens, Michelle
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Construction of a molecular shape analysis: three-dimensional quantitative structure-activity relationship for an analog series of pyridobenzodiazepinone inhibitors of muscarinic 2 and 3 receptors
Burke, Benjamin J, Dunn, William J. III, Dunn, William J
Published in Journal of medicinal chemistry (01.10.1994)
Published in Journal of medicinal chemistry (01.10.1994)
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Abstract PR10: Is CNS availability for oncology a no-brainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations
Johnson, Ted W., Bailey, Simon, Burke, Benjamin J., Collins, Michael R., Cui, J. Jean, Deal, Judy, Deng, Ya-Li, Edwards, Martin P., He, Mingying, Hoffman, Jacqui, Hoffman, Robert L., Huang, Qinhua, Kania, Robert S., Le, Phuong, McTigue, Michele, Palmer, Cynthia L., Richardson, Paul F., Sach, Neal W., Smith, Graham L., Engstrom, Lars, Hu, Wenyue, Lam, Hieu, Lam, Justine L., Smeal, Tod, Zou, Helen Y.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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