Evolution of chalcone isomerase from a noncatalytic ancestor
Kaltenbach, Miriam, Burke, Jason R., Dindo, Mirco, Pabis, Anna, Munsberg, Fabian S., Rabin, Avigayel, Kamerlin, Shina C. L., Noel, Joseph P., Tawfik, Dan S.
Published in Nature chemical biology (01.06.2018)
Published in Nature chemical biology (01.06.2018)
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Journal Article
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P, Garcia-Barrantes, Pedro M, Camper, DeMarco, Chauder, Brian A, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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Journal Article
Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
Sun, Qi, Burke, Jason P., Phan, Jason, Burns, Michael C., Olejniczak, Edward T., Waterson, Alex G., Lee, Taekyu, Rossanese, Olivia W., Fesik, Stephen W.
Published in Angewandte Chemie International Edition (18.06.2012)
Published in Angewandte Chemie International Edition (18.06.2012)
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Strigolactone perception and deactivation by a hydrolase receptor DWARF14
Seto, Yoshiya, Yasui, Rei, Kameoka, Hiromu, Tamiru, Muluneh, Cao, Mengmeng, Terauchi, Ryohei, Sakurada, Akane, Hirano, Rena, Kisugi, Takaya, Hanada, Atsushi, Umehara, Mikihisa, Seo, Eunjoo, Akiyama, Kohki, Burke, Jason, Takeda-Kamiya, Noriko, Li, Weiqiang, Hirano, Yoshinori, Hakoshima, Toshio, Mashiguchi, Kiyoshi, Noel, Joseph P., Kyozuka, Junko, Yamaguchi, Shinjiro
Published in Nature communications (14.01.2019)
Published in Nature communications (14.01.2019)
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Journal Article
Discovery of Tricyclic Indoles That Potently Inhibit Mcl‑1 Using Fragment-Based Methods and Structure-Based Design
Burke, Jason P, Bian, Zhiguo, Shaw, Subrata, Zhao, Bin, Goodwin, Craig M, Belmar, Johannes, Browning, Carrie F, Vigil, Dominico, Friberg, Anders, Camper, DeMarco V, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
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Journal Article
Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties
Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Discovery of 6‑[(3S,4S)‑4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor
Czako, Barbara, Sun, Yuting, McAfoos, Timothy, Cross, Jason B, Leonard, Paul G, Burke, Jason P, Carroll, Christopher L, Feng, Ningping, Harris, Angela L, Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J, Mandal, Pijus, Meyers, Brooke A, Mseeh, Faika, Parker, Connor A, Yu, Simon S, Williams, Christopher C, Wu, Qi, Di Francesco, Maria Emilia, Draetta, Giulio, Heffernan, Timothy, Marszalek, Joseph. R, Kohl, Nancy E, Jones, Philip
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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High π‑Facial and exo-Selectivity for the Intramolecular Diels–Alder Cycloaddition of Dodeca-3,9,11-trien-5-one Precursors to 2-epi-Symbioimine and Related Compounds
Xiang, Ming, Wu, Yiwei, Burke, Jason P, Chruma, Jason J
Published in Journal of organic chemistry (16.09.2016)
Published in Journal of organic chemistry (16.09.2016)
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Journal Article
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme
Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R
Czako, Barbara, Marszalek, Joseph. R, Burke, Jason P, Mandal, Pijus, Leonard, Paul G, Cross, Jason B, Mseeh, Faika, Jiang, Yongying, Chang, Edward Q, Suzuki, Erika, Kovacs, Jeffrey J, Feng, Ningping, Gera, Sonal, Harris, Angela L, Liu, Zhen, Mullinax, Robert A, Pang, Jihai, Parker, Connor A, Spencer, Nakia D, Yu, Simon S, Wu, Qi, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Heffernan, Timothy P, Draetta, Giulio F, Jones, Philip
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases
Burke, Jason R, La Clair, James J, Philippe, Ryan N, Pabis, Anna, Corbella, Marina, Jez, Joseph M, Cortina, George A, Kaltenbach, Miriam, Bowman, Marianne E, Louie, Gordon V, Woods, Katherine B, Nelson, Andrew T, Tawfik, Dan S, Kamerlin, Shina C.L, Noel, Joseph P
Published in ACS catalysis (06.09.2019)
Published in ACS catalysis (06.09.2019)
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Journal Article
Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor
Kaltenbach, Miriam, Burke, Jason R., Dindo, Mirco, Pabis, Anna, Munsberg, Fabian S., Rabin, Avigayel, Kamerlin, Shina C. L., Noel, Joseph P., Tawfik, Dan S.
Published in Nature chemical biology (01.10.2018)
Published in Nature chemical biology (01.10.2018)
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Journal Article
MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific in Silico Prognostic Biomarker Validation
Yip, Shun H., Fujiwara, Naoto, Burke, Jason, Shetler, Anand, Peralta, Celina, Qian, Tongqi, Hoshida, Hiroki, Zhu, Shijia, Hoshida, Yujin
Published in Frontiers in genetics (18.09.2019)
Published in Frontiers in genetics (18.09.2019)
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Journal Article
New Fission Product Yield Measurements at Oregon State University
Tamashiro, Aaron, Burke, Jason, Padgett, Stephen, Burcher, Sean, Palmer, Todd, Palmer, Camille
Published in EPJ Web of Conferences (2020)
Published in EPJ Web of Conferences (2020)
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Conference Proceeding